I am also constantly getting the feeling like I am about to just slump down on the floor by the toilet (i.e. like I'm about to be violently ill or just have been - but, in reality, I haven't). I have had on/off queasyness/nausea. My breathing is kind of fast and shallow also. I do not feel anxious (other than now starting to worry what these unfamiliar sx are).

My legs feel very weak, and sometimes when I walk I have to will them to go how I want and not buckle - like I have to concentrate on walking.

My breathing seems fast and shallow also and am getting heart skip feeling now and then.

I have also had for several days a pressure like headache also in my neck and around upper spine. (THIS symptoms I HAVE had before).

I feel as though this is something new and like it's going out of control. I can't even put my finger on it completely, just feel weak and ill to the core. Like I'm about to die.

Have never had this over-all abdominal quivering before.

I even feel weak lying in bed.

When I read this, it sounds like nothing extraordinary, I know. But, in reality it feels scary and unfamiliar and I guess now my thoughts turn more sinister like am I getting some rare illness from taking Mepron and Biaxin.

Does this sound like anything? Would a herx be suddenly worse than anytime before, and so different to "normal" symptoms - even 3 months into treatment (for Babesia).

I don't feel scared when my "normal" symptoms are worse - I just see that as herx. But, because this is different and feels like I have no control, or like it's taking over, I am scared.

I don't feel flu-like or viral, perhaps that is what is scaring me because that is my usual problem, and when herxing that is worse.

Tongue seems same as usual
Breathign a little shallow and fast
Temp OK
White of eyes OK
don't know BP.

I am not in the US now, but due to travel in 3 weeks. I am worried it will be a nightmare trip if I don't get a bit of strength soon.

I will check Mepron buddies thread a bit later, right now doing only about 2 mins at computer at a time.

So strange I should read this today as last night I had the same exact thing going on.

I've never carried a pregnancy to term but I imagine it's similar to being kicked by the baby, at least that is what I have been feeling. Last night it was in my lower abdomen and left calf, today it's in my back beneath the left shoulder blade.

It's like a pulsating of sorts, only more fierce that just twitching. Does this sound like your experience?

I know for me, when something new happens I think that subconsciously I panic and that causes shallow breathing....I call it silent anxiety and it's very understandable, though maybe not the same in your case.

I have had a little nausea lately but nothing specific to speak of. Ironically, I did have perhaps a touch of food poisoning Saturday morning but one painful episode in the bathroom seemed to take care of it. I don't know if the two are related or not, as I'm still feeling this today.

I'm thinking it could just be Bb neurological symptoms, maybe our muscles contracting for whatever reason........at least I'm hoping this is it. I'm one of the "Morgellon's sufferers" so I hate thinking the alternative, if you know what I mean.

It really is disturbing when something new comes along that we haven't experienced before. You hate to be a worry-wart yet you don't want to attribute everything that happens to Lyme, either.

I love liver. Ok anyway I experience what you describe every day, pulse skips, heart racing, extreme weakness, nausea, heartburn, pain, movement, weird stomach stuff, legs dont work unless i force them to, even weak when in bed, and yes yes yes it feels like death.

Its not a herx for me since i havent had much meds if any. Its just lyme and probably a coinfection I havent been tested or treated for. You are being treated so this could be a herx, if so yippy you really are lucky, although it truely is a nightmare to go through and Im so sorry for your suffering, this disease can be just plain horrific.

Keep at the meds, keep in touch with your doc on your symptoms, and truely best of wishes for a genuine full recovery.

this nerve, the vagus nerve affects the breathing, pulse rate, etc..and when it's affected you get weak etc...

not sure, but i get this, and I get so i feel like I have pressure from my middle section adn then pressure in my head and sometimes feel like i'm going to faint or something..

for me it passes when i go to the bathroom...

I don't like it either.

I just have just been waiting it out and appreciating those moments when it lets up.

I do wonder if Mepron has something to do with it but not quite sure. It has been hit and miss with me on the Mepron because I am not sure if the symptoms are connect to it or not.

I just know i don't like it and want it to go away. I also know it will go away. This too shall pass.

I am on Mepron and Rocephin. I did OK with Rocephin. It seemed like it was when the Mepron was added...but not too sure...other things to factor in too.

I ended up in the ER more times than I want to think about because I couldn't stand up and my heart was so goofy. They kept calling it nerves and would give me a shot of compazine and send me home.

The only foods that seemed to settle well tended to be sweeter things with little protein, and I think that probably added hypoglycemia to allt he other symptoms.

Finally a friend of mine said he'd had the same thing for months and it seemed to get worse when he ate meat. Like me, all his blood tests were normal, no fever, etc. One night it got really bad, they ER sent home home with a "case of the flu" and his appendix ruptured. He almost died of peritonitis and told me to be sure and find out if my appendix was starting to go bad.

So I had GI series and more blood tests and everything looked okay (still no pain in my right side) but I was so sick I could hardly function. I finally found saw a surgeon whose wife had been through the same thing and it was a condition he called "appendicile colic" which meant the appendix wouldn't empty properly and bacteria would build up, then it would get dumped into the system. High protein foods made it worse.

So he took out my appendix which he said was kinked and inflamed and would have ruptured before much longer and the mysterious symptoms went away.

You're probably going to say you had your appendix out already :-) But even if you have, I'd suspect something strange going on in the digestive tract that's causing some toxins to be released.

Could be couple things, 1 hypoglcemia. Causes those type synptoms. Which very easily could be part of lyme co-infection.Poss. med. or vit. herbal interaction????

I also have fm/mps/ebv. They may be linked to lyme or a co-infection of.

A doc in Ind. is taking the topic of fm to legilation for us to finally try to get doc`s med profession to take seriously.

He did not mention lyme but found fmers. Who duffer a multirude of symptoms, close to lyme or ms.

He has found aleas 17 diff. viruses, which makes it even harder to treat or cure.

Each 1 has to be treated seperately 1 by 1.

This is hard to get the right doc for & right treatment also most tests do not include these viruses.

You very well may cave advanced to another virus. Poss. through mutating incorrect tratment for lyme co-infect. No 1 knows for sure.
That is why some respond to some treatments others do not because correct testing has not been done, even so it is all guess work as lyme is/ Especially since all 6 lymies I keeo in touch with are on diff protocol.

Things you have mentoined know what you are trying to say after I got bit by mosquito.not tick this time. Became quite ill,encephalitis they believed, poss WNV.
Past yr. now have alot of diff. symptoms. SOmetimes sorta scary since thought I just was able to tell what flare I was in, meaning which virus was acting up at the time.

Now constant state of nausea, diff than the gerd, besides for some of the other symptoms you have mentioned that are hard to put into words.
I am not able to be treated for lyme,still working on what dorection.
do understand the toilet issue with nausea, this is almost constant.
I have read been told erichliosis can act like this. So can many of the 17 viruses with fm this doc has been researching for yrs.

As I am not feeling quite as bad this morning, but not out of the woods, I am feeling less scared and I do think that what Ila2 has said in this case, is probably what is going on.

A herx affecting the vaso-vagal nerve. I had a fever again last night with it also and horrible extra-sweaty nightsweats.

The quivering intestines bit for me did not at all feel like a baby kicking (I would describe the baby kick more like a gas bubble or twitch). The quivering is more a feeling like my entire length of intestines "shaking" or shrivelling up.

I am still off my food (Is that normal with a herx?).

I really have no wisdom to offer, just support.

Since my illness began, I've had several bouts of fasciculations in my mid-to-lower abdominal muscles. These had no effect on my digestive processes -- they were just intense flutters that got my attention by being so odd.

I just finished a 30-day course of Rifampin (with nothing else) and my liver got so torqued up that my normally cast-iron stomach got queasy several times. Milk thistle has been helping that. Might your liver be stressed?

I hope you feel better soon and get some answers!

Sorry your struggling with weird new symptoms.

My reply is much too long and have to warn you it is full of speculation.

I know exactly what you mean about a new symptom that is some kind of red flag. You just know that something is not quite right. All of us listen to our bodies.

I took 2 bottles of Mepron. The first bottle was pretty easy to take. The second a little tougher. I stopped and started a 3rd bottle many times, but it was beginning to cause new neuritis diagnosed by my LLMD of right lower leg/bone pain from below knee to top of foot.

Anyway, I just woke up with this severe bone pain. Believe me, I know pain quite well.

This was scary and different. Something was very wrong. I stopped my Mepron or I could not have traveled to Houston to see my LLMD. I wouldn't have made it.

It also began to trigger all my old pain sites in my head: left ear pain, forehead and back of head pain (meningitis type pain).

It was crying pain of the head and I had a complete meltdown------just so sick of the pain. And suddenly it was back. I told my husband there was no way I could make it to Houston in this shape. It was a very bad scene.

Mepron made me brain dead by the time I stopped taking it and caused some confusion a few times which freaked out my husband.

My LLMD told me to stop the Mepron as it can cause new neuritis. He told me Mepron goes to the brain. I had also told him I was Mean Mepron Mommy and basically brain dead trying to get down the 3rd bottle.

I have scanned the Physician's Desk Reference on Mepron. It does list insomnia as a side effect of the med which would indicate it goes to the nerves. No where does it say it crosses the blood brain barrier.

I called GlaxoSmith Kline at 1-888-825-5249 just now. I asked if Mepron passes the BBB.
The pharmacist had to stop & look this up herself.

She said this reading from insert:
Under heading of DISTRIBUTION: children receiving 750 mg 4 times daily for 2 weeks only had cerebrospinal fluid concentrations representing less than 1% of the plasma concentration.

This pharmacist said less than 1% in the CSF was not clinically relevant.

All I can figure out is that I was building up toxic levels in my bloodstream. Either I'm a slow metabolizer or my liver cannot metabolize Mepron out of the body as fast as it should be eliminated.

I just paid $25 for my medical records and they forgot to include the August Lab work. I wanted to see if anything was abnormal such as liver, kidney or pancreas------can't do that yet. (LLMD's practice is closed.)

The only thing I can speculate is because Mepron has a very long half-life, it has greater chance of toxicity in some patients.

Mepron half-life is 67.0 +/- 33.4 hours to 77.6 +/-23.1 hours.

From drug insert: It states the long half-life is due to presumed enterohepatic cycling.

It also states: "It is necessary to treat patients with severe hepatic impairment, caution is advised and administration should be closely monitored."

Years ago, my pain doctor told me it can sometimes take a long time for liver problems to show up on Liver Function Studies.

But in my amateur opinion, I would imagine it could show up rather quickly on a drug induced liver problem.

Some of the side effects reported during post-approval use of Mepron:
Pancreatitis and acute renal impairment.

If you happen to scan the PDR information, most of the research was primarily done on AIDS patients so while it's very helpful, to me the research is slightly skewed.

Here is the link which is in the PDR information or drug insert info Mepron:

http://www.drugs.com/PDR/Mepron_Suspension.html

As for me, my shortness of breath is gone and the red pin points (petechiae) on my upper body are fading, but not gone.

I probably do need more Mepron as I've had undiagnosed LD for 13+ years. First, I would need to detox my liver. I am not afraid to try Mepro again. As I said earlier, the first bottle is tolerable.

If you can scan that information, you will see Mepron can cause fever, asthenia (profound weakness), fever, abdominal pain, headache and of course, nausea, insomnia, itching (pruritus).

It caused me a weird depression-----can't explain it, but it's not listed as a side effect. Also, it killed my appetite----just gone.

I'm not even certain as to what happened with me on Mepron. So please realize this was my experience only. The rest is simply my opinion.

As Cave said the real experts are on the Mepron Buddies Redux thread and I think they've started a newer one, also.

Those who can stay on Mepron for months at a time (with a break between bottles) must be fast metabolizers or have really good livers.
But that's strictly me speculating.

I hope you and your doctor can figure out what's going on. Just because I became toxic on Mepron does not mean that you're toxic on Mepron.

That's the million dollar question with every med. Is it a herx, toxicity or allergic reaction?

I would definitely call my doctor, maybe he could let you lower dose or stop for 1 or 2 days.

But then again, the drug resistance problems is always a question, so that definitely would be something your LLMD would have to answer.

I'm sure you'll be fine and you'll find the answers, but keep listening to your body.

Take Care,
Jan

Do you have your appendix?

Please be sure to rule this out.

With fever, and other symptoms, I am concerned. My son just had this, and an important piece in ruling it in or out is to note that antibiotics will DAMPEN the usual symptoms and signs of appendicitus, but not lower the seriousness of the infection (they also will not adress it)

ER's will normally check WBC count, and maybe do a CAT scan..however it is also important to note that BOTH of those results will also be effected by abx.

WBC count may not rise to the usual range in those not on abx, and the CAT scan is often equivocal.

I would think you might should call Doc B on this one.

If they do want to evaluate, it would be good for him to stress to the PCP or ER that the normal "signals" will be subdued..

Certainly, that may not be it..but..I would chack it out.

All the best,

Mo

The stomach quivering has stopped. I do have my appendix still, but I would say this quivering feeling I had spared my appendix area anyway.

I do not have any stomach ache(s) now.

I am still feeling weak, and swaeting quite a bit, feel overheated and have a low-grade temp.

I have been feeling achy, esp. across my upper back and neck, and pressure headache for over a week now.

My BM's are a bit stinkier than usual (yuk).

I just feel sick, basically.

I now have, and probably unrelated to all this, a stinging (kind of) on/off pain and heat sensation on/in what I guess is my breastbone (front, top of ribcage below collar-bone).

Just looked up (Iknow I should not have) burning, stinging pain in breastbone and google throws up Lymphocytic Leukemia. Help.

Can taking the abx and Mepron cause this. How likely is it. I am flipping out now.