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» LymeNet Flash » Questions and Discussion » Medical Questions » Clinical study of Diflucan treatment for borrelia

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Author Topic: Clinical study of Diflucan treatment for borrelia
KH
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Saw this today on PubMed. Fluconazole is the drug we know as Diflucan, used to treat/prevent yeast.

I remember recently reading here on lymenet of a couple of people who say they really did not get better until they started addressing Candida problems, is this a coinsidence?

Clinical effects of fluconazole in patients with neuroborreliosis.

Schardt FW.

Betriebsarztliche Untersuchungsstelle, Bayerische Julius-Maximilians-Universitat, Klinikstr. 3, D-97070 Wurzburg, Germany. [email protected]

Eleven patients with neuro-borreliosis had been treated with 200 mg fluconazole daily for 25 days after an unsuccessful therapy with antibiotics. At the end of treatment eight patients had no borreliosis symptoms and remained free of relapse in a follow-up examination one year later. In the remaining four patients, symptoms were considerably improved. At the end of therapy immune reactivity (IgM+) disappeared in three patients. Since borrelia spp. are almost exclusively localised intracellular, they may depend on certain metabolites of their eucaryotic host cell. Inhibition of P450 and other cytochromes by fluconazole may incapacitate Borrelia upon longterm exposure.


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minoucat
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Hmm. I don't know anything about the chemical attributes, but it's interesting that Flagyl and Tinidazole, also antifungals, can also be effective in treating Bb. Be interesting to know if the Diflucan was specifically effective against the cyst form.
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dontlikeliver
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That is very interesting. But, I think if this is the case I would have been cured long ago.

I was on Diflucan for 4 months 10 years ago and still ill. Then again for 30 days in March/April this year and not cured by that.

Maybe it only works for some.

DLL


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TheCrimeOfLyme
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Flagyl is also a P450 inhibitor. Interesting.


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riversinger
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From this abstract it's really hard to tell what actually happened. We don't know what kind of antibiotic treatment was used, and for how long. Whether these were recent infections, or chronic.

As far as outcomes, three people no longer had positive IgMs. But we all know how much THAT means. There is no indication as to the IgG response.

There is also a lot of room for wiggling when they say there were no symptoms. It all depends on what where considered symptoms. Since they are talking about Neuroborrelliosis did they include arthritic or other symptoms as criteria?

It's possible that the full article contains some of this information, but based on the abstract, it's impossible to evaluate the relevance.

I was on Sporanox (another azole) full time for over six months, and didn't get cured, though it made a big impact in symptoms from my mold infections.

It's been antibiotics that are making the biggest difference.


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beachcomber
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Interesting but, it seems to me that the Diflucan is really hitting the Candida symptoms (that mimic Lyme) that tend to be worse when one goes of abx. I was on Diflucan for 5 months with no significant clearing of Lyme sypmtoms & still tested positive for Lyme and Systemic Candida. The Candida blood test is similar to the Lyme test, in that it measure IgG, IgM and IgA. You can be free of Lyme and still show high antibody levels while your immune system is rebuilding. The Candida can hang around a lot longer & is often mistaken for Lyme. Just MO, but I think the Diflucan is hitting the Candida, thus helping the immune system to recover as it dies off and the normal flora balance returns.

If it's not one thing, it's another.


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circuspeanut
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I thought I'd report back on my experience with Diflucan so far.

I gave my doc the above study and we figured it can't hurt to try it. I've been taking 200mg nightly with my vantin (abx) and flagyl for 4 weeks now.

I have to say, I am feeling MUCH MUCH better. I had terrible thrush when I first started the abx, but that cleared up very rapidly with the Diflucan.

So, for what it's worth, I think the Diflucan has really helped me. I feel much better than before I started the Lyme treatment in August, particularly in terms of brain fog. It may be in conjunction with the flagyl and vantin, or not.

I'm drinking tons of water to help reduce the load on my liver. (I need to start a thread and ask what kinds of supplements have worked for folks to help detox the liver/bladder/spleen, just in case.)

So far, so good.

peanut


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KH
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That is very interesting news.

Through out my treatment which started in March '04 I have not been taking any diflucan, but have started taking maybe 3 a week, at 100 mg each time. Have not noticed too much difference, but have noticed that I've been less dizzy in the head.


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circuspeanut
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KH,

At that smaller dose, you might want to try it daily for a week or two. I think it's one of those meds that's better when you keep the blood concentration even - you have to build up & keep a steady amount.

Let me know if you try it!

peanut


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KH
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Circuspeanut,

I am considering taking diflucan for a month straight, but wanted to do some more research before starting. I remembered a heath news item a month or so ago regarding erithroymcin (sp?) which is I think biaxin, that can cause heart attacks if taking certain drugs, and diflucan was one of them. Since I am on zithromax, which is also a macrolide and similar to biaxin, I am worried about taking both together.

I noticed you are on something else. I have never heard of, vantin. What is that?

You you know or anyone else the science behind the p450 cytochromes and enzyme/protein relationship? May this have something to do with how borrelia survives is us?


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