LymeNet Flash: IgM positive and IgG negative opinions?

This is topic IgM positive and IgG negative opinions? in forum Medical Questions at LymeNet Flash.

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Posted by elara (Member # 41819) on :

I'd like opinion on an Igenex test result? Plus I'd be curious how many others have seen this in chronic long term illness rather than a new infection?

Western Blot IgM CDC and IGgenex positive

18 kDa +
23-25 kDa +++
31 kDa IND
39 kDA IND
41 kDa +
83 kDa IND

Western Blot IgG

39 kDa IND
41 kDa +

Multiplex PCR negative

IFA Bb negative

Seems od the IgM would be so positive in a late infection with no positive IgG's except the Flagellen 41

Could this be an EBV cross reaction?

Repeat opinions?

thanks

Posted by Keebler (Member # 12673) on :

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With lyme, IgM and IgG is often sort of "flipped" from what one might expect in other infections.

IgM is usually a big flag for persistent / chronic (and therefore very much active) in lyme. But any positive band, either IgM or IgG is an important flag. See the Western Blot article here, explaining it:

http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=2;t=015508;p=0

Diagnosing Lyme Disease (&/or whatever else is going on)

http://www.anapsid.org/lyme/lymeseroneg.html

Reasons for False Negative (Seronegative) Test Results in Lyme Disease
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[ 02-19-2015, 10:40 PM: Message edited by: Keebler ]

Posted by Lymetoo (Member # 743) on :

Either way, IgG or IgM .. it needs to be treated.

Dr C of MO says if either one is positive, it is positive and needs to be treated.