Note that they used patients who still have symptoms after treatment. (Known by most of us as "Chronic Lyme disease" but by the CDC and a lot of the scientific community as" Post Treatment Lyme disease".
From the study: Summary
Lyme disease (LD) is tick-borne disease whose post-treatment sequelae are not well understood.
For this study, we enrolled 152 individuals with symptoms of post-treatment LD (PTLD) to profile their peripheral blood mononuclear cells (PBMCs) with RNA sequencing (RNA-seq).
Combined with RNA-seq data from 72 individuals with acute LD and 44 uninfected controls, we investigated differences in differential gene expression.
We observe that most individuals with PTLD have an inflammatory signature that is distinguished from the acute LD group.
By distilling gene sets from this study with gene sets from other sources, we identify a subset of genes that are highly expressed in the cohorts
but are not already established as biomarkers for inflammatory response or other viral or bacterial infections.
We further reduce this gene set by feature importance to
establish an mRNA biomarker set
capable of distinguishing healthy individuals
from those with acute LD or PTLD as a candidate for translation into an LD diagnosis.
-------------------- Ann-OH Posts: 1584 | From Ohio | Registered: Aug 2014
| IP: Logged |
aklnwlf
Frequent Contributor (5K+ posts)
Member # 5960
posted
Good news!
-------------------- Do not take this as medical advice. This comment is based on opinion and personal experience only.
Alaska Lone Wolf Posts: 6137 | From Columbus, GA | Registered: Jul 2004
| IP: Logged |
map1131
Frequent Contributor (5K+ posts)
Member # 2022
posted
I wrote down all 35 of these genes found in chronic Lyme study. I went to my 23&me raw data (2014) and one by one I entered the specific genes search.
Out of the 35 I am +/+ for 28 of them. Whether these mutations can be turned off and on during the remission or flare-ups is another question. So many questions??????
Pam
-------------------- "Never, never, never, never, never give up" Winston Churchill Posts: 6478 | From Louisville, Ky | Registered: Jan 2002
| IP: Logged |
Bartenderbonnie
Frequent Contributor (1K+ posts)
Member # 49177
posted
That’s genius Pam!!!
Who can you ask to get answers to your questions?
Posts: 2977 | From Florida | Registered: Nov 2016
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic