posted
What IV medications and oral medications work best to cross the blood brain barrier?
Posts: 140 | From Illinois | Registered: Jul 2009
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bcb1200
Frequent Contributor (1K+ posts)
Member # 25745
posted
Doxy crosses BBB. I believe Biaxin does too.
-------------------- Bite date ? 2/10 symptoms began 5/10 dx'd, after 3 months numerous test and doctors
IgM Igenex +/CDC + + 23/25, 30, 31, 34, 41, 83/93
Currently on:
Currently at around 95% +/- most days. Posts: 3139 | From Massachusetts | Registered: May 2010
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posted
Thank you for the information. Do you know if Claforon crosses it too?
Posts: 140 | From Illinois | Registered: Jul 2009
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Some say tigecyclin does. I think the vote is still out.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
Minocycline crosses the blood brain barrier and has strong anti-inflammatory effect. In fact, minocycline is even more lipid soluble than doxycycline.
It has been discussed in other threads on this forum. For some people, it is a great ABX.
Posts: 40 | From New York | Registered: Mar 2010
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posted
I believe claforon does
Posts: 747 | From Utah | Registered: Apr 2010
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Andie333
Frequent Contributor (1K+ posts)
Member # 7370
posted
I was told that ceftin does, but I don't think I ever actually double-checked.
Through a long course of ceftin, in combo with rifampin, I've been able to reverse a lot of the neuro symptoms I had and many of the physical ones, too.
Andie
Posts: 2549 | From never never land | Registered: May 2005
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lululymemom
Frequent Contributor (1K+ posts)
Member # 26405
Bartonella henselae 1:100 Posts: 2027 | From British Columbia | Registered: Jun 2010
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Our results indicate that Borrelia spirochetes, including B. garinii, can induce the production of anti-OspE antibodies.
This implies that OspE protein is produced in vivo by B. garinii possibly enabling it to escape complement and cause a CNS infection.
PMID: 18248762
Outer surface protein E (OspE) is a complement factor H-binding virulence factor of borrelial subspecies.
It is usually absent from in vitro grown Borrelia garinii, although
***in vivo B. garinii causes neuroborreliosis (NB). ***
In conclusion, our results indicate that
all borrelial subspecies, but not necessarily all strains, causing human infections can carry ospE genes
to protect themselves against complement attack in vivo.
PMID: 20603210
Osp E MAY activate a chloride channel called CLC-2.
Which is WHY T4 drops (protective).
Remember...Frontline to protect our dogs blocks chloride channels in the ticks.
And Tamoxifen is a man-made PKC inhibitor which also happens to impact chloride channels.
Osp E binds to factor H = fH.
"Its main job is to ***regulate the Alternative Pathway of the complement system****, ensuring that the complement system is directed towards pathogens and does not damage host tissue.
Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb.
***Factor H protects self cells***
from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
Wikipedia
Ixodes scapularis salivary protein 20 (Salp20) is a member of the Ixodes scapularis anti-complement protein-like family of tick salivary proteins that
***inhibit the alternative complement pathway.***
In this study, we demonstrate that the target of Salp20 is properdin.
Properdin is a natural, positive regulator of the alternative pathway that binds to the C3 convertase, stabilizing the molecule.
Salp20 directly bound to and displaced properdin from the C3 convertase. Displacement of properdin accelerated the decay of the C3 convertase, leading to inhibition of the alternative pathway.
S20NS is distinct from known decay accelerating factors, such as decay accelerating factor, complement receptor 1, and factor H, which directly interact with either C3b or cleaved factor B.
Note to self...The syphilis described may not be Syph.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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nefferdun
Frequent Contributor (1K+ posts)
Member # 20157
posted
Biaxin was mentioned and it doesn't cross the BBB. Roxithromycin is another macrolide (not sold in US) and it does cross the BBB.
-------------------- old joke: idiopathic means the patient is pathological and the the doctor is an idiot Posts: 4676 | From western Montana | Registered: Apr 2009
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