posted
Does anyone know why the package insert for deplin says do not use if you have the MTHFR mutation? I've also read not to take methyl B-12 injections with this mutation.
Any ideas why? My Dr. has prescribed both to help with detox. I have a hard time taking Deplin - it causes increased anxiety and brain fog. Methyl B-12 seems to be helping me.
Thanks!
Posts: 618 | From NC | Registered: Oct 2009
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"DEPLIN� is indicated regardless of MTHFR C677T polymorphism genotype."
To clarify, if you have the MTHFR polymorphism, you have increased need for folate, so it should be the exact opposite.
I think that if you are deficient in Folate, Methyl-B12 can make you tired and vice versa. At least that's my experience.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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posted
That's what I thought about deplin and the MTHFR mutation - that it would actually be helpful. However, this is what my prescription pamphlet says. It left me confused...
DuLeek Tablets are orally administered prescription vitamin/medical food indicated for the supplemental requirements of patients with nutritional deficiencies or are in need of dietary supplementation.
Our product, Duleek-Dp 7.5 and 15, is not indicated to cure or mitigate a disease. It is an advanced strength of Vitamin B9, or folate that is prescribed under the care or supervision of a physician. We do not promote off label use or condone a use that is outside the instructions of the managing physician. Specifically, patients should not be prescribed Duleek-Dp 7.5 and 15 for MTHFR mutation related conditions.
Do not take this product if you are at risk due to MTHFR mutation, or - specifically, are at risk due to Thermolabile MethyleneTetraHydroFolate Reductase (MTHFR), or C677T/MTHFR, mutation. Patients at risk for C1298T/MTHFR should also not take this product.
Posts: 618 | From NC | Registered: Oct 2009
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posted
Hmmmm. It appears that you got DuLeek DP, which they thought was a generic for Deplin.
Pamlab(The maker of Deplin) says that Duleek contains folic acid instead of 5MTHF. You might want to talk to your pharmacist and get your prescription changed. So the warning makes sense, because people with MTHFR won't be able to metabolize duleek at all.
PS: Wow, you actually read your package inserts. Congratulations you caught this problem.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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posted
Thanks! I DO read all my inserts - I know, I have an anxiety disorder! It is a direct result of almost 2 years of misdiagnosis and tons of prescription meds thrown at me that did not work or caused even more problems. I started to not trust doctors or pharmaceutical companies and started researching everything! I learned not to trust doctors and blindly take a medication without reading about it first!
I am confused by all of the above b/c it seems one who needs folic acid, esp. those with the MTHFR gene, would benefit from this. It actually causes anxiety and brain fog in me, so I haven't been taking it. My LLMD said to cut the dose in half and try that. I need to run this by him next time and get his thoughts.
I have also read the same thing about the methyl B-12 shot which I've been taking weekly??
Posts: 618 | From NC | Registered: Oct 2009
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posted
Oh...I just read your link above. So, duleek is not generic for deplin which I assumed it was. They are different products! How did you catch that?
I will print this out and give to my pharmacist and to my LLMD. I did not have good results with duleek.
Posts: 618 | From NC | Registered: Oct 2009
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karenl
Frequent Contributor (1K+ posts)
Member # 17753
posted
You need to take the Hydroxy B12.It helps so much. Pm if you need a pharmacy, it is 65 per month.
But my doctor also prescribed the Deplin 7.5 but they gave me the Duleek. If I understand the post right I need to go to my pharmacy and give the Duleek back and get me the Deplin. Jwall thanks for your good work and posting it for us. Karen
Posts: 1834 | From US | Registered: Oct 2008
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
If you have MTHFR, you can't process regular forms of folate. Google Amy Yasko for more info, including the folate metabolic cycle.
(Some folks may take L-5-Methyl Tetrahydrofolate to circumvent folate-related mutation issues.)
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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quote:Originally posted by karenl: But my doctor also prescribed the Deplin 7.5 but they gave me the Duleek. If I understand the post right I need to go to my pharmacy and give the Duleek back and get me the Deplin.
You should print this out and take it your pharmacist. Duleek is not a generic for Deplin.
karenl
Frequent Contributor (1K+ posts)
Member # 17753
posted
I get my Deplin. The pharmacy now has it already on the computer that they are not allowed to substitute Deplin.
Posts: 1834 | From US | Registered: Oct 2008
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posted
Sorry, my slow brain cannot quite understand. So, duleek is a different form of folic acid and is the kind that those w/the MTHFR mutation cannot metabolize? but, Deplin is the form of folic acid that would be helpful for MTHFR people?? Is that right? So, I can try Deplin instead. I wonder if this is why my anxiety and brain fog were so bad w/duleek.
Thanks ninjaphire for finding this!!! It is very important to know! I think we should start a 'duleek is not the same as deplin' thread. I will let my pharmacy know as well as my lyme Dr. that he should probably "check" the do not substitute with generic box.
Posts: 618 | From NC | Registered: Oct 2009
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quote:Originally posted by jwall: So, duleek is a different form of folic acid and is the kind that those w/the MTHFR mutation cannot metabolize? but, Deplin is the form of folic acid that would be helpful for MTHFR people?? Is that right? So, I can try Deplin instead. I wonder if this is why my anxiety and brain fog were so bad w/duleek.
Folic acid needs to be converted to L-Methylfolate which is the active form. Some people have trouble doing this, because they have the MTHFR polymorphism.
Deplin is L-Methylfolate, which needs no conversion. duleek is folic acid, which needs to be converted, so it's not as effective, if it works at all. The nasty part is that they advertised it as a generic for deplin, which is a lie.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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It is a direct result of almost 2 years of misdiagnosis and tons of prescription meds thrown at me that did not work or caused even more problems. I started to not trust doctors or pharmaceutical companies and started researching everything! I learned not to trust doctors and blindly take a medication without reading about it first! ![[Smile]](smile.gif)
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