I know the CD57 isn't the end all be all of lyme tests. but I know that its a good diagnosis marker if its really low
My question is, is a low CD57 a result of LATE stage lyme or just lyme infection in general? Would someone with early disseminated lyme test very low on the CD57?? I've read it takes time for the CD57 to get very low. So is it only connected with late stage lyme (infection of at least one year?) or just lyme infection in general regardless of the stage?
[ 01-17-2011, 10:50 AM: Message edited by: lymegal23 ]
Posted by lymegal23 (Member # 28573) on :
up Posted by Dninty9 (Member # 23934) on :
I am also very interested in knowing this ....
Posted by lymegal23 (Member # 28573) on :
I'm interested too....hopefully someone comes along and enlightens us about this Posted by x9w5a34 (Member # 28204) on :
I know that I got infected only in the last few days of June 2010 but my CD57 was in the teens when I tested in late September. So I don't think there's any correlation between the stage of Lyme and the CD57 numbers. Of course, that's just my opinion and I could be wrong!
Posted by Lymeorsomething (Member # 16359) on :
I don't know, but I do feel that the CD-57 is a good marker for lyme when lyme is the body's major issue.
I know for me the CD-57 has been consistently low and not fluctuating wildly.
Posted by jeffinca11 (Member # 25584) on :
Hi guys. Here's some information re: cd-57 from the 2010 Ilads conference.
"CD57 suppression may occur in XMRV as well as in Borrelia.
(Editor's Note: There was also talk at this event of Chlamydia
pneumoniae causing CD57 depression as well as a discussion of
CD57 going down when one is in the midst of a Herxheimer or
die-off reaction. Thus, it seems that CD57 may not be as
specific for Borrelia as may have been previously believed. That
said, I do still believe it is an important marker to help provide
additional insight as to whether or not someone may have Lyme
disease and when they may be able to stop antibiotic therapy
with a lower possibility of relapse.)"
Dr. Ray Stricker shared the following on the topic of testing:
Band 39 is the most specific for Borrelia
IgM Western Blot has more possibility of a false positive result than the IgG Western Blot
CD57 may be affected by Borrelia, Chlamydia pneumoniae, and Tuberculosis
CD57 will generally go down within 3 months of infection
According to Dr. Stricker, the test is valid for children (though responses may be exaggerated) though Dr. Jones shared that he did not find it to be very helpful with children
CD57 may go down with Herxheimer reactions. Inflammation may result in a drop in CD57
Elevated CD57 such as 400 may occur. HIV patients do exist with high CD4 counts as a corollary though the CD4 cells may not work well or function properly. Thus, CD57 can tell us the quantity of the cells but the issue may be the quality or whether or not the cells can function optimally.
(Another practitioner suggested that many cases of high CD57 show drops in CD57 results once treatment begins)
Stem cell therapy is not known to affect CD57 counts though another practitioner commented that she had seen an initial drop in CD57 after stem cell therapy with continued ongoing increases as time passed after stem cell therapy
C4a is an inflammation marker. It generally correlates with symptom presentation
C3a is an autoimmune marker
C4a can be due to infection
Posted by lymegal23 (Member # 28573) on :
I thought I read somewhere tho that if a persons CD-57 is very low. like in 20 or below, that usually means theyve had lyme for at least a year? This is the websit I read it at..
I guess what I want to know here is, does a REALLY low cd-57 ( 20 or below) mean that the lyme load is very high in the person. if they get the cd-57 taken BEFORE they start treatment? I'd assume if its that low it means they have a high bacteria load
anyone know any info on this?
Posted by annier1071 (Member # 28977) on :
I have the same confusion. I have lyme and my most recent bit was may 2009 but wasnt diagnosed till dec 2010..symtoms became bad in june 2010 exactuly one year later.Yet my cd 57 was 175 or normal? I really do not know what it is suppose to tell.
Posted by lymegal23 (Member # 28573) on :
do you have co-infections?
Posted by annier1071 (Member # 28977) on :
I was negative for coinfections
Posted by lymednva (Member # 9098) on :
Coinfections should be treated using clinical diagnosis, as testing is not very reliable. If you are symptomatic, your LLMD should be treating you for them.
Posted by jwall (Member # 22999) on :
I became sick 2 years ago and when my CD-57 was tested back in June, it was 24. So, 1.5 years after I became sick, it was low. I hadn't started treatment at that point. Not sure if it means I have a high bacteria load or not. I believe that is what the C4a is for...to see how toxic one is from infection. A really high c4a would indicate a lot of toxins from infection. I'm not sure on that though! I know my LLMD put me on deplin and methyl B-12 injections to help detox b/c of the high c4a #.
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