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» LymeNet Flash » Questions and Discussion » Medical Questions » Questions about 875mg amoxicillin twice a day

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Author Topic: Questions about 875mg amoxicillin twice a day
Xelaetaks
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1)If I haven't taken antibiotics in years what should I expect? You think it would cause dramatic effects or is amoxicillin a slow build kind of drug?

When I took it years ago I had no problems. I've taken a lot of anti parasites last year but I'm still sick and certain I have parasites but ready to try treating both parasite and lyme. Also have a lot of uncomfortable head symptoms. Literally feels like something living on the right upper side of it in a way but MRI's and other scans were fruitless so I haven't gone to a neurologist in around 6-10 months now.

I've been taking a lot of natural anti fungals and probiotics to preapare my gut for abx.

2)If it's twice a day does it need to be 12 hours apart exactly or is there any leway?

Also later in the protocol I will add tinidazole and albendazole to the mix, but amoxicillin starts first for two weeks.

Thanks

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SickSam
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That's such a small dose of amoxil, I wouldn't imagine you'd have problems tolerating it. I've taken up to 6000mg a day so far.

I was told to take two 875mg tablets twice a day (so 4 total each day) when I first tried amoxil.

For twice a day, the closer you can get to 12 hours apart the better, but it doesn't have to be perfect.

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Xelaetaks
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Thanks Sam. Glad to hear it's not such a big dose.
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sixgoofykids
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That's a very small dose for Lyme treatment, so you probably won't have a too terrible of a reaction. I took 2500 mg three times daily pluse Probenecid for Lyme treatment. Probenecid helps the concentration stay high in the bloodstream.

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TF
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I took 1500 mg 3 times per day plus probinecid. That is how I got rid of lyme disease (plus adding flagyl to these meds),


Without the probinecid, the amoxi is filtered out of your blood within 2 hours. So, I don't see how this protocol will work--unless you just forgot to tell us that you are also on probinecid.

Then, if you are, yes you need to come as close to every 12 hours as possible to have the maximum benefit.

On p. 18 of Burrascano, you will see that amoxi should be taken every 8 hours. Here's the quote:

"*Amoxicillin- Adults: 1g q8h plus probenecid 500mg q8h; doses up to 6 grams daily are
often needed"

(In plain English, 1 gram every 8 hours plus probenecid 500 mg every 8 hours. Doses up to 6 grams (6,000 mg) often needed.)

This is because of the short half-life of amoxi. The way you are taking it, you are going to have many hours during the day when you have no amoxi in your blood.

Half-life is the amount of time it takes for your body to get rid of half of the medication from your blood.

Half-life of amoxi: Half of each amoxi pill is gone from your blood in 1 hour. So, another half (of that remaining half) is gone the second hour. So, 3/4 of all of your amoxi when you take a pill is gone in 2 hours. Then, 7/8 the 3rd hour, etc.

This is what is happening without probenecid.

"The half-life of amoxicillin is 61.3 minutes"

http://www.rxlist.com/amoxicillin-drug/clinical-pharmacology.htm

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Xelaetaks
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Haven't heard about probinecid, but I can ask, assuming it isn't over the country. Also I'm surprised amoxicillin has such a short half life. Could it be cause of the other drugs she wants me to mix that it is such a low dose (Which include tinidazole, l-lysine and albendazole)?

She even wanted me to mix in fluconazole daily with the drugs but due to it's harshness on the liver I'm sticking with natural anti fungals for now.

Also I've treated for lyme in the past a couple years ago but now I'm retreating since it still shows up on multiple tests.

Thanks

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sixgoofykids
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I was on a whole bunch of other drugs along with the high dose.

The LLMD should do a blood test to see how much of the amoxy is in your blood. I forget the name of the test because it was so long ago for me, but that's how my LLMD came up with the proper dosing.

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TF
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I agree with sixgoofy. I took high dose amoxy with high dose flagyl (metronidazole). L-lysine and the other meds you named would not require a low dose of amoxy.

The fact is that this dose of amoxi is not going to do much. See this statement from Burrascano:

"Always check blood levels when using agents marked with an *, and adjust dose to
achieve a peak level above ten and a trough greater than three." (p.18)

This statement applies to amoxi. If your doctor was aware of the need to have a peak level above 10, you most likely would be on a lot more amoxi and you would have been given probinecid with it.

Best to ask your doctor to explain the dosage and lack of probinecid and carefully listen to the explanation. There could be a good reason for the dosage or there may not be.

These kinds of experiences help you evaluate your doctor's level of expertise or, learn what protocol your doctor believes in. Evidently, he/she doesn't believe in the Burrascano protocol.

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Xelaetaks
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Do you know any good llmds that work from out of state or near NJ that also treats parasites?

I'd be open to switching llmd's but I can't work with ones that know nothing about parasites bdesides the herbal protcols. I could also for the start of my protcol, use the amoxicillin 3 times a day if that sounds like a good plan?

Thanks

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tulips
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TF - for how long did you have to take Amox and the two other meds?
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TF
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Well, my entire story is that I was on amoxi (with probinecid) for 2 years with a lousy lyme doctor.

Then, I switched to a Burrascano type doctor. He said, "Congratulations. You have succeeded in turning all of your lyme into the cyst form." I said, "I know."

He then had me stop all meds for 1 week to make the lyme come out of cyst form. Then, he started me back up on the amoxi (with probinecid) and added flagyl.

On that combo, I got my first herx. I was finally on GOOD treatment.

I took amoxi for 30 days and flagyl for 60. After the first 30 days, he added Levaquin to kill bart.

Then, he moved on to treat babs.

So, as you can see, I had taken amoxi for 2 years. A complete waste of time. I don't know how that affected the amount of time my good lyme doc had to spend treating lyme.

All told, he treated me for lyme for 2 months. He later told me that he thought he would have to go back and retreat me for lyme after he treated bart and babs. But, that was unnecessary in my case.

I credit this to the fact that at the first appointment he told me that I MUST do the 1 continuous hour of weightlifting every other day (a full body workout) as required by Burrascano if I was ever to get well. I began doing it immediately. I had to work up to the 1 hour.

This weightlifting boosts the immune system and prevents a relapse when treatment is stopped. It is also believed to drive the meds deeper into the tissues to kill more germs and to oxygenate the body which lyme cannot tolerate.

It evidently worked so well for me that after treating babs and bart I didn't need anymore lyme treatment. I was completely symptom free! My body must have taken care of any remaining germs.

I had had lyme disease undiagnosed for at least 10 years before I got any treatment.

Just to be clear, I got 2 years of lousy treatment with just amoxi and probinecid. THEN, I got good treatment by switching doctors. Then, I treated lyme 2 more months and was finished with lyme.

Then, I treated coinfections.

All of this was completed over 11 years ago and I am still symptom-free, enjoying my life. That is why I believe in the Burrascano protocol. It got me and at least 5 of my personal friends well.

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TF
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X, amoxi alone, even 3 times per day, is going to be ineffective.

I can give you the name of a good lyme doc near D.C. He will require you to come in person once every 3 months.

I do not know if or how he treats parasite infections. If you want the name so you can inquire about that, let me know.

There are no good lyme doctors in NJ that I know of based on numerous patient reports to me over the last 11 years. So, I recommend that all patients in NJ come to this doc in Maryland.

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Xelaetaks
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TF I'm sending you a message. If I can find a doctor that has a shot at helping to treat me I don't mind traveling.

Thanks

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