Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Beaches,
CBS mutations cause an "open gate" phenomenon in which all the stuff being sent through the methylation cycle drains out the bottom of the cycle instead of recycling back to the top of the methylation cycle.
In other words, CBS variants actually increase functionality of the CBS enzyme (unlike MTHFR variants, which decrease the function of the MTHFR enzyme).
But when an enzyme is sped up, it can make errors, pull nutrients away from other critical enzymes, and overload enzymes that deal with the outputs of the sped up enzyme (downstream enzymes of CBS include Molybdenum Cofactor, Xanthine Oxidase, Aldehyde Dehydrogenase, Sulfite Oxidase).
The ultimate result is increased ammonia, decreased tolerance for chemicals (sulfites, alcohol, perfumes, phenolics, etc.), and a consequent shut-down of methylation due to depletion of Vitamin B12 and necessary recycled methionine.
I don't have the answer on whether methyl-B12 is absorbed sublingually or orally. Dr. Yasko recommends oral/sublingual products that contain methyl-B12. But like you, I've heard methyl-B12 can't be absorbed that way. All I know is that I cannot seem to absorb any form of B12 orally or sublingually, so I have to get shots.
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4167 | From WA | Registered: Feb 2011
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Maya12
Frequent Contributor (1K+ posts)
Member # 36392
posted
Has anyone actually found that testing and treating the mutations has been helpful in recovery?
Posts: 1632 | From Canada | Registered: Feb 2012
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Vitamin B12 is essential to our very life. We cannot make red blood cells without it.
Glutathione (created by methylation) is also essential - our body depends on this for detox, even of metabolic byproducts of cellular function.
So IMHO, everyone needs to pay attention to methylation.
At the very least, people need to make sure they are getting sufficient Folate and B12, plus other B-Complex, Vitamin C, Vitamin D, and minerals. These are minimum requirements for our bodies to survive.
Specifically in my case, I am very much better off for taking B12 and Molybdenum (helps compensate for the CBS variant)... Basically, I am unable to tolerate much of anything at all (including water) without these two critical nutrients.
So in my case, yes, targeted nutrition designed to help with my methylation genomic variants has been enormously helpful (I'm convinced I would not be alive today without the B12).
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4167 | From WA | Registered: Feb 2011
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Catgirl
Frequent Contributor (5K+ posts)
Member # 31149
posted
Is it best to go off of supplements (already taking B-12) before I test, and if so, how many days prior to testing?
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
No, there is no need to stop supplements for the DetoxiGenomic, 23andme.com, or any of the Methylation genomic tests (MTHFR, or the whole Yasko DNA Methylation Panel). These are genetic tests, so supplements don't affect the results.
However, if you want to get a test to check B vitamin levels, you should avoid supplemental B vitamins for at least 3 days prior to the test.
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4167 | From WA | Registered: Feb 2011
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Catgirl
Frequent Contributor (5K+ posts)
Member # 31149
posted
Thanks Razzle!
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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posted
My LLMD told me that 90% of her Lyme patients have methylation issues, particularly with folic acid. She said that when I started taking the methylated folate 400 mg 2x a day, that I should notice a difference, and I did-I felt so much better quickly!
She said that I need to stay away from "enriched food" such as flour, where folic acid is added in, that with a methylation issue, that folic acid builds up and impedes the immune system, thus disease can reign.
I certainly felt a difference after just one day myself with methylated folate, and am planning to get the 23andMe testing $99, along with running it through Genetic Genie ($10 donation); there may be other nutrients that I'm not taking in properly that it will show me.
I need all the help I can get, and for that price, it sounds like a deal.
Posts: 123 | From Pawleys Island SC | Registered: Mar 2013
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