Note that they used patients who still have symptoms after treatment. (Known by most of us as "Chronic Lyme disease" but by the CDC and a lot of the scientific community as" Post Treatment Lyme disease".
From the study: Summary
Lyme disease (LD) is tick-borne disease whose post-treatment sequelae are not well understood.
For this study, we enrolled 152 individuals with symptoms of post-treatment LD (PTLD) to profile their peripheral blood mononuclear cells (PBMCs) with RNA sequencing (RNA-seq).
Combined with RNA-seq data from 72 individuals with acute LD and 44 uninfected controls, we investigated differences in differential gene expression.
We observe that most individuals with PTLD have an inflammatory signature that is distinguished from the acute LD group.
By distilling gene sets from this study with gene sets from other sources, we identify a subset of genes that are highly expressed in the cohorts
but are not already established as biomarkers for inflammatory response or other viral or bacterial infections.
We further reduce this gene set by feature importance to
establish an mRNA biomarker set
capable of distinguishing healthy individuals
from those with acute LD or PTLD as a candidate for translation into an LD diagnosis.
Posted by aklnwlf (Member # 5960) on :
Good news!
Posted by map1131 (Member # 2022) on :
I wrote down all 35 of these genes found in chronic Lyme study. I went to my 23&me raw data (2014) and one by one I entered the specific genes search.
Out of the 35 I am +/+ for 28 of them. Whether these mutations can be turned off and on during the remission or flare-ups is another question. So many questions??????
Pam
Posted by Bartenderbonnie (Member # 49177) on :