DRB5 DRB5*- DRB5 DRB5*- HLA allele interpretation for all loci based on IMGT/HLA database version 3.3
Thanks to whoever can help me with this !
Gary
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seekhelp
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Gene 1: 4-3-52C
Gene 2: 13-6-53
I 'think' this is accurate based on Dr. S' legend in his book 'Surviving Mold' Gary. It's hard to connect if the DRB3 and DRB4 gene numbers tie to the top set of bottom set of numbers. Hopefully it's the way I wrote it as 4-3-53 is multi-susceptible and 13-6-52C is bad as well (mold-susceptible). That would be a BAD combination to have two sets of genes like his.
I'm no doctor - just doing my best. I'd ask your doc for further interpretation. Good luck.
I've got a million questions on these issues as well, but don't have thousands to pay Dr. S to get them. Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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karenl
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Did you ever try hydroxy B12 shots, that helped me a lot.
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momlyme
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Sent PM... Gary, if you don't mind, you can post the interpretation I sent you.
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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lymetwister
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Cut & Paste from MomLyme Below: My question would be what to do with the given interpretation below:
Sorry it's not better news Gary - I think you probably suspected it would not be!
So to summarize: Your HLA types are: 4-3-53 (the dreaded)- Shoemaker says this is the one that keeps people sick with 0402 being the third worst B1:04 you can have!
and 13-6-52C
-------------------- ~Heather
Praying for recovery... for all who are suffering.
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I have similar results. I think many of us on here probably have a genetic component that keeps us ill.
My suggestion would be to really focus on detox. I think these results mean that your body will have a difficult time naturally eliminating the toxins from the dead bacteria or from mold. Binders are supposed to be helpful such as cholestryrime.
What does your doctor say?
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feelfit
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MY results..interpreted by Momlyme....she was spot on with my doctors interpretation as well...Gary, makes sense, I guess, why we have all of the crazy head stuff. Recirculating toxins....uggggh. Much, much harder for us to get well with this genotype Posts: 3975 | From usa | Registered: Aug 2007
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seekhelp
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Can these really be looked at in isolation as you're doing MomLyme? I thought all three numbers in the gene chain combined is relevant and not a single (i.e., DRB) in isolation? Did a doc confirm? I assumed when you look at Dr S' Rosetta Stone legend that all three numbers need to match on the table to be applicable???
I don't have these genotypes Feelfit and I can't get well. Maybe there's more to it. I've got PLENTY of head problems like you and Gary.
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feelfit
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Mr. Seekhelp did a correct interpretation too Posts: 3975 | From usa | Registered: Aug 2007
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momlyme
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I am doing the interpretation using Dr. S's new book Surviving Mold - pages 714-716
I know I am doing them correctly because I am coming up with the same results that the doctors are feeding back.
FYI, I have done about 25 now for people on Lymenet, facebook and MDJunction and many people who have been treating lyme for a long time are mold or multi-susceptible.
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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feelfit
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I'm sure there is more to it Seek, just sayin', it definitely adds to the problem....I'm sure blood flow to the brain is a MAJOR player as well....*sigh*
i hope that all of us find our way out of this hell, one thing is certain, we're all determined fighters Posts: 3975 | From usa | Registered: Aug 2007
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seekhelp
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I just tried calling Dr. S' office to get clarification, but they didn't help. Again, can anyone say with absolute certainty that it is not necessary to have all THREE components of an HLA code to fit his profiles. The book isn't clear. I have read no arguments for or against, but it sure as hell makes sense that a code would need to be complete.
I really want to know if the 04-03-52C would have any meaning if one has just the 04-03 components in the beginning, but a different number than 52. Know what I mean? When you open a combo lock, you need ALL THREE numbers. Has anyone here actually seen Dr. S and asked?
I fear we're being too broad here and perhaps guessing meaning when the real population may be smaller if all three are needed. Of course, this doesn't apply to everyone who posts. Otherwise, why would he set his table up with five columns if all were not relevant?
Here's the link to his info for those who need clarification on my question:
feelfit
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Seek..my brain is too overwhelmed to figure this out on my own. I can't even understand your thoughts...though I'm sure that they're clear to others.
All I know is that my doctor gave me the same outcome as Lymemom did. Exactly.
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momlyme
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In Surviving Mold (page 715):
Each individual will have two sets of three alleles, unless the DRB1 is 1, 8 or 10. Those patients will only have a DQ and won't have DRB 3, 4, or 5.
Each individual with a DRB1 other than 1, 8 or 10 will have a DQ and one other allele from DRB 3, 4, 5. If you are expecting to find two entries in say DR 3, 4, 5 but only find one, the patient is homozygous for that allele and only one allele will appear on the PCR.
>>end quote from SM
Hope that helps!
It seems clear to me and I have decoded 20+ with no difficulty. You must understand and accept that if your DRB1 is 1, 8 or 10 -- you will only have the 2 markers!
I wish I could find an online reference that lists Dr. S's table of HLA DR Haplotypes that you can find on page 716 of SM. If anyone knows of a link, this may help seek understand the haplotypes.
I found it interesting... I don't trust it completely because wikipedia can have unreliable information. It did have some interesting HLA associated diseases.
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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My DRB1 is 1 and so I only have the 2 numbers... well.. I have 1-5 (low msh) and 17-2-52B which is not on the rosetta stone.. although if you take just the first two numbers that would be a mold type...
Gary, you also have to check the other markers.. C4a, C3a, Leptin, MSH, VIP, MMP-9, TGF-beta1..... they are work together to get a bigger picture. Like for me. I have a c4a over 20,000 which is basically showing me I have massive inflammation probably from mold exposure.
Also, I have high MMP-9 and Low Vip and low MSH... this gives us a bigger picture.
I have been on csm now for 2 months with no improvement so now I have to test my house with an ERMI to make sure that my environment is not constantly posioning me...
This is something to defintely look into.. I taked to you about this before and for those of us who don't get well with anything.. you have to look to WHY!!!!!!!
-------------------- "You'll be surprised to know how far you can go from the point you thought it was the end" Posts: 946 | From Massachusetts | Registered: Apr 2008
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momlyme
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17-2-52B is in the table I mentioned - page 716 of Surviving Mold. It is a valid haplotype.
The Rosetta Stone does not give haplotype chains but it breaks down each of the DRB1, 2, 3, 4, 5 into what they stand for... then you use the table to put together the correct haplotype chain.
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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but 17-2-52b is not on the rosetta stone as anything significant.... so what does that mean for me as far as HLA types. I hae the 1-5 which is on the rosetta... but my second one is not on there as anything.
-------------------- "You'll be surprised to know how far you can go from the point you thought it was the end" Posts: 946 | From Massachusetts | Registered: Apr 2008
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seekhelp
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UnexpectedIlls is the only one who gets what I'm saying. Momlyme, look at this example:
PROVEN multi-suspectible gene per Dr. S in Suviving Mold: 4-3-53
Now if my gene is 4-3-52C, why would you believe I have any issues? Nowhere does Dr. S say having just a 4 in the first column or just a 3 in the second has any meaning. I thought I need ALL THREE numbers in sequence to fit his profile.
I believe you may be misinterpreting his Rosetta Stone in that respect. If just having a 4 in the DRB1 column is meaningless without the other two figures lining up, then.......
I really don't know why his office can't just tell me. I guess they want a ton of $$$$. lol. Same ole' crap.
If your logic is correct, basically anyone who has a DRB1 of 4,17,11,12,13,14,15,16,17, or 18 would have detox issues? What's left? seems too broad, huh?
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momlyme
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seek - the table I keep talking about would tell you that a 4-3-52C is impossible.
The only combinations with DRB1 of 4 are: 4-3-53 4-4-53 4-7-53 4-8-53
with 4-3-53 being the worst of the 4 haplotypes above.
Now if you break 4-3-53 down even further: 0401-3-53 is the worst of the worst 0404-3-53 is second worst 0402-3-53 is the third worst
A close fourth is 11-3-52B - You can recognize this type by long arms, long fingers, athletic, hyper-flexibility
I did email with someone at Dr. S's office to make sure I was interpreting these correctly when I was doing my first few... it was a little confusing. I have done a lot and it has gotten pretty easy. And yes, each marker stands on it's own as well as fits into a HLA DR Haplotype.
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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so my 17-2-52b even though not on the actual stone means I have the mold type right.. because I have the 17 and 2.... this is so confusing
-------------------- "You'll be surprised to know how far you can go from the point you thought it was the end" Posts: 946 | From Massachusetts | Registered: Apr 2008
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momlyme
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quote:Originally posted by UnexpectedIlls: so my 17-2-52b even though not on the actual stone means I have the mold type right.. because I have the 17 and 2....
Yes, exactly.
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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Maybe there's more to it. I've got PLENTY of head problems like you and Gary.
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