this link refers to celery and green peppers wonder how much you'd have to eat!!!!
then there is turmeric...etc
wonder if any of this makes a squat of a difference.
Posts: 11 | From NYC | Registered: Apr 2011
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
I'm surprised they recommend the green peppers, because I was under the impression that nightshade family foods can actually promote inflammation for some people, and green peppers are a nightshade family food (along with potatoes, chile peppers, eggplant, and tomatoes).
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4167 | From WA | Registered: Feb 2011
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posted
I have used the one from Dr. S's book, The Lyme Solution, and found it to be VERY helpful... night and day difference in my pain. I stay away from nightshades for sure...
Posts: 859 | From Southeast | Registered: Mar 2011
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
I'm w/Razzle about the nightshade business. That's my understanding as well.
I think LongVida Circumin- and yeppers, I've tried other brands- is an awesome product. I've been on it for about a year now.
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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posted
My doc gave me the following anti-oxidant regimen to fight inflammation:
1) Vitamin B12 a) Numerous options: methylcobalamin, hydroxocobalamin, cyanoc1) Vitamin B12 a) Numerous options: methylcobalamin, hydroxocobalamin, cyanocobalamin. Sublingual or injectable administration may be superior to oral (potential for unpredictable absorption when taken orally). The dose can vary widely and range from 1000 micrograms (1 mg) up to several thousand micrograms. The frequency can vary from daily to monthly (the less frequent dosing is usually with injections). Some experts prefer the methyl or hydroxyl form. The injectable forms can be given subcutaneous or intramuscular and require a prescription. b) Cobalamin acts as a methyl donor. It is very important for the proper function of the methylation cycle, the methionine synthase enzyme and to allow for adequate methylation reactions.
2) Folate a) The best options are either methylfolate or folinic acid (as opposed to regular folic acid which is found in most multiple vitamins). There are several methylfolate supplements (Metafolin, Folapro, Deplin, Cerefolin, among others) of which the doses can vary from 800 micrograms (0.8 mg) to 15 mg. Folinic acid can be given as 0.8 mg ranging up to 25 mg or higher (the high dose prescription form is leucovorin). Note that all doses of folate greater than 1000 micrograms (1 mg) require a prescription. b) Folate also acts as a methyl donor (in conjunction with B12) and is very important in the methylation cycle. Genetic defects of folate metabolism, which impair the normal methyl donor reaction, are quite common in the general population. Proper folate supplementation is very important in individuals with these genetic abnormalities.
3) Glisodin (SOD) a) This is a superoxide dismutase (SOD) enzyme derived from melon which is coupled to gliadin (wheat protein). The gliadin coupling allows the SOD to be readily absorbed when given orally. Otherwise SOD is inactivated in the digestive environment of the stomach. Glisodin may not be tolerated in gluten / gliadin sensitive individuals (however, it is a very small amount compared to the amount of gliadin in an ordinary diet). b) Glisodin increases the activity of not only SOD but also glutathione peroxidase and catalase (actually �turns on� the genes for the production of these enzymes). These three enzymes represent the most potent antioxidant (free radical inactivation) systems in the body. These enzymes do not need to be recycled and can rapidly inactivate billions of free radicals that are generated. c) Suggested dose: 500 � 1000 mg per day (1 mg = 1 IU). There are several brands of SOD that contain Glisodin (examples SuperGlisodin, Source Naturals Glisodin).
4) Sulforaphane a) Sulforaphane is derived from glucoraphanin which is found in high concentrations in broccoli sprouts. It is produced when an enzyme (myrosinase) converts the glucoraphinin to the active form, sulforaphane. Intestinal bacteria produce myrosinase, thus the broccoli derivatives can be converted to the active form in the gut. b) Sulforaphane is a potent inducer (signaling molecule) of the nrf2 transcription factor which turns on synthesis of a variety or important antioxidant enzymes, including enzymes that lead to the synthesis of GSH. Thus, it naturally �turns on� GSH production. It also increases the activity of Phase II detoxification enzymes. Sulforapahne acts as an anti-inflammatory, antioxidant, anticancer agent and potent detoxifier amongst other properties. c) It is usually sold as a broccoli sprout product. Examples are Vitalica and Broccoli Sprout Capsules by Handy Pantry (dose is one or two daily for both).
5) Trimethylglycine (TMG) a) TMG, also called betaine, is derived from sugar beets. The usual dose is 1000 mg twice a day (the dose used in the studies by James et al in autism patients). b) It is a methyl donor but works independently from the B12 / folate pathway. TMG can activate the methylation pathway and improve methylation status. It is primarily active in the liver. c) Remember, anything that improves methylation (B12, folate, TMG) can also increase the production of GSH (via the transsulfuration pathway).
6) Cysteine a) GSH is made up of three amino acids (glutamic acid, glycine and cysteine). The rate limiting amino acid and therefore, the essential amino acid for synthesis and function of GSH is cysteine. GSH has numerous important functions: antioxidant, free radical scavenging, regulates DNA and mitochondrial function, detoxification of numerous toxins such that they can be excreted from the body, etc. It is an essential factor for the function of almost all cells. GSH has antiviral effects for several different viruses including HIV and murine retroviruses. GSH has been called the �master antioxidant.� The major producer of GSH is the liver but it can be synthesized in several organs. b) Cysteine administration can increase the synthesis of GSH by providing the key precursor (especially in the setting of cysteine / GSH deficiency). c) There are several ways to administer cysteine. These include N-acetyl-cysteine (NAC), whey protein and actual GSH. NAC is given orally, is well absorbed and is converted to cysteine in the body. The doses vary widely ranging from 150 mg to several thousand milligrams per day (a common dose is 600 mg twice a day). Many brands of whey protein are available. There is evidence that �lightly denatured whey protein� (which has undergone a specific filtration process and has not been overheated) is more biologically active and has markedly improved protein content in a usable form that can raise GSH levels. Some popular brands are ImmunoPro (5 grams per scoop) and Immunocal (10 grams per pouch). These whey protein concentrates also contain lactoferrin which has been shown to have antiviral properties (including HIV). The actual GSH molecule is not well absorbed via oral administration (although there is a lipid coated preparation that considerably improves absorption). It can be given IV as well as several other routes of administration. Either whey protein or NAC have probably been the easiest, least expensive and most popular methods for increasing cysteine intake.
7) Vitamin C a) Lipo-Spheric Vitamin C (1000 mg per packet). Suggest 1 � 4 packets per day. b) This new formulation entails vitamin C which is covered with a lipid coating that allows for excellent absorption from the GI tract (98% absorbed). Blood levels and tissue levels are greatly enhanced, thus the results are similar to IV vitamin C but there are less GI side effects than conventional forms of oral vitamin C. c) Vitamin C has numerous properties that may be effective in this setting: it is an antioxidant, helps recycle GSH, etc. One of the most important properties is the ability to stabilize and recycle BH4 (tetrahydrobiopterin). BH4 is a critical cofactor for the functioning of the nitric oxide synthase enzymes. If BH4 levels are low, the enzyme becomes �uncoupled� and instead of synthesizing nitric oxide it switches over and produces superoxide (a very powerful free radical). The superoxide that is produced (by reacting with nitric oxide) forms peroxynitrite which results in BH4 degradation and inactivation, thus a vicious cycle is initiated. By restoring BH4 levels, ascorbic acid can break the cycle and diminish oxidative stress. Low BH4 may be a major player in oxidative stress and ascorbic acid can restore these levels to normal.
8) Other (miscellaneous) a) Various other supplements may be helpful. Several are important cofactors for enzymes in the methylation pathway, formation of glutathione or both. These include selenium, zinc, magnesium and vitamin B6. b) Antioxidants: various supplements that scavenge free radicals, reduce oxidative stress and reduce oxidized glutathione back the reduced form of glutathione. Examples are alpha lipoic acid, vitamin C, vitamin E, and numerous plant based polyphenols. c) Other substances may directly inhibit retroviruses. One example is curcumin (such as Meriva SR). d) Omega 3 fatty acids e) Vitamin D f) Probiotics: help maintain a healthy GI tract
Basic Supplement Protocol for XMRV-associated methylation abnormalaties , glutathione depletion and oxidative stress
1) Vitamin B12 injections 1cc (1000 micrograms) weekly or sublingual methyl B12: 5000 micrograms per day. 2) Folinic acid 800 micrograms: two � three per day or Metafolin (methylfolate) at same dose. These two can also be combined. 3) Glisodin (SuperGlisodin): 250 mg � 500 mg twice daily 4) Broccoli sprout (Vitalica): one or two capsules daily 5) TMG: 1000 mg twice daily 6) Biologically active whey protein: ImmunoPro one to four scoops per day or Immunocal one to two pouches per day. An alternative to whey protein is NAC 600 mg: two to four per day. 7) Lipo-Spherical Vitamin C: 1 � 4 packets per day
(All of these can be obtained from various Internet sites)
obalamin. Sublingual or injectable administration may be superior to oral (potential for unpredictable absorption when taken orally). The dose can vary widely and range from 1000 micrograms (1 mg) up to several thousand micrograms. The frequency can vary from daily to monthly (the less frequent dosing is usually with injections). Some experts prefer the methyl or hydroxyl form. The injectable forms can be given subcutaneous or intramuscular and require a prescription. b) Cobalamin acts as a methyl donor. It is very important for the proper function of the methylation cycle, the methionine synthase enzyme and to allow for adequate methylation reactions.
2) Folate a) The best options are either methylfolate or folinic acid (as opposed to regular folic acid which is found in most multiple vitamins). There are several methylfolate supplements (Metafolin, Folapro, Deplin, Cerefolin, among others) of which the doses can vary from 800 micrograms (0.8 mg) to 15 mg. Folinic acid can be given as 0.8 mg ranging up to 25 mg or higher (the high dose prescription form is leucovorin). Note that all doses of folate greater than 1000 micrograms (1 mg) require a prescription. b) Folate also acts as a methyl donor (in conjunction with B12) and is very important in the methylation cycle. Genetic defects of folate metabolism, which impair the normal methyl donor reaction, are quite common in the general population. Proper folate supplementation is very important in individuals with these genetic abnormalities.
3) Glisodin (SOD) a) This is a superoxide dismutase (SOD) enzyme derived from melon which is coupled to gliadin (wheat protein). The gliadin coupling allows the SOD to be readily absorbed when given orally. Otherwise SOD is inactivated in the digestive environment of the stomach. Glisodin may not be tolerated in gluten / gliadin sensitive individuals (however, it is a very small amount compared to the amount of gliadin in an ordinary diet). b) Glisodin increases the activity of not only SOD but also glutathione peroxidase and catalase (actually �turns on� the genes for the production of these enzymes). These three enzymes represent the most potent antioxidant (free radical inactivation) systems in the body. These enzymes do not need to be recycled and can rapidly inactivate billions of free radicals that are generated. c) Suggested dose: 500 � 1000 mg per day (1 mg = 1 IU). There are several brands of SOD that contain Glisodin (examples SuperGlisodin, Source Naturals Glisodin).
4) Sulforaphane a) Sulforaphane is derived from glucoraphanin which is found in high concentrations in broccoli sprouts. It is produced when an enzyme (myrosinase) converts the glucoraphinin to the active form, sulforaphane. Intestinal bacteria produce myrosinase, thus the broccoli derivatives can be converted to the active form in the gut. b) Sulforaphane is a potent inducer (signaling molecule) of the nrf2 transcription factor which turns on synthesis of a variety or important antioxidant enzymes, including enzymes that lead to the synthesis of GSH. Thus, it naturally �turns on� GSH production. It also increases the activity of Phase II detoxification enzymes. Sulforapahne acts as an anti-inflammatory, antioxidant, anticancer agent and potent detoxifier amongst other properties. c) It is usually sold as a broccoli sprout product. Examples are Vitalica and Broccoli Sprout Capsules by Handy Pantry (dose is one or two daily for both).
5) Trimethylglycine (TMG) a) TMG, also called betaine, is derived from sugar beets. The usual dose is 1000 mg twice a day (the dose used in the studies by James et al in autism patients). b) It is a methyl donor but works independently from the B12 / folate pathway. TMG can activate the methylation pathway and improve methylation status. It is primarily active in the liver. c) Remember, anything that improves methylation (B12, folate, TMG) can also increase the production of GSH (via the transsulfuration pathway).
6) Cysteine a) GSH is made up of three amino acids (glutamic acid, glycine and cysteine). The rate limiting amino acid and therefore, the essential amino acid for synthesis and function of GSH is cysteine. GSH has numerous important functions: antioxidant, free radical scavenging, regulates DNA and mitochondrial function, detoxification of numerous toxins such that they can be excreted from the body, etc. It is an essential factor for the function of almost all cells. GSH has antiviral effects for several different viruses including HIV and murine retroviruses. GSH has been called the �master antioxidant.� The major producer of GSH is the liver but it can be synthesized in several organs. b) Cysteine administration can increase the synthesis of GSH by providing the key precursor (especially in the setting of cysteine / GSH deficiency). c) There are several ways to administer cysteine. These include N-acetyl-cysteine (NAC), whey protein and actual GSH. NAC is given orally, is well absorbed and is converted to cysteine in the body. The doses vary widely ranging from 150 mg to several thousand milligrams per day (a common dose is 600 mg twice a day). Many brands of whey protein are available. There is evidence that �lightly denatured whey protein� (which has undergone a specific filtration process and has not been overheated) is more biologically active and has markedly improved protein content in a usable form that can raise GSH levels. Some popular brands are ImmunoPro (5 grams per scoop) and Immunocal (10 grams per pouch). These whey protein concentrates also contain lactoferrin which has been shown to have antiviral properties (including HIV). The actual GSH molecule is not well absorbed via oral administration (although there is a lipid coated preparation that considerably improves absorption). It can be given IV as well as several other routes of administration. Either whey protein or NAC have probably been the easiest, least expensive and most popular methods for increasing cysteine intake.
7) Vitamin C a) Lipo-Spheric Vitamin C (1000 mg per packet). Suggest 1 � 4 packets per day. b) This new formulation entails vitamin C which is covered with a lipid coating that allows for excellent absorption from the GI tract (98% absorbed). Blood levels and tissue levels are greatly enhanced, thus the results are similar to IV vitamin C but there are less GI side effects than conventional forms of oral vitamin C. c) Vitamin C has numerous properties that may be effective in this setting: it is an antioxidant, helps recycle GSH, etc. One of the most important properties is the ability to stabilize and recycle BH4 (tetrahydrobiopterin). BH4 is a critical cofactor for the functioning of the nitric oxide synthase enzymes. If BH4 levels are low, the enzyme becomes �uncoupled� and instead of synthesizing nitric oxide it switches over and produces superoxide (a very powerful free radical). The superoxide that is produced (by reacting with nitric oxide) forms peroxynitrite which results in BH4 degradation and inactivation, thus a vicious cycle is initiated. By restoring BH4 levels, ascorbic acid can break the cycle and diminish oxidative stress. Low BH4 may be a major player in oxidative stress and ascorbic acid can restore these levels to normal.
8) Other (miscellaneous) a) Various other supplements may be helpful. Several are important cofactors for enzymes in the methylation pathway, formation of glutathione or both. These include selenium, zinc, magnesium and vitamin B6. b) Antioxidants: various supplements that scavenge free radicals, reduce oxidative stress and reduce oxidized glutathione back the reduced form of glutathione. Examples are alpha lipoic acid, vitamin C, vitamin E, and numerous plant based polyphenols. c) Other substances may directly inhibit retroviruses. One example is curcumin (such as Meriva SR). d) Omega 3 fatty acids e) Vitamin D f) Probiotics: help maintain a healthy GI tract
Basic Supplement Protocol for XMRV-associated methylation abnormalaties , glutathione depletion and oxidative stress
1) Vitamin B12 injections 1cc (1000 micrograms) weekly or sublingual methyl B12: 5000 micrograms per day. 2) Folinic acid 800 micrograms: two � three per day or Metafolin (methylfolate) at same dose. These two can also be combined. 3) Glisodin (SuperGlisodin): 250 mg � 500 mg twice daily 4) Broccoli sprout (Vitalica): one or two capsules daily 5) TMG: 1000 mg twice daily 6) Biologically active whey protein: ImmunoPro one to four scoops per day or Immunocal one to two pouches per day. An alternative to whey protein is NAC 600 mg: two to four per day. 7) Lipo-Spherical Vitamin C: 1 � 4 packets per day
(All of these can be obtained from various Internet sites)
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