LymeNet Flash: Bb and my Cpn infection both MUST have DHFR

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Bb and my Cpn infection both MUST have DHFR

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Topic: Bb and my Cpn infection both MUST have DHFR

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

DHFR is absolutely required for Bb (and Cpn)to make its DNA. Bb can make its own folic acid and doesn’t need to get it from food we eat, but we do.

That enzyme is in the folic acid cycle and it ***uses NADPH *** to work. NADPH ***oxidase *** -> ROS which usually impacts most pathogens negatively and is how we clear many “germs”.

Bb down regulates NADPH OXIDASE by triggering mTOR - NFkB.
HBOT down regulates NFkB which reduces inflammation, big time.

But, we know Bb is protected from ROS via its use of MnSOD et al. H2O2 does not harm Bb either.

HBOT looks to raise NADPH.

DHFR impacts BH4 in the methylation cycle. We normally recycle BH4 which also impacts eNOS which I know Cpn down regulates for its own protection (endothelial nitric oxide synthase). We normally make glutathione via that methylation cycle!

Furthermore, looks like the drug methotrexate impacts that enzyme. It is given to treat RA…which my sis with Lyme (and me due to C.Pneumoniae) has/have as a result of our respective infections.

Does this equate to these infections causing us to be “undermethylated” which turns off our protective genes?

WOW…Google: “HBOT methylation” !!!

I tested positive for HLA-B27 which puts me at risk for “autoimmune”.

I dread the thought of that drug- methotrexate.

Brainstorming… methotrexate for MS - which is also strongly linked to Cpn in genetically susceptible person?

DHFR…dihydro…as also in dihydro Berberine = TWO HYDROGENS.

Food for thought for any chemists here! Please help.

[ 10-27-2025, 12:53 PM: Message edited by: Marnie ]

Posts: 9481 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

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