Researchers discover mechanism by which magnesium reduces cytokine production
Researchers at Case Western Reserve University School of Medicine recently discovered the mechanism by which magnesium reduces the production of cytokines.
Cytokines are molecules responsible for regulating inflammation; they play a key role conditions, such as diabetes, obesity, atherosclerosis, asthma, and alcoholic liver disease and cirrhosis.
Although the study related to pregnancy, inflammation is the culprit of many conditions and learning more about individual's magnesium levels may help a much broader patient population.
In a study published in The Journal of Immunology, the laboratories of Helene Bernstein, MD, PhD, and Andrea Romani, MD, PhD, reported
that magnesium decreases inflammation by reducing the activity of cells' primary protein, Nuclear Factor Kappa Beta (NF-kB), and the subsequent production of cytokines.
This new insight offers a promising new immunotherapeutic strategy by which a simple nutrient, known to be safe based on its extensive usage in obstetric settings,
can decrease inflammation in diseases other than pregnancy, including in other sepsis, respiratory distress syndrome, asthma, atherosclerosis, diabetes and cancer.
The cost of all of these diseases in the United States exceeds $200 billion annually.
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-------------------- 2 Corinthians 12:9-11
9 But he said to me, �My grace is sufficient for you, for my power is made perfect in weakness.� Therefore I will boast all the more gladly about my weaknesses, so that Christ�s power may rest on me. Posts: 1445 | From Poconos, PA | Registered: Jul 2004
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- Pocono,
Thanks for this fabulous post. Excellent find.
I'll add it to the set over here so it has more coverage, too:
posted
Ionic magnesium is supposed to be very absorbable. (like CALM)
I can't tolerate the CALM, so I take mg glycinate and use magnesium oil.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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Pocono Lyme
Frequent Contributor (1K+ posts)
Member # 5939
posted
Thanks Keebler!
CD57 IM probably would be good. I agree.
It looks as though no matter what form or kind, you do have to be careful as too much could affect your kidneys.
Lymetoo and others, what brand of magnesium oil would be good? I don't think I could fit any more pills in my organizer.
I use the word "organizer" loosely.
-------------------- 2 Corinthians 12:9-11
9 But he said to me, �My grace is sufficient for you, for my power is made perfect in weakness.� Therefore I will boast all the more gladly about my weaknesses, so that Christ�s power may rest on me. Posts: 1445 | From Poconos, PA | Registered: Jul 2004
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dbpei
Frequent Contributor (1K+ posts)
Member # 33574
posted
Here is some good information on magnesium from a LLMD who has Lyme Disease...
Which type of magnesium is the best to use depends upon why you are taking the magnesium.
1. GLYCINATE�Mag-Glycinate is the BEST for those looking to maximize absorption and bioavailability. Magnesium glycinate is ideal, as glycine is the smallest amino acid commonly found chelated to magnesium, and therefore highly absorbable.
Magnesium glycinate is absorbed intracellularly and has additional benefits due to the glycine to which it is bonded. When Magnesium crosses the blood-brain barrier it provides us with significant positive effects on our cognition, memory and brain health.
Magnesium L-Threonate [Magtein�]: can enter the brain. Magnesium blocks the NMDA receptor...this may be calming.
2. CITRATE� Mag-Citrate is absorbed pretty well but in high doses will cause bowel problems [diarrhea]. Citrate is also a substrate used for the beginning phase of the Krebs Cycle.
3.. SULFATE�Mag-sulfate is used to promote evacuation if you�re trying to clean out your bowels for a colonoscopy study.
4. OXIDE�Mag-oxide is OK, but not great. It is widely available in pharmacies but the oxide is generally worthless to the body. Magnesium absorption from the insoluble oxide and hydroxide salts (milk of magnesia) is erratic and of poor efficiency, since it depends on the neutralization and solution of the salt by the acid of the stomach, which is usually incomplete.
5. CHLORIDE�There are magnesium GELS that contain magnesium for absorption through the skin. These oily or gel supplements contain Magnesium Chloride for topical use but these seem to cause a lot of skin irritation in some people. �Ancient Minerals� magnesium oil is marketed for treating anxiety and to help with BP.
Magnesium in an Oil form is good for pain but may not be effective for replenishing magnesium at the cellular level.
6. MALATE�Magnesium Malate has been recommended for Fibromyalgia sufferers and appears to be adequately absorbed.
To replace magnesium for use at the cellular level use mag-glycinate.http://www.amazon.com/s/ref=pd_sl_4c5errh2r9_b?rh=i%3Aaps%2Ck%3Aancient+magnesium+oil&keywords=ancient+magnesium+oil&ie=UTF8&psrk=Ancient+Minerals+magnesium+oil
Some people take Epsom Salt Foot BATHS that contain magnesium for topical absorption via a bath. This may help avoid gut absorption problems which might lead to loose stools.
Caution still!! Magnesium absorbed from Epsom salts [Mag-sulfate salts] at high doses although being absorbed topically can still have a laxative effect.
Magnesium can also be administered via IV. This is common during delivery of babies in the hospital when the mother�s Blood Pressure is elevated.
A few natural sources of Magnesium from the DIET include: beansgreens nuts
To ABSORB magnesium from dietary sources we also need:Vitamin B6 Vitamin D Selenium
Posts: 2387 | From New England | Registered: Aug 2011
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- Shots do not have to sting IF B-12 is added in equal amounts. 1cc mag. sulf. and 1 cc of B-12.
When I first started magnesium shots the doctor (not a LLMD) did not tell me this and it was so painful, beyond words. Finally, I learned about adding the B-12. Takes the sting down about 90 percent. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Pocono Lyme
Frequent Contributor (1K+ posts)
Member # 5939
posted
That's interesting about the shots Keebler.
I'm so confused now. It looks like I could use more than one. Thanks dbpei. Good info..
I want the stearate for inflammation, L-Theonate to cross the BBB, Glycinate for absorbability.
Any suggestions? I can't do calcium with it as I run high normal in that already and at times have flagged high.
That put me on the hyperparathyroid trail but doesn't look like that is likely my problem. I was actually hoping it was.
-------------------- 2 Corinthians 12:9-11
9 But he said to me, �My grace is sufficient for you, for my power is made perfect in weakness.� Therefore I will boast all the more gladly about my weaknesses, so that Christ�s power may rest on me. Posts: 1445 | From Poconos, PA | Registered: Jul 2004
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