Lipid Exchange between Borrelia burgdorferi and Host Cells. http://www.ncbi.nlm.nih.gov/pubmed/23326230 LoS Pathog. 2013 Jan;9(1):e1003109. doi: 10.1371/journal.ppat.1003109. Epub 2013 Jan 10.
Crowley JT, Toledo AM, Larocca TJ, Coleman JL, London E, Benach JL. Source
Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America. Abstract
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness,
are antigenic,
and could be important in mediating interactions with cells of the eukaryotic host.
We show that the spirochetes can acquire cholesterol from plasma membranes of epithelial cells.
In addition, through fluorescent and confocal microscopy combined with biochemical approaches,
we demonstrated that B. burgdorferi labeled with the fluorescent cholesterol analog BODIPY-cholesterol or
(3)H-labeled cholesterol
transfer both cholesterol and cholesterol-glycolipids
to HeLa cells.
The transfer occurs through two different mechanisms,
by direct contact between the bacteria
and eukaryotic cell
and/or through release of outer membrane vesicles.
Thus, two-way lipid exchange between spirochetes and host cells can occur.
This lipid exchange could be an important process that contributes to the pathogenesis of Lyme disease. ----------- Whooo HOooo!!!
Posted by Pinelady (Member # 18524) on :
We needed this research on many fronts. Ya know all those cholesterol plagues and calcium deposits in arteries they never alluded to a cause other than you's just fat....Nope.
All those tiny calcium deposits that herald most breast cancers? Yep.
Infected cell lines used in vaccine made with HeLa cells contaminated with spirochetes? Yep.
Ghost cells associated with prion protein infections. Yep.
Posted by VV (Member # 38828) on :
Not quite sure I understand. Is this helpful in devising a new treatment?
Posted by seibertneurolyme (Member # 6416) on :
I interpret this differently than Pinelady.
I think it means that borrelia needs cholesterol and robs it from the body.
Babesia has been proven to rob the good fats -- phosphatidylcholine -- and I wouldn't be surprised if borrelia does not do the same. Don't have time to look up that pubmed article right now.
That is one of the reasons for nerve damage -- one of the main components of the myelin sheath is phosphatidylcholine I think.
Bea Seibert
Posted by Pinelady (Member # 18524) on :
The transfer occurs through two different mechanisms,
by direct contact between the bacteria
and eukaryotic cell
and/or through release of outer membrane vesicles. -------------------------- Bea---it means that the vaccines that used HeLa cells from a woman who had Syphilis were most likely infective. That makes them responsible.
It means they continue to screw up big time because of the genetic variance seen in borreli/hiv is not the only place it has infected. It means vaccines are done.
Posted by VV (Member # 38828) on :
"It means vaccines are done."
I still don't understand.
Posted by nefferdun (Member # 20157) on :
I have trouble following scientific explanations but PR multiplies 100 times faster with fats. So borellia likes fats too?
I have been staying off drugs using liposomal phosphatidylcholine with EDTA to degrade the biofilm.
Posted by VV (Member # 38828) on :
I take 2 tablespoons of soy lecithin a day. Does that fit in here somewhere?
Posted by Pinelady (Member # 18524) on :
I would Plant sourced vitamin E instead of GM soy.
Vitamin E can reduce cholesterol.
But you don't want to reduce cholesterol unless your killing bugs.
Posted by Pinelady (Member # 18524) on :
HeLa cells came from a woman who had spirochetal disease.
Henrietta Lacks immortal cells used in vaccines came from a woman who had Syphilis.
They were infective not protective. That is why they were immortal.
That is where the real cause of AIDS came from. Not HIV.