posted
I'm wondering if the vitamin E in fish oil will interfere with the artemisinin. Each fish oil cap has 3 g Vit E and I have been taking two caps at the same time as my art.
I'm wondering what else has antioxidants. I know of co-Q10, but I'm not sure what else qualifies.
Posts: 134 | From So. California | Registered: Sep 2004
| IP: Logged |
posted
up...please
Posts: 134 | From So. California | Registered: Sep 2004
| IP: Logged |
charlie
Frequent Contributor (1K+ posts)
Member # 25
posted
....I don't know about fish oil but the allergy research artemesinin bottles say 'combining with antioxidants or iron may theoretically decrease effectiveness'.
posted
"The biological activity of artemisinin, arthemether, and their joint metabolite, dihydro-artemsinin is ascribed to the liberation of free radicals (active oxygen) that results in the destruction of the endoperoxide bridge."
Expert Rv Anti-infect Ther 2(2) 181-196 (2004)
The implications of this for taking supplemental antioxidants during artemisinin tx are none too clear to me. It seems obvious that there is some antagonism, but I dont know how to guess how significant it might be, or whether its significance outweighs the benefits of antioxidants to the host anti-babs response(s). To do biochemistry, one needs some rough quantities at least.
You can see read several peoples views in the archives: keywords artemisinin and antioxidants should get you somewhere.
Personally, I have so far been consuming minimal antioxidants (no supplements, just regular good diet) during my babs treatment, but that is partly conditioned by the fact that I am hoping the treatment will be only a month or so long. My decision aint exactly science. But like Charlie says, what little info I have is good enough for me.
Vit C is also an antioxidant, and a complete list of antioxidants can probbaly be found with google.
bpeck
Frequent Contributor (1K+ posts)
Member # 3235
posted
The DRUG derivation of artemis kills by H2O2 burst, and the creation of free radicals.. so you would not want to use antioxidants while on this treatment (this treatment is only 5 days long and the drug artemos worked for me to erradicate Babs). You also need to restrict consumption of iron for 5 days (which is extrememly hard cuz it's in everything).
I have never satifcatority gotten an answer from the supplement companies about the artisiminin SUPPLEMENTs on the market today..i.e. how much is in the capsule- and do they create an oxygen free radical??? Or hydrogen peroxide (H2O2)?? If so, then I wouldn't think long term this would be a good thing... i.e. constant low level of free radicals is corrosive to all cells.
Almost all the antioxidants neutralize a free radical-- so you'd be wasting your money if you took these substances together.
If the supplement does create free radicals, and this is your aim, then antioxidants should be withheld while taking it, then resumed when you stop the artesiminin.
Barb
Barb PS.. if any one knows if these supplements create oxygen free radicals in the body, I'd like to see their reference..thanks.
[This message has been edited by bpeck (edited 05 January 2005).]
posted
> PS.. if any one knows if these > supplements create oxygen free > radicals in the body, I'd like > to see their reference..thanks.
Barb, according to Expert Rv Anti-infect Ther 2(2) 181-196 (2004) (PMID 15482185):
"The in vitro activity of artemther is only slightly superior to that of artemisnin, the main clinical-parasitological effect in both cases being exerted by [the human metabolite] dihydroartemisinin. [no citation]"
"The blood schizontocidal activites of artemisinin and dihydroartemsinin show a highly significant correlation, the metabolite being approximately ten-times as effective as the parent drug at the median effective concnetration (EC50). At the EC90 and the EC99 the phenomenon was even more marked. [citation: Mitteilungen der Oesterreichen Gesellchaft fuer Tropenmedizin und Parsitologie 22, 87-93 (2000)]"
"The antiplasmodial [antimalarial] activity of artemether and dihydroartemisinin is caused by the release of free radicals. [no citation]"
The quality of this paper is pretty good, in my amateur opinion. It seems well-detailed.
On web pages I have seen other antimicrobial actions mentioned as "possible" for artemisinin and related molecules, but I have never seen a ref.
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic