posted
Hi guys, I just wanted to share this article I came across on Pinterest explaining MTHFR mutations in relatively simple terms- I especially like the opening sentence:
"Just when you thought it couldn't get any worse with Lyme. Enter the MTHFR gene mutation, lovingly known as the motherf****r mutation in the Lyme world..."
I just found out I am heterzygous to both 677T/1298C and have submitted the 23andme test because my ND suspects I have more than the 2 major mutations. I have had some trouble understanding all of this but feel this article does a good job explaining the mutations, their health implications, and treatment options.
Posts: 428 | From Midwest | Registered: Dec 2012
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TNT
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posted
Thanks, danise,
I've been really thinking about this issue the last couple days and your bringing it up has made me study a little more.
I have the same mutation as you, daynise-heterzygous for 677T and 1298C.
Now, here's my question for those of you on lymenet who are more literate about methylation. I know Razzle is more knowledgeable, so maybe she can pipe in, too.
From what I found, for those that are homozygous for the 677t, the functioning of the MTHFR gene runs at about 10%.
If the 677t is heterzygous, then the MTHFR is running at about 70%.
But what about being heterzygous for both the 677T and the 1298C? What level of functioning does this equate to? Is it what it may seem- 70% ???
I understand that each of those two snps affect different things, but overall, would being heterzygous on both snps be less of an issue than homozygous for either one? Or is it more complex than that?
Some of the reason I ask is because I'm trying to figure out how much methylfolate I should be taking. And how much methylcobalamin. And how much methylfolate to methylcobalamin (ratio).
Any answers will be considered non-medical opinions. I don't want anyone to feel they are giving medical advice.
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TNT
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posted
Another question.
Has anyone had a reaction to nitrous oxide gas (for dental work) and later found out you were positive for mutations on MTHFR?
Posts: 1308 | From Eastern USA | Registered: Oct 2013
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-------------------- The fibromyalgia I've had for 32 years was an undiagnosed Lyme symptom.
"For I know the plans I have for you", declares the Lord, "plans to prosper you and not to harm you, plans to give you hope and a future". -Jeremiah 29:11 Posts: 6076 | From Pennsylvania, USA | Registered: Nov 2008
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nefferdun
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Thanks for posting that. The more ways it is explained the better I can understand it. She said " However, people with MTHFR have issues with absorbing or maintaining folic acid (they aren't sure), so they have low levels of it and their homocystine can get out of control."
Someone correct me if I am wrong but my understanding is Folic acid is artificial folate. People with MTHFR cannot convert it to methylfolate. If you eat a lot of fortified food or take supplements with folic acid, you can have a lot of it in your system. It will make it difficult for your body to "find" the folate from real food that you can actually use.
23&ME is the way to go. Someone recently posted sites where you can download the data from 23&ME to get your methlation cycle defects. The explanation on Promethias is really good - much better than what I got from Yasko. All of this for a fraction of the price too! So this makes this knowledge affordable to everyone.
After taking Yasko's Neurological Health Formulae for over a year, I put on two pairs of reading glasses to try to discover the extremely fine print of ingredients. I was shocked and horrified at what I found. It contains folic acid, cyanocobalimin and magnesium oxide! That is EXACTLY what we are warned to avoid!
One more thing, MTHFR is not EVERYTHING. I am only heterozygous but I still have major problems detoxing. That is because I have 15 out of 30 mutations and I am homozygous for 4 of them. I think my biggest problem is CBS, not MTHFR.
-------------------- old joke: idiopathic means the patient is pathological and the the doctor is an idiot Posts: 4676 | From western Montana | Registered: Apr 2009
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Catgirl
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posted
Great link Daynise. Yes 23&me gives us wonderful clues to what is going on. We all have something.
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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Razzle
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posted
TNT,
I'm not sure I can answer your question, but http://www.mthfr.net may contain the info for which you are looking...
I do think compound hetero for both MTHFR mutations is more complicated than having only one MTHFR mutation...
but I don't know enough about the MTHFR mutations to know what the effective functioning rate of the enzymes are for each of the different combinations of possible mutations...
Nefferdun,
I've got 11/31 mutations on the Yasko test panel, with 3 homozygous...and I agree with you, the CBS mutation is a way, way bigger deal than MTHFR for me too...
Yeah, I was also surprised to see that Yasko's supplements contained stuff she recommended we avoid...frustrating!
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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dbpei
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Member # 33574
posted
Thanks for these good articles! I have the same mutation as well - heterozygous for 677T and 1298C.
The funny thing is, I used to get nitrous oxide at the dentist and did really well with it. According to what I've read, that shouldn't have been the case.
I do have high homocysteine levels, unfortunately. I need to study up on all of this.
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Tincup
Honored Contributor (10K+ posts)
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posted
"Has anyone had a reaction to nitrous oxide gas (for dental work) and later found out you were positive for mutations on MTHFR?"
YES! I had severe and horrible reactions after going to the dentist, as well as after other surgery when the n.o. was used. Never knew why I was "weird". Now I know.
And doctors DON'T listen when you try to tell them about this situation. At least mine didn't, causing me some very BAD problems.
My reaction to the n.o. was the same as with some other meds that didn't work for me- instead they worked opposite of what they should have. The "laughing gas" made me super-severly depressed, and I couldn't get out from under the depression. I was suicidal and one time I'd say it was so bad I was homicidal also. Totally out-of-control.
To counter the affects- this is important to know and few know it- you use oxygen. Your fatty tissue absorbs the nitrous oxide and to get rid of it you need to "flood" yourself (your cells) with oxygen.
At one point, a week after the dentist giving me the "laughing gas" I blacked out driving down the road. All I remember was suddenly smelling the gas- like someone gave me a big wiff of it- then I was out like a light.
Luckily I ran off the road into a huge empty parking lot/field and woke up XX minutes later unharmed. That was really scary!
I now list it as an allergy due to the severe affects. I also wonder if this isn't some of the cause of post-partum depression that affects some women severely. ???
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