Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Berberine Chloride works in synergy with an efflux pump inhibitor.
"Determined to find a natural-product substrate, Lewis searched through the Merck Index for hydrophobic cations with no known activity. He stopped at berberine, an alkaloid made by Berberis, a
plant native to Colorado.
"We test it as an antimicrobial and it's lousy. Then we test it against a strain where we've knocked out the MDR pump and it's fantastic."
Working with phytochemists in Colorado, Lewis worked out that
Berberis fights bacteria not just with berberine,
but
also with 5'-methoxyhydnocarpin (MHC), a compound previously known only as a minor component of a traditional leprosy treatment.
MHC potently inhibits the MDR pump. Together, these compounds provide powerful antimicrobial protection.
Pump inhibitors are already in clinical trials but are thwarted by bacterial diversity. Pump inhibitors that work well against one species are often powerless against another, and clinicians rarely have time or means to identify the pathogen they're fighting.
But when they do, pump inhibitors could make nearly impotent antibiotics into wonder drugs once again."
Recent studies indicate that M. aquifolium contains a specific multidrug resistance pump inhibitor (MDR inhibitor) named 5'-methoxyhydnocarpin (5'-MHC) which works to decrease bacterial resistance to antibiotics and antibacterial agents. Wiki.
Amazon...both.
Yea Colorado!
BTW...the Oregon Grape is the state flower for Oregon.
Right "under our noses"!
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- As Oregon Grape contains berberine, would it be necessary to add even more then?
The kind of Berberine I use is from Barberry and has both the plant and the extract. I find it works better for me than just the extract that does not identify what plants are used. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Access to the chloride channels which are "open"?
Frontline, to protect our dogs from getting lyme impacts / blocks the chloride channels in the infected TICKS.
We can't block the same in us, but can make use of them...send in a Bb "poison" via those channels?
It appears to be cell specific - important. Targeted therapy.
Dosage and timing MATTER.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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