I have Celiac and Lyme.Lyme isn't the cause of true celiac disease, but can trigger the underlying genetic predisposition to celiac disease...bringing it to the fore...Celiac can also be present before lyme infection
Celiac is an hereditary auto immune disorder in which ingested gluten causes the immune sytem to create antibodies to the lining of the small intestine.
One can have the genetic predisposition and never develop Celiac disease. It is believed that Celiac is triggered by stress, trauma or infection. Some kids are born with full blown Celiac....Some of us don't develop it til much later in life. It's different for everyone.
What we do know is that 1 in 133 people have the genetic predisposition to Celiac...that doctors in the US are undereducated as to it's predominance and treatment...Doctors in Europe are very familiar with it...restauants offer gluten free items on their menus in some areas..We're just behind the wave in the US on this at present.
That so many people with lyme would have Celiac isn't that surprising given the odds of having the genetic predisposition.
I don't dispute the information given in the sited posts above about the gliadin molecule causing problems in permeability of the small intestine. But that does not necessarily mean that a patient has Celiac disease.
True Celiac Disease is not something that goes away but it can be treated by a life long gluten free diet, allowing the gut to heal and normal absorbtion of nutrients to resume.
Yes, the diet isn't fun, but it certainly is far from impossible. It stinks for someone like me who adores bread, ceral, etc...I'm still a major carb junkie, but the benefits of the diet far outwiegh the risks in my opinion.
For us I would assume that the key issue would be absorbtion of medication by the small intestine. That would depend on the amount of damage to the small intestine, and that can only be determined via edoscopy...eye balling the small intestine and taking a biopsy of the tissues.
The symptoms of celiac certainly fit on the list for lyme, so teasing out what is what seems impossible. I would think that determining whether one has genuine Celiac disease is important as well as determining the condition of the small intestine while treating lyme.
There are two theories on how the immune system damages the small intestine, one being that the culprits are NK cells. Some of us lymies have very low NK cell production. Perhaps lyme has a small advantage for us Celiacs after all!
I spoke with the head of Celiac research at UCLA children's hospital in June telling her of my lyme and low NK cell counts. She was very interested in talking with Dr. S in San Francisco about his NK cell findings, so I passed along her info to him. I don't know what if anything has come of that.
My endoscopy in May showed little or no damage to the small intestine, but my NK cell counts have been bottom of the barrel for several years. They did find an odd little gastric ulcer that looked more like a polyp...and has been blamed on high doxy use. Hooray! No more doxy for me!
My GI doc is trying to tease out how the Celiac and Lyme are interacting at this point, but there are no answers yet, just ideas. In the meantime, the gluten free diet is still the best way to go as the Celiac diagnosis for me is accurate. So is my lyme diagnosis...I'm just glad that my small intestine is in good enough shape to keep me on oral meds rather than going back to the IV route.