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» LymeNet Flash » Questions and Discussion » Medical Questions » Is anyone familiar with a medicine DEC for filarial worms

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Author Topic: Is anyone familiar with a medicine DEC for filarial worms
Haley
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Has anyone taken DEC or Diethylcarbamazine? Apparently this kills the adult worms.
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WhitneyS
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Hey I just took this...maybe we have the same Dr? I hadn't been able to find any info on it at all.

I didn't really have any reactions to it.

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jellybean
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I have taken this and it helped me more than any other parasite med. It got rid of my ear pain, swollen glands, energy. I also sometimes felt like I was being "bitten" but I would look and there was nothing on my skin. It got the "biting" to stop too.

The bad news is that about 2 months after I stopped it (per my doctor), the symptoms started coming back so I'm back on it.

It's helped a couple friends of mine too. I ordered it from magicpharma.com and there you have to search for hetrazan to get it to come up.

I traveled a lot before I got sick so we're not sure if I had this parasite before I got lyme or not. But since we're hearing that ticks also carry filarial worms, I think many people might benefit from this drug.

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jellybean
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I meant to say it IMPROVED my energy. It didn't get rid of my energy. :-)
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dal123
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Do u have to have a prescription for this to order from magicpharma.com? I have travelled lots, in fact spent six weeks field mapping from southern Mexico up through northern Mexico to new Mexico and ate at lots of delicious outdoor local yokel ethnic restaurants.

Only 3 mg of ivermectin today sure dumped a lot of strange stuff in BM's.

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Haley
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Jellybean. What other parasite meds did you take?

I've always wondered about this med.

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annxyzz
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Questions :
Does this DEC kill all of the worms- adult and
babies ?

How much is needed and for how long ? Is it a risky med ?

Can it totally eradicate the worms ?

Where can it be purchased ?

ANY INFO WOULD BE HELPFUL .

I am asking because I took ivermectin for three months , and my "asthma " symptoms went away and my twitching . I have been off it for two months, and symptoms are returning now, which proves the ivermectin DID work !

How long does it take to get rid of these worms ? Or , are they impossible to eradicate ?

There are many here who need this info ! Thanks ..

--------------------
annxyzz

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jellybean
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Someone PM'd me a message re: the expiration date of these meds which I ordered ONLINE from www.magicpharma.com They are not expired meds. the stuff i just got doesn't expire for 2 years (2014). The reason we have to order from an overseas pharm is because they don't sell it in the USA (because we don't have filarial worms here, hee hee).

My dose was 2, twice/day and then I worked up to 3 twice and eventually 4 twice (when I wasn't on any other drug). At first I took it for 2 months, I stopped, symptoms returned, then I took it for about 3-4 months and this time I'm thinking I'll stay on it for 6 months. We'll see what my doctor thinks. And FYI, my LLMD was the person who originally suggested this.

I've read a couple different studies on DEC & filarials. Some say it kills them all (not in my experience), some say it kills the babies and that you should re-treat every 4-6 months for 5-7 years because that way the adults eventually die of old age and you keep killing the babies by retreating. Apparently the babies stay in the bloodstream for up to a year or so and DEC kills them there.

Some studies say the most effective treatment is DEC & Albenza together. Some suggest DEC & ivermectin. Ivermectin didn't do much for me , albenza did some good, but for me, nothing worked like DEC.

AND you don't need a prescription with magicpharma, you just have to tell them you have symtpoms of filarial parasites or that your doctor "suggested" you try this and they'll send it.

Is this med risky? I don't really know. I don't think it is any worse than the other parasite killing drugs we take, but I really have no data on that.

my filarial symptoms are: swollen lymph nodes, sore throat, fatigue, ear pain, shooting pains in my legs when I get a burst of adrenalin, and little tiny linear bruises or hemotomas on the tips of my fingernails, just where the pink turns to white. When my doc saw those that's when he suggested DEC.

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jellybean
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oh and my other symptom is the "biting" sensations which seem to occur mostly at night and increase with the full moon and sometimes with the new moon. They happen most often on my ribs, sometimes on my lower legs and when I was the sickest, I felt a weird sensation across the bridge of my nose occasionally. I later read that you can sometimes feeling them crawling across the bridge of your nose. Who knows if that's what it was but I didn't like the feeling.
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CD57
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Jellybean and other, Do your symptoms suggest that these bugs are in the CNS because they seem "neurological" --or are these bugs in other places and the system just happens to show up that way? I always thought parasites weren't really attracted to the CNS.
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sparkle7
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FYI- Some info I was able to find. I'd like to study it further but I have some other stuff to do now.

Diethylcarbamazine
From Wikipedia

Diethylcarbamazine (DEC) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Uses
DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because of the intense and unbearable itching associated with the dead subcutaneous parasites.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.

Mechanism
DEC is an inhibitor of arachidonic acid metabolism in filarial microfilaria. This makes the microfilaria more susceptible to immune attack.

Trade names
Hetrazan
Carbilazine
Caricide
Cypip
Ethodryl
Not�zine
Spatonin
Filaribits
Banocide Forte

---

http://www.stanford.edu/class/humbio103/ParaSites2004/Filariasis/intro.htm

Diethylcarbamazine (DEC) is an effective drug for killing microfilariae, but is slower in killing adult worms. It is usually administered at the rate of 6 mg/kg of body weight. DEC has been applied to table salt in both China and Tanzania as a mass treatment program.

Ivermectin may be taken concordantly with DEC for better long-term suppression of microfilaremia. Superficial wounds can be treated with antibacterial cream to prevent further infection.

---

http://www.biomedcentral.com/1475-2883/content/4/1/4

Results
DEC administered alone to BALB/c mice resulted in a rapid and profound reduction in circulating microfilariae within five minutes of treatment. Microfilarial levels began to recover after 24 hours and returned to near pre-treatment levels two weeks later, suggesting that the sequestration of microfilariae occurs independently of parasite killing.

Pre-treatment of animals with dexamethasone or indomethacin reduced DEC's efficacy by almost 90% or 56%, respectively, supporting a role for the arachidonic acid and cyclooxygenase pathways in vivo.

Furthermore, experiments showed that treatment with DEC results in a reduction in the amount of COX-1 protein in peritoneal exudate cells. Additionally, in iNOS-/- mice infected with B. malayi microfilariae, DEC showed no activity, whereas the efficacy of another antifilarial drug, ivermectin, was unaffected.

Conclusion
These results confirm the important role of the arachidonic acid metabolic pathway in DEC's mechanism of action in vivo and show that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1. Moreover, we show for the first time that inducible nitric oxide is essential for the rapid sequestration of microfilariae by DEC.

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glm1111
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FYI,

Treating parasites is an ongoing lifetime endeavor. Some of these worms have laid hundreds of thousands of eggs a day. If just one egg is left over, the cycle will start all over again.

I have read that in third world countries, Ivermectin has to be taken for life for some of the Filarial worm infections.

The same would hold true for herbs and or salt/c. These parasites get into the organs and tissues.

I used to have SEVERE rush me to the hospital asthma which has completely gone away with tx, however, I will always do maintenance antiparasitics for life.

Everyone here needs to do intense research on the life cycles of these parasites. I take extra cloves to kill the eggs. Not sure if any pharma drugs kills all the eggs.

IMO, parasites/worms are at the crux of chronically ill Lyme patients and most people with degenerative diseases.

Gael

--------------------
PARASITES/WORMS ARE NOW
RECOGNIZED AS THE NUMBER 1 CO-INFECTION IN LYME DISEASE BY ILADS*

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annxyzz
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bump

--------------------
annxyzz

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Haley
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I find this sentence interesting:

Results
DEC administered alone to BALB/c mice resulted in a rapid and profound reduction in circulating microfilariae within five minutes of treatment. Microfilarial levels began to recover after 24 hours and returned to near pre-treatment levels two weeks later [rant] , suggesting that the sequestration of microfilariae occurs independently of parasite killing.

I can feel this happening when I treat with Ivermectin. It's usually approximately 24 hours later that I feel them coming back.

I guess this article is saying that if you don't kill the adults you're screwed, but it doesn't sound like the DEC kills the adults either. I read a book that says they must be surgically removed.

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fourwinds
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quote:
Originally posted by Haley:


I read a book that says they must be surgically removed.

Hmmm, how ???
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MannaMe
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glm111, where do you get the extra cloves you are taking? Is it in capsules or just the spice from your cupboard?
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annxyzz
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I find it interesting that DEC had been added to TABLE salt in china as a mass treatment effort .
Implies it must be fairly safe.

Manname you can order cloves from swansons or most herb places - puritan etc...

--------------------
annxyzz

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annxyzz
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Gael, how many clove capsules do you take ? Everyday or sporadically ? Do you think the cloves really kill eggs ? I have not read that .

From what I am reading, combining this Diethylcarbamazine with ivermectin is supposedly more effective .

--------------------
annxyzz

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Love my kids
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I have taken Ivermectin and DEC (plus Alinia in the past) as well as Albenza, Pyrantel and Biltricide as part of Dr. K parasite protocol.

DEC is on deck now for about a month. Aside from frequent loose, smelly stool, I don't notice as much on it as the others.

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Haley
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Love my kids -

Was it difficult to get a script? I've read that doctors in USA don't prescribe this. Maybe I read it wrong.

How long have you been on this type of protocol?

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Love my kids
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My doc did prescribe it but Magic Pharma never asked for the copy. They did ask if I HAD an Rx, but didn't want it.

I have been on the Dr. K protocol for longer than he recommends with that being 6 weeks with meds taken in a particular order (Biltricide, Ivermectin, Pryrantel, Albenza, DEC or Alinia. My doc has me staying on DEC longer than the two weeks per Dr. K since I have had a lot of crap come out of me (pardon the punn). I am now armed with more info about parasites from reading this board recently so wonder if I should go back on some of the meds from earlier in the protocol? I will be asking him next appt.

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sparkle7
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Interesting. I'm going to give this more thought. You could try alternating the anti-parasite herbs with the drugs. I don't know if you could take both at the same time since the herbs may have a counter-productive effect with the drugs. Sometimes that can happen between herbs, drugs, or supplements.

I would just consider it a lifetime thing to take the anti-parasite drugs &/or herbs. I stopped for about a year & mine came back. I thought other things were making me ill like metals, methylation issues, EMFs, yeast, stress, etc. but now that I think about it - it was probably the bugs.

I don't see alot of people trying Auravedic, Chinese or Amazon herbs for parasites. All of these cultures have alot of experience with parasites & have many different herbs that can be used.

Cloves seem good but I don't know if they can get into areas like the brain, lungs, vaginal areas, blood, etc. I'd have to study it. Cloves have other benefits, too, but it seems bugs are good at building resistance to things we use to kill them.

I just read an article that the GM crops treated with Round-Up are starting to get resistant bugs. It seems they can always outwit us no matter what we do. Our best chance may be switching up the treatments...?

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sparkle7
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fyi -

http://www.nationofchange.org/report-nature-may-soon-overcome-monsanto-super-rootworms-destroy-crops-1340975688

Published: Friday 29 June 2012

Amazingly, western corn rootworms have virtually no problem gobbling up Monsanto�s modified maize crop, as they have developed a serious resistance to the very crops designed to kill them.

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