posted
I took both of them, along with mino, flagyl, biaxin, and diflucan.
I didn't have any problems with that cocktail besides the herx from rifampin. I never really noticed anything from the cefdinir - no herx, no additional relief from symptoms. I alternated cipro and rifampin, but never took those two together.
Rifampin doesn't play nicely with others. It can cause heart irregularity in some people(prolonged QT interval IIRC). It lowers the effectiveness of virtually all other abx you might be on.
Posts: 146 | From Maine | Registered: Aug 2011
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Does lowering the effectiveness include mepron because I'm to be going on mepron and after a month rifampin to deal with the babesia - bartonella dance?
Posts: 705 | From WA state | Registered: Jul 2011
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WPinVA
Frequent Contributor (1K+ posts)
Member # 33581
posted
My LLMD didn't want to put me on Rifampin and Mepron together. So I was taken off of Rifampin to go on the Mepron.
Posts: 1737 | From Virginia | Registered: Aug 2011
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Interactions between your selected drugs rifampin ↔ atovaquone
Applies to: rifampin, Mepron (atovaquone)
GENERALLY AVOID: Coadministration with a rifamycin may decrease the plasma concentrations of atovaquone. The exact mechanism is unknown but may be related to the enzyme-inducing effects of rifamycins. In 13 HIV-infected volunteers, administration of atovaquone suspension (750 mg orally every 12 hours) with rifampin (600 mg orally every 24 hours) resulted in a 52% decrease in the average steady-state plasma atovaquone concentration and a 39% reduction in atovaquone half-life (from 82 hours to 50 hours) compared to administration without rifampin. Similarly, concomitant administration of rifabutin has been shown to reduce atovaquone plasma concentrations by approximately 34%.
MANAGEMENT: The use of atovaquone in combination with rifampin or rifabutin is not recommended. The same precaution may be applicable to rifapentine, although clinical data are lacking.
It doesn't show in the text, but it's listed as a 'moderate' interaction.
So it looks like something to avoid, if possible. If you need to treat both babs and bart, however, and you can't take the *floxacin family (cipro, levaquin, etc) then it's probably worth the interaction.
Bart can be very nasty if left untreated.
Posts: 146 | From Maine | Registered: Aug 2011
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