DO YOU HAVE THREE OR MORE OF THE FOLLOWING SYMPTOMS?
Lethargy / fatigue (especially upon waking)
Headaches or migraines with nausea
Yellowish tine to white of the eyes
Bruising very easily (capillary fragility)
Muscle ache, stiffness of joints, rheumatism worse in morning
White or yellow coated tongue, bad breath
Unclear skin, like acne or boils & some rashes
Intolerance to alcohol & chemical sensitivity (e.g. to perfumes), and other allergies developing as an adult
Fluid retention and/or congested lymph glands or sinuses
Dark circles under the eyes or puffiness around eyes
Excessive body fat and high LDL cholesterol, fatty liver and gall stones
Digestive complaints, such as bloating and fullness
Constipation - less than seven bowel motions a week
Poor concentration and memory, hyperactivity, Attention Deficit Disorder
Poor physical balance and fine motor skills, hand tremors (damage to cerebellum)
Tendency to negative thinking/feeling- moody – as in a hangover worse on waking
Posts: 6200 | From Brussels | Registered: Oct 2007
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Brussels
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THE VICIOUS CIRCLE OF CHRONIC TOXIC OVERLOAD
Look at the picture he drew:
Liver OVERLOAD is related to CANDIDA
Intestinal DYSBIOSIS
Joint, muscular, cardiovascular problems
Chronic fatigue
Many inflammatory conditions such as arthritis, cardiovascular problems, headaches, chronic fatigue, and premature ageing can all be caused and aggravated by a buildup of toxins that the liver is unable to cope with.
Read on to learn about the liver's detoxification process, and how proper nutrition and supplements can enhance this vital function.
INFECTIONS
Posts: 6200 | From Brussels | Registered: Oct 2007
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Keebler
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- Brussels,
Thanks for posting this excellent reminder on one of my favorite topics. Some articles here help explain more, such as "How the Liver Works" [with The One Earth Herbal Sourcebook link] etc.
LIVER & KIDNEY SUPPORT & and several HERXHEIMER support links, too. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Brussels
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BAD LIVER CAUSING CHEMICAL SENSITIVITY?
People with underactive Phase I liver detoxification will experience intolerance to perfumes and other environmental chemicals and are at an increased risk for liver disease.
CAFFEINE INTOLERANCE CAUSED BY BAD LIVER FUNCTION?
In addition, these people will experience caffeine intolerance, while those with an overactive system will be relatively unaffected by caffeine.
By the way cardamom spice raises the phase I enzyme that detoxifies caffeine, so adding some cardamom powder to teas or coffees is beneficial, especially if you are sensitive to caffeine.
(Brussels: I loved cardamon, and still do, I guess now I know one more reason why!!)
THE COFFEE TEST: One way of objectively determining a person's Phase I activity level is to measure how efficiently his or her body detoxifies caffeine.
This test has discovered that apparently healthy adults can have a five-fold difference in detoxification rates, and that this variability applies to most other toxins as well.
This is mostly genetically governed. People with a diminished capacity to detoxify are at greater risk of several toxin-induced illnesses.
Posts: 6200 | From Brussels | Registered: Oct 2007
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Brussels
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TOXIC CHEMICALS DISRUPT THE LIVER
Excessive amounts of toxic chemicals such as pesticides can disrupt the P-450 enzyme system by causing over-activity, or what is called "induction" of this pathway.
This results in high levels of damaging free radicals being produced as explained above.
Substances that may cause induction are CAFFEINE, ALSOHOL, dioxin, saturated fats, organophosphate pesticides, paint fumes, SULOFNAMIDES, exhaust fumes, HEAVY METALS and BARBITURATES.
SUCH TOXINS MAY LEAD TO INCREASE INFLAMMATION
The problem with these particular toxins is that too much activity may overload the body's stores of antioxidants and the Phase II system, which in turn may lead to INCREASED INFLAMMATION, liver damage and/or cancer rates.
HIGHER LIVER ENZYMES (HARMFUL)
The metabolites produced during Phase I are often potentially more harmful than their original toxic compounds, therefore it is important that they are not allowed to build up.
This is where Phase II detoxification comes in, if there are sufficient levels of Phase II enzymes to complete the enzymatic bio-transformation.
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WHY GLUTATHIONE IS ESSENTIAL FOR YOUR HEALTH
The Main Detoxification Enzyme: Glutathione
Glutathione also plays a fundamental role in numerous metabolic and biochemical reactions.
As the most powerful liver and brain detoxifier and protector, glutathione has multiple functions.
First, as THE MAJOR ANTIOXIDANT produced by the cells, it participates directly in the neutralization of free radicals.
It also maintains antioxidants such as vitamins C and E in forms that can be used by the body.
Through direct conjugation, it detoxifies many foreign chemical compounds and carcinogens, both organic and inorganic, and also heavy metals such as mercury, lead, and arsenic.
It is also critical for removing air pollutants such as volatile organic chemicals, and also many pesticides.
Every system in the body can be affected by the state of the glutathione system.
The IMMUNE system, the NERVOUS system, the GASTROINTESTINAL system, and the LUNGS are especially affected. ---------------
(Brussels: during lyme, we increase toxins in the body, due to herxes, for example.
Who does not have problems in these domains: nervous, immune, gastrointestinal and lungs?
During lyme I kept having breathing problems, despite having fought babesia successfully. Every time I herxed badly, my breathing would be affected too!
During lyme, my candida went bananas. My nervous system too. I gained more allergies, more sensitivities. It looks like my overcharged liver was the main cause!!!)
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WHAT CAN YOU DO TO IMPROVE YOUR LIVER?
Glutathione levels and the glucuronidation process are influenced by diet, as described below:
Milk thistle herb stimulates both glucuronidation and glutathione activity, and is the most commonly taken supplement for the liver.
Flavonoids from red grapes and blueberries help regenerate depleted glutathione levels.
Grape seed extract is an excellent supplement.
Selenium is crucial for recycling glutathione and is regarded as an anticancer nutrient as a result. It is highest in brazil nuts, but also found in wholegrain products – especially those organically grown
Whey powder is a good source of cysteine, the critical amino acid needed for glutathione production, and supplies most other sulphur containing amino acids such as taurine for the sulphation process.
Green tea encourages glucuronidation mechanism, as does Limonene oil, found in citrus peel, dill weed oil, and caraway oil.
Whey powder, eggs and cruciferous vegetables (e.g., broccoli, cabbage, brussels sprouts, cauliflower), and raw garlic, onions, leeks and shallots are all good sources of the natural sulphur compounds that enhance the Phase II detoxification reaction called sulphation.
Thus, these foods can be considered to have a cleansing effect.
Among foods, the Brassica or cabbage family (cabbage, broccoli, and brussels sprouts) contains chemical compounds that stimulate both Phase I and Phase II detoxification enzymes.
One such compound is indole-3-carbinol, which is also a powerful anti-cancer chemical.
It is a very active stimulant of detoxifying enzymes in the gut as well as the liver.
It potently neutralizes the carcinogenic activity of estrogens, and women who take brassicas regularly have significantly less breast cancer.
The net result is significant protection against several toxins, especially estrogenic carcinogens.
This helps explain why consuming these vegetables protects against several types of cancer, including bowel cancer.
Oranges and tangerines (but not grapefruits), as well as the seeds of caraway and dill contain limonene, a phytochemical that has been found to prevent and even treat cancer in animal models.
Limonene's protective effects are probably due to the fact that it is a strong inducer of both Phase I and Phase II detoxification enzymes and also helps to neutralize carcinogens.
Curcumin, the compound that gives turmeric its yellow color, is interesting because it inhibits Phase I while stimulating Phase II.
It is particularly effective in regenerating glutathione after it has been oxidized. This effect can be very useful in preventing certain types of cancer.
Curcumin has been found to inhibit carcinogens (such as benzopyrene, found in charcoal-grilled meat) from inducing cancer in several animal models.
It appears that curcumin exerts its anti-carcinogenic activity by lowering the activation of carcinogens through its anti-oxidant property while simultaneously increasing detoxification by improving the active form of glutathione (glutathione reductase).
Curcumin has also been shown to directly inhibit the growth of cancer cells, particularly lung and bowel cancer cells.
As most of the cancer-inducing chemicals in cigarette smoke are only carcinogenic during the period between activation by Phase I and final detoxification by Phase II, curcumin in can possibly help reduce the cancer-causing effects of tobacco.
Those exposed to smoke, aromatic hydrocarbons, and other environmental carcinogens will probably benefit from the frequent use of turmeric. (Note that curries usually have too little turmeric content to be effective).
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Brussels
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Are You a PATHOLOGICAL Detoxifier?
In some people, the two detoxification pathways are out of balance.
If Phase I is more active than Phase II, a build-up of reactive intermediate metabolites can occur, which in turn can lead to tissue damage and disease.
These people are referred to as pathological detoxifiers.
Pathological detoxifiers can be identified as those individuals who are highly sensitive to FUMES (e.g., paints and perfumes), react adversely to various PHARMACEUTICAL drugs, and may have a reaction to drinking CAFFIENE.
A liver detoxification test can pinpoint exactly how efficiently your liver is carrying out the detoxification process and determine if your symptoms arise from a phase imbalance.
Liver function can be evaluated with the Functional Liver Detoxification profile test available at IMI.
You can determine such things as the phase I: phase II ratio and levels of each of the main types of detoxification processes discussed above.
Correcting pathological detoxification or a lack of Phase II enzymes may reduce risks of cancer from both pollutants and hormones.
Pathological detoxifiers may also find it useful to include grapefruit juice, foods from the cabbage family, and curcumin-rich turmeric in their diets, as well as stopping coffee.
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How do I know if I have cirrohsis or a toxic liver? I am having nausea, dizziness, liver pain, and a feeling of high blood pressure anxiety .. Very scared
posted
I did the detoxigenomic liver blood test through Genova Diagnostics lab - it shows the body's ability to handle phase I and phase II of liver detox. Phase I is like the bathtub filling up, and phase II is like the bathtub draining. The test shows whether the phases are working or not, and whether they are too fast or too slow.
Then a more detailed test for the body's ability to detox via methylation can be done through www.23andme.com - they send a kit - it's a saliva spit test. Then we send the results to www.geneticgenie.org for interp. Or to the Tree of Life Ministries guy talked about here for interp and counseling re what supplements to take.
So in answer to your question, you would need to do some testing. I don't have knowledge of all the various liver tests you can do - just reporting on the two I have done and they are helpful in terms of providing knowledge about what is and isn't happening re proper liver function.
Just responding to symptoms you mentioned, for me, if my neck vertebrae are out of place, specifically C1 and C2, that can cause dizziness and nausea. A very good neck chiropractor could check that out for you.
You will need to sleuth your symptoms. Do you have any really good doctors you're working with?
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Brussels
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I guess, most of us fighting lyme and candida have a toxic liver. But you can make a test as suggested above, to confirm it.
Almost everybody here takes some supplements for the liver (like milk thistle)... I know that during lyme, my allergies sky-rocketed.
If I didn't take LOADS OF BINDERS, about 5 times a day (minimum), my life would have been miserable.
My progress of fighting lyme depended DIRECTLY on the amount of binders I took, liver and kidney supplements.
No binders = no improvement, in my case.
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Marnie
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AND kidneys AND lungs...these too are "detox" organs as is our skin.
Get a liver ultrasound done to see if you have a non-alcoholic "fatty liver". Your liver enzymes can be okay and you still can have a fatty liver.
It is not expensive, not painful. You have to fast before it is done.
Curcumin is great, but...it is not very "bioavailable"...get "Nano curcumin" (small particle size) or
a combination of curcumin + berberine HCL
(+ black pepper extract to increase the bioavailability of curcumin).
Swanson makes it. Available on Amazon. Not expensive.
SAM (as in SAMe for depression) et al is produced and consumed in the liver. Our liver has many functions besides "detox" and is capable of handling a fair amount of "insult" as well as regenerating very quickly when the "insult" is removed.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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Wow, what great info here. I have every single one of those symptoms except for the headaches. Awhile ago my ND wanted me to switch my liver support supplement and when I stopped the one I was currently taking I felt really awful. Lots of spaciness and chemical reacions/sensitivities.
I think I will up my dosage because I am not even taking close to the recommended daily dose. Maybe it will help me even more.
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Marnie
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What liver support supplement?
I'm curious which CYP enzyme might be involved.
Genetics impacts certain liver enzymes.
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