What IV medications and oral medications work best to cross the blood brain barrier?
Posted by bcb1200 (Member # 25745) on :
Doxy crosses BBB. I believe Biaxin does too.
Posted by Heleneh (Member # 21207) on :
Thank you for the information. Do you know if Claforon crosses it too?
Posted by Pinelady (Member # 18524) on :
Some say tigecyclin does. I think the vote is still out.
Posted by Mariski (Member # 24942) on :
Minocycline crosses the blood brain barrier and has strong anti-inflammatory effect. In fact, minocycline is even more lipid soluble than doxycycline.
It has been discussed in other threads on this forum. For some people, it is a great ABX.
Posted by kimmie (Member # 25547) on :
I believe claforon does
Posted by Andie333 (Member # 7370) on :
I was told that ceftin does, but I don't think I ever actually double-checked.
Through a long course of ceftin, in combo with rifampin, I've been able to reverse a lot of the neuro symptoms I had and many of the physical ones, too.
Andie
Posted by lululymemom (Member # 26405) on :
Yes, I have heard that Ceftin does too..
Posted by Marnie (Member # 773) on :
Our results indicate that Borrelia spirochetes, including B. garinii, can induce the production of anti-OspE antibodies.
This implies that OspE protein is produced in vivo by B. garinii possibly enabling it to escape complement and cause a CNS infection.
PMID: 18248762
Outer surface protein E (OspE) is a complement factor H-binding virulence factor of borrelial subspecies.
It is usually absent from in vitro grown Borrelia garinii, although
***in vivo B. garinii causes neuroborreliosis (NB). ***
In conclusion, our results indicate that
all borrelial subspecies, but not necessarily all strains, causing human infections can carry ospE genes
to protect themselves against complement attack in vivo.
PMID: 20603210
Osp E MAY activate a chloride channel called CLC-2.
Which is WHY T4 drops (protective).
Remember...Frontline to protect our dogs blocks chloride channels in the ticks.
And Tamoxifen is a man-made PKC inhibitor which also happens to impact chloride channels.
Osp E binds to factor H = fH.
"Its main job is to ***regulate the Alternative Pathway of the complement system****, ensuring that the complement system is directed towards pathogens and does not damage host tissue.
Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb.
***Factor H protects self cells***
from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
Wikipedia
Ixodes scapularis salivary protein 20 (Salp20) is a member of the Ixodes scapularis anti-complement protein-like family of tick salivary proteins that
***inhibit the alternative complement pathway.***
In this study, we demonstrate that the target of Salp20 is properdin.
Properdin is a natural, positive regulator of the alternative pathway that binds to the C3 convertase, stabilizing the molecule.
Salp20 directly bound to and displaced properdin from the C3 convertase. Displacement of properdin accelerated the decay of the C3 convertase, leading to inhibition of the alternative pathway.
S20NS is distinct from known decay accelerating factors, such as decay accelerating factor, complement receptor 1, and factor H, which directly interact with either C3b or cleaved factor B.