Timaca
Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Hey early bird! Ya beat me to it! Good for you!
Here are some quotes.
"While the increased amount of inactivated bacteria resulted in lymph node enlargement compared to control mice (Figures 3C, 3D), the enlargement was significantly less (p = 0.001) than that seen with viable Borrelia (Figure 3D).
Thus, we conclude that lymphadenopathy during B. burgdorferi infection is caused by the accumulation of viable spirochetes in lymph nodes."
In other words, they put lots of dead spirochetes in the mice and although some lymph node swelling was noted, it wasn't near the problem that live spirochetes caused.
So, lymph node swelling- lymphadenopathy- can be caused by LIVE spirochetes hiding out in lymph nodes.
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"Together with the strong antigen-specific B cell responses measured by hybridoma generation, the results suggest that Borrelia-infection induces a specific, albeit largely extrafollicular B cell response as a result of the accumulation of live B. burgdorferi in lymph nodes."
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"From these results we hypothesize that these effects of B. burgdorferi on the Borrelia-specific B cell response constitute a novel immune-evasion strategy."
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"B. burgdorferi causes spirochetemia, but its primary means of dissemination is via migration through host connective tissues and extracellular matrix [59] .
This is consistent with our finding of progressive involvement of the ipsilateral, but not the matching contralateral lymph nodes of the host (Table 1).
...
Furthermore, it is notable that tick-borne infections also failed to induce a significant B cell response in the spleen (data not shown)."
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