posted
Just curious if anyone actually knows of another that was officially diagnosed and successfully treated with a cross reactive illness on Bands 23,41,58- All three are known to cross react.
Just curious!
Thanks!!!
Posts: 61 | From NC | Registered: Aug 2011
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posted
You mean treated for something other than Lyme? (like what?)
Are you sure 23 is cross-reactive? I never heard that.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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Sammi
Frequent Contributor (1K+ posts)
Member # 110
posted
Which lab did your Western Blot? Labs such as Quest and LabCorp do not list all the Lyme-specific bands.
Band 23 is specific for Lyme disease. What other illness do you think would show on the Western Blot?
Posts: 4682 | Registered: Oct 2000
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Parvovirus b19 for Band 23- is one that I know of.
I have found a bit of research over the past year re: cross reactivity for Band 23, as well as the fact that, indeed, it is not a Lyme specific band if others have been found to cross react. Only reason I know is that I had a severe case of Parvo not long before the bites and continued increasing illness.
I have had a few different tests. Lapcorp- pos. band 23 (other posts), Duke-not provided bands- so I don't know what showed up- but positive Elisa, Igenex- 23,41,58 - all which can cross react- the only question was the ind. on 39-and 23-25 which would be the clencher-
I have had great advice from so many on here- it's just so difficult to narrow down- and I do so wish for a true answer. On 3rd week of doxy- thinking of doing another Igenex. I know everyone thinks it's a shoe in- but- I read so many studies to the contrary- and- I am one who really would like def. "proof" to help rule out other possible challenges...
Posts: 61 | From NC | Registered: Aug 2011
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"Among the 11 B19V-infected patients, positive Borrelia IgM was seen in 9 (82%). Altogether, combined-positive serologies with the two microbes occurred exceedingly frequently. As there is no epidemiological link between the two infecting pathogens, the most plausible explanation was polyclonal stimulation. Interpreting data strictly and including only definitive diagnostic findings for B19V and positive IgM findings for Borrelia, it can be concluded that an immune activation giving rise to positive IgM results for Borrelia ensues in over half of the B19V infections"
"Using multiple approaches, we present data to show that acute B19V infection gives rise to polyclonal B-cell activation toward nonrelated bacterial antigens. This phenomenon was documented by (i) medical records for two patients in whom polyspecific IgM reactivity was observed; (ii) retrospective analysis of the laboratory data on all samples studied in 2008-2009 in our clinical microbiology laboratory simultaneously for both B19V and Borrelia antibodies; (iii) reanalysis of 50 samples from 33 subjects with verified B19V primary infection for Borrelia, Campylobacter, and Salmonella IgM antibodies; and (iv) B19V serological analysis of 12 patients with confirmed borreliosis. Taken together, we observed that acute B19V infection does elicit IgM antibodies to multiple microbial antigens. This phenomenon occurred commonly, at a frequency ranging from 75% to 86% (Table (Table2).2). Of further clinical importance is the finding that these antibodies may persist long after acute infection in many subjects (38% [Table [Table3]),3]), at individually alternating levels. In comparisons of individual patients, the bacterial IgM persistence did not correlate with that of specific viral IgM, arguing against simple cross-reactivity. In one case report a patient with B19V infection was mistakenly treated for Lyme disease (5). In that study the misdiagnosis was based on a positive Borrelia IgM EIA result, confirmed by immunoblotting. Although also our case 1 presented with a positive Borrelia EIA and immunoblot assay, the misdiagnosis of acute borreliosis was avoided because IgM antibodies were simultaneously reactive with multiple bacterial antigens. To our knowledge, our study is the first systematic report substantiated by experimental data to show that acute B19V infection may adversely affect bacterial serology, especially for Borrelia. Borrelia burgdorferi, Campylobacter, or Salmonella bacterial infections are implicated in arthritides or arthralgias considered secondary borreliosis or ReA. On the other hand, the possibility of coexistent Lyme disease and B19V infection should be kept in mind (8). Our data and earlier publications (5, 8) illustrate potential pitfalls in bacterial serology and the need for scrupulous microbiological assessment, aiming at appropriate treatment and correct prognostic assessment."
"Of interest, acute borreliosis does not appear to lead to dubious results in B19V serology. All samples tested showed B19V prior immunity or were unambiguously seronegative. This observation renders the chance of antigenic cross-reactivity (bidirectionally) between the two unrelated microbes highly unlikely."
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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Sammi
Frequent Contributor (1K+ posts)
Member # 110
posted
I can understand your wanting proof, many people do. Unfortunately, with tick-borne diseases the tests are not completely reliable.
Hopefully you have a knowledgeable doctor who is taking into account your hisotry, symptoms, and test results.
Posts: 4682 | Registered: Oct 2000
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posted
No one has taken it seriously, or- you know, it's a false positive, or something else caused it. Hence, my post.....
Posts: 61 | From NC | Registered: Aug 2011
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posted
Yes Sammi- I finally do- Thank you-and- I think I am switching from Doxy to Mino this week. My face is so burned and I cover up completely and in the shade! Posts: 61 | From NC | Registered: Aug 2011
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Sammi
Frequent Contributor (1K+ posts)
Member # 110
posted
Lunaangel, I am glad you have a good doctor. It is very important.
I was extremely sun-sensitive to Doxy also. I just wrote on another post that my knuckles would get burned from the sun coming into the car when I was driving.
Minocycline does not cause these problems for me. I always wear sunscreen when outside. I hope it works well for you.
Posts: 4682 | Registered: Oct 2000
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Band 23-25 "outer surfce protein C (OspC) specific for Bb. Can be an early band.
Band 41 (I think we've all learned this one!) Flagellin protein of all spirochetes........ this is the most common borreliosis antibody
Band 58 - unknown but may be a heat shock Bb protein - check for viral infections.
Posts: 396 | From EAPennsylvania | Registered: Dec 2007
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