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» LymeNet Flash » Questions and Discussion » Medical Questions » MTHFR questions and 23andme

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Author Topic: MTHFR questions and 23andme
prayerworks
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Member # 37602

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For those of you who have gone the MTHFR route, can you give some guidance. I want to be tested to see if I detox well and what other issues I have and which meds and supplements will work better for me.

In researching, I found 23andme which is fairly affordable. But I am not sure exactly how it works.

I also went on another website (Yasko) and I was overwhelmed with the amount of tests available there and some were really expensive.

Has anyone here had any experience with 23andme? What about Yasko?

Any suggestions or guidance would be most appreciated.

Thank you!

Posts: 138 | From US Virgin Islands | Registered: May 2012  |  IP: Logged | Report this post to a Moderator
Razzle
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If all you want is MTHFR testing, you can do that at LabCorp or Quest and insurance likely will cover it.

Problem is, there are many other genes involved with methylation, which is why the other tests are more expensive.

There is some overlap between Yasko's Methylation Panel and 23andme.com, but some tests are unique to each.

Which test to get should be determined by what information you want to find out.

If you want to focus on methylation issues, Yasko's Methylation Panel is the way to go. If you're more interested in a general overview of your genetic profile, then 23andme.com is the way to go.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

Posts: 4166 | From WA | Registered: Feb 2011  |  IP: Logged | Report this post to a Moderator
Tammy N.
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Side note -- 23andme makes you sign away rights to your DNA (or something to that effect), so that stopped me dead in my tracks.

When I do move forward with testing, I plan to do Yasko's.

Posts: 2238 | From East Coast | Registered: Jul 2010  |  IP: Logged | Report this post to a Moderator
VV
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"23andme makes you sign away rights to your DNA (or something to that effect), so that stopped me dead in my tracks."

Not from what I remember. It seemed like their use of your sample was up to you. They ask a series of questions that you do not have to agree to regarding your sample. I said yes to all because I'd rather see the information used in a broader context, as that will improve the purpose of the testing.

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cozynana
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So, let me get this right. Use the 23andme if I am looking for genetic traits I have and use the Yasko's methylation panel for the MTFR issues.

And, the Yasko's is more than likely paid for by ins. and the 23and me is not. Do I have that right?

If I have this right, are there other reliable ins. covered tests for genetic mutations?

I have really good ins. and would like to find the testing I need and ask my GP to order it.

I think next time I see him we are going to do the rheumatoid arthritis one.

We know I have autoimmune, but don't know the whole picture yet.

I know I have the HLA DQ2 gene for celiac, but the testing was through a naturopath and was out of pocket.

I would like to know what genetics I have because my dad has CIDP which is a relative to Gulliane Barre'.

Many of his cousins and one uncle have neurological issues. I seem to also.

And the saga goes on, (sigh). Will this puzzle ever end?

Posts: 620 | From Ks | Registered: Oct 2011  |  IP: Logged | Report this post to a Moderator
kgg
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If you are interested in how you detox. Here is a link to see what the report would look like: http://www.gdx.net/core/sample-reports/Detoxi-Genomics-Sample-Report.pdf

It shows phase I & phase II detoxification.

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Razzle
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DetoxiGenomic test does not look at much having to do with methylation...no MTHFR.

It is a good test, though, because it does look at the rest of the detox pathway enzymes that Yasko's test does not look at...

And insurance may cover it as well.

Yasko's test may or may not be covered by insurance.

Probably more likely to be covered if you take the test kit to the lab or your doctor's office and have them do the finger poke, then submit the claim for you or you submit the claim with a letter from the doctor showing the doctor wants you to have the test.

I'd be surprised if insurance would cover 23andme, but you never know...

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

Posts: 4166 | From WA | Registered: Feb 2011  |  IP: Logged | Report this post to a Moderator
   

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