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» LymeNet Flash » Questions and Discussion » Medical Questions » Another AD trigger (besides DDT and Bb)

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Author Topic: Another AD trigger (besides DDT and Bb)
Marnie
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β-methylamino-L-alanine (BMAA), an *amino acid*

produced by

cyanobacteria (blue-green algae), has been linked to

neurodegenerative disease in indigenous communities in Australia and the South Pacific (Guam) and more recently to sporadic Amyotrophic Lateral Sclerosis (sALS) and

Alzheimer’s disease (AD) in Canada and the USA.

Cyanobacteria are ubiquitously distributed in terrestrial, fresh water and marine environments and

due, in some cases, to mismanagement of these resources

human exposure to BMAA is increasing.

Of great concern is recent data showing BMAA is

***bioconcentrated by aquatic species***

raising the possibility that we could be subject to ‘silent’ exposure to BMAA

in the absence of any readily identifiable cyanobacterial blooms.

https://www.uts.edu.au/sites/default/files/chemistry%20honours%20projects%202014.pdf

I'll have a steak please...no, wait...DDT was sprayed garden/field adjacent to where the
cattle do roam...?

Wanna talk about *alanine* and its relationship to Bb?

Bb’s 16s (r) RNA = 16S rRNA- *alanine* transfer RNA (tRNA ala).

“It has been suggested that ***bb0666 ***encodes a putative N-acetylmuramyl-L-***alanine*** amidase involved in peptidogylcan synthesis critical for cell division.”

http://jid.oxfordjournals.org/content/200/8/1331.full

Why does that number not surprise me? Does the berberine metabolite mess with Bb's 16s (r)RNA?

Ribosomal *(r)* RNA genes are
likely to be critical for survival and persistence in its hosts.


It appears berberine is metabolized to berberrubine which interacts with HP14, a

substrate of RNA

involved in RNA folding. (Linked previously).

P.S. Viruses such as HIV have RNA genomes that can be converted into DNA by an enzyme by an enzyme called reverse transcriptase.

Posts: 9424 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
Razzle
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So this means that the RNA that can be converted into DNA may ultimately become incorporated into a cell as part if it's DNA? Is this how Viruses "hijack" cells to reproduce?

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

Posts: 4166 | From WA | Registered: Feb 2011  |  IP: Logged | Report this post to a Moderator
   

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