I want to try this. I've been on small doses of FolaPro and I'm doing well.
Some patients report immediate and dramatic improvements in fatigue and depression when they start Deplin.
I could use some of that.
Others' experiences?
Posted by faithful777 (Member # 22872) on :
My husband and I tested positive for the MTHFR allele and both take Deplin and do B12 injections.
I wouldn't say the there is any dramatic improvement in stamina (just some) but it did help the depression. We both are a little clearer with our brain fog.
Posted by Lala (Member # 29864) on :
I took 5-MTHF from Thorne, which is prescription free. It had some positive effect on depression, but I got some side effects on these higher doses- flu like symptoms and headache. So I went down to smaller dose.
Posted by lymeladyinNY (Member # 10235) on :
I take it with B-12 shots but I don't notice the effects because I take so many other pills. All I know is I feel better overall with anti-seizure meds and IV antibiotics thanks to my new LLMD.
Posted by LaniMo (Member # 37384) on :
Deplin hasn't helped my depression, but I like the fact that it is a natural substance and doesn't seem to cause me any side effects.
Of course, insurance doesn't cover it.
Good luck!
Posted by racer (Member # 30438) on :
I was prescribed it from my doctor for depression - but it was too expensive since insurance didn't cover it. Around $150 I think. Too bad!
Posted by BoxerMom (Member # 25251) on :
Thanks everyone. I'm going to try the Thorne 5-MTHF.
Yesterday, as an experiment, I took a ridiculous amount of Folapro. I had much more energy and much less depression than usual. Maybe a good sign.
I woke today with the worst headache ever. Maybe not a good sign.
Grrrr....
I'll post my results with the Thorne product.
Posted by faithful777 (Member # 22872) on :
My insurance covers Deplin with a copay.
Posted by Marnie (Member # 773) on :
Deplin is MUCH stronger than FoloPro.
If FoloPro is working/helping...why switch?
Note if you have the MTHFR gene type, you absolutely need to take a daily baby aspirin.
You are at greater RISK for clotting problems.
The brain issue is because inflammation (brain)impacts "innocent bystanders" = **SY cells** in the brain - knocks them off. I linked it at the bottom of my post about atherosclerosis.
The inflammation that happens during lyme is throughout the system...everywhere.
For brain inflammation, OmegaBrite may help. Sorry it is expensive and is only available over the internet.
It is a very unusual formulation of the Omega 3 fatty acids (our brain needs glucose AND fatty acids...which is why infant formulas are loaded with DHA).
EPA is "anti-inflammatory". It is the FUNCTIONAL omega 3. DHA is STRUCTURAL.
Stoll...Harvard...believes we need a LOT more EPA than DNA.
P.S. Something like 1 in 20 people are effected by the MTHFR gene problem and are at greater risk for depression, and other problems. Our genes do NOT have to determine our destiny. There ARE work-arounds IF we know we inherited a genetic problem.
Posted by faithful777 (Member # 22872) on :
There are other ways to thin the blood other than the baby aspirin. I can't tolerate any NSAIDS at all.
I do use nattozymes and viatalzyme to thin the blood out. I also take 4.5 grams of good quality fish oil daily.
Both my husband and I have the MTHFR heterogeous gene.
Posted by nefferdun (Member # 20157) on :
Everything depends on ALL your mutations, not just MTHFR. You are only at risk of clotting if you have C677T. The other mutations affect what you can take. I am not supposed to have aspirin (can't remember why) so I take lumbrokinase or boluoke.
I am supposed to get BH4 today to reduce ammonia. That should be interesting.
Hydroxy B12 increased my energy a lot.. I also take carnitine and CoQ10 for energy and have NADH but have not started it yet.
Posted by Marnie (Member # 773) on :
Not being able to process folic acid to its useful form impacts another enzyme
which is called BH4.
BH4 is an enzyme that is used to make serotonin, dopamine, thyroid hormones, melanin and to
detox ammonia.
It is recharged by *folate*/= folic acid ... and/or niacin ... and/or vitamin C.
With certain combinations of the MTHFR gene, some people have a limited supply of BH4.
Those people can probably be identified as those who have tendencies towards depression,
low energy,
all-or-nothing focus,
hypothyroid (even subclinical),
are pale,
and may have elevated blood ammonia.
These people will do best on small amounts of very high quality protein, and lots (?) of methyl folate.
Reasons to Suspect MTHFR gene problem:
If you have low dopamine AND low serotonin AND low thyroid function (even subclinical). If you have high blood ammonia. If you have MTHFR polymorphisms.
Posted by WPinVA (Member # 33581) on :
Deplin was one of the first things I went on last summer when I was very, very sick and I'm still taking it. I can't say if it helped or not though. I did start to get better very slowly during that time, but that also could have been the doxy.
My insurance does cover it. After reading others' posts, I guess I'm lucky on that point.