My IgG subclass 1 results were 343 recently with 382 being normal and two years ago they were 356. What does it mean? My overworked local GP says it means nothing, it's fine and I can't get to my Lyme doc now. If anyone had similar results, it might be helpful to hear what your doc said. I am also Cytomegalovirus IgM positive and I have MRSA in my nose. Does this mean I probably have "subclass" deficiency?
A related question, as chronic Lymies do we count as immune compromised? I wonder this in relation to Covid. I have been very careful for 2 years but wonder if it's time to loosen up. However....
Thanks,
-------------------- Lyme, Babesia, 18 years Posts: 9 | From California | Registered: Mar 2022
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I also have CMV and have had MRSA in my sinuses. OH grand!!
I don't think we are considered immune compromised. I did very well through all of this. I took D3, zinc, selenium, etc the whole time.
I now have Covid antibodies and feel great!!
WELCOME!!
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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Bartenderbonnie
Frequent Contributor (1K+ posts)
Member # 49177
posted
Yes to both of your questions.
All chronic Lyme patients have dysfunctional immunity. The issue is the degree of provability based on current standards. To be diagnosed and approved for therapies, you must show a LACK of immune responses to the Pneumovax vaccine. The vaccine contains strep pneumonia strains that a healthy immune system will recognize and produce antibodies to.
You need an Immunologist, who will administer the vaccine, wait 3-4 weeks, and test your antibody immune responses. If IgG subclasses 1-4 are below threshold, you will be diagnosed with CVID (Common Varible Immune Disorder). You will then be approved for IVIG (donated antibodies) usually given every 3-4 weeks. Treatment longitivtiy based on yearly IgG levels.
ALL Lyme patients should be tested for an Immune panel. Total test levels of; IgG IgM IgA IgG Subclasses 1-4
CVID can be genetically predisposed or acquired. Many LLMD’s believe Lyme can cause acquired CVID.
Lyme patients who have CVID have poor responses to Lyme Western Blot testing. Also, Lyme patients that show a robust antibody response on the Lyme Western blot usually fare better during Lyme treatments.
This is because you NEED to be able to produce IgG antibodies against Borrelia to eliminate them. CVID Lyme patients will have a more severe illness and chronic resistant disease.
From Dr H; “Low IgG levels and subclasses may result in impairing ability to effectively treat Lyme and the associated bacterial infection.”
Other causes of adversely affected IgG’s; Mold Environmental Toxins Mycoplasma’s Bartonella Other Infections
“ALSO, the severity of clinical manifestations of illness is often explained by HLA status of the patient, including auto-immunity, persistent arthritis and the ability to remove toxins.”
You should get your HLA-B27 and HLA-DR4 markers tested.
posted
Thanks for your responses. I haven't been tested for either of the HLAs. I will get them tested when I get a proper doctor again. I was given the genetic tests that relate to the ability to remove toxins. I had the mold one and the one they call "the dreaded gene". I think that and the fact that I have Babs as well might be why I have had such a hard case.
I'll type in CVID too.
Thanks again,
-------------------- Lyme, Babesia, 18 years Posts: 9 | From California | Registered: Mar 2022
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