"The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.
Strandhagen E, Zetterberg H, Aires N, Palm�r M, Rymo L, Blennow K, Landaas S, Thelle DS.
Source
Department of Medicine, Cardiovascular Institute, Sahlgrenska University Hospital/Ostra, SE-416 85 G�teborg, Sweden. [email protected]
Abstract
Some methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are associated with hyperhomocysteinemia. Trials have shown a plasma homocysteine raising effect of coffee. We determined the effect of a daily intake of 600 ml coffee and a supplementation of 200 microg folic acid or placebo on plasma homocysteine (tHcy) with respect to the MTHFR C677T and A1298C polymorphisms. One hundred and twenty healthy, non-smoking men (22%) and women (78%) aged 29-65 years, took part in a controlled, randomized, blinded study with two intervention periods: i) a coffee-free period of three weeks, ii) 600 ml coffee/day and a supplement of 200 microg folic acid/d or placebo for four weeks. The results showed that tHcy at baseline was significantly higher for the 677TT genotype group compared to the 677CC genotype group (p=0.0045) and that this group responded with significantly larger increase in tHcy upon coffee exposure than the 677CC and 677CT genotype groups (p=0.0045 and p=0.0041, respectively). Supplementation with 200 microg folic acid compared to placebo reduced the tHcy increasing effect of coffee in the 677TT genotype group. The A1298C polymorphism did not affect tHcy concentration significantly at any stage in the study. In conclusion, the homocysteine increasing effect of coffee is particularly seen in individuals with the homozygous 677TT genotype. Supplementation with 200 microg folic acid/d decreases this tHcy increment."
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
sooo...if you drink coffee you should take folic acid?
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
| IP: Logged |
posted
what does this mean? i have one copy and my kids have two. my lyme brain can't comprehend the article.
Posts: 47 | From usa | Registered: Nov 2011
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
I'm thinking that if you have MTHFR stay away from coffee. I have 2 copies of C677T, not good. I am addicted to coffee and drink a lot of it. I've suspected for a long time that it is not doing me any good but I'm addicted!
Coincidence that people with MTHFR tend to have problems with addiction!
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
The way I interpreted the article too was that coffee was a bigger problem for C677T than 1298C.
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
posted
In conclusion, the homocysteine increasing effect of coffee is particularly seen in individuals with the homozygous 677TT genotype. Supplementation with 200 microg folic acid/d decreases this tHcy increment.
---
Just take folate. I'm not sure which is the best form - I have been taking folinic acid with the simplified protocol.
---
Try some tea or Caffix instead of coffee. Celestial Seasonings used to make one called "Roastaroma" that is a bit like coffee.
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
So I can keep my coffee habit? Yay!
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
posted
Could you please elaborate: "Coincidence that people with MTHFR tend to have problems with addiction!"
This is relevant for family history reasons. I might be able to reach out to some family members and help, but I would need a source for the information.
Thanks.
-------------------- Garden
"Fibromylagia" for 8+ years Pos IgeneX WB per both Igenex and CDC Pos Neuroscience MyLymeImmuneID Started tx for Lyme in March 2011 Posts: 245 | From East Coast | Registered: May 2011
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
I'm pretty sure it is on the list of symptoms on MTHFR.net. I know I've seen it in a few places that list MTHFR symptoms and I believe mthfr.net was one of them.
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
C677T (double copy) = can't PROCESS folic acid.
Also -> limited ability to make BH4...needed to make several neurotransmitters and detox ammonia.
Need Deplin Rx or FoloPro by Metagenics. 5-methylfolate is the active form of folic acid/folate.
No use giving folic acid if one can't process it.
Homocysteine can be lowered other ways too..B6= PLP/P5P (active form...sublingual).
B12 - if not missing the intrinsic factor.
and TMG or just eat sugar beets.
Homocysteine + LDL is a bad combo.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
posted
Does the A1298C mutation cause one not to process folic acid as well...I"m just not clear on that. thanks.
Posts: 287 | From somewhere | Registered: Oct 2011
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic