Will check B1 and Nerv. Syst.

The structure of the 60 kDa PYROPHOSPHATE (PP(i))-dependent phosphofructokinase (PFK) from Borrelia burgdorferi...
PMID: 12015149

"Vitamin B.1 (Thiamin) functions as the cofactor for an important biocatalyst called pyrophosphate (remember Valletta's patent/) .

This catalyst is involved in phosphate metabolism in our cells and performs a vital part of optimizing the energy availability to our cardiovascular cells.

Thiamine, the first B vitamin to be identified chemically (1926), consists of a complex organic molecule containing a pyrimidine and a thiazole nucleus. In the body it functions as a COENZYME in the form of thiamine pyrophosphate and is important in carbohydrate intermediary metabolism.

The symptoms of thiamine deficiency are known as BERIBERI, a syndrome consisting primarily of peripheral neuritis marked by sensory and motor paralysis of the limbs and, finally, heart failure.

Vitamin B1 or thiamine, combines with phosphorus to form thiamin pyrophosphate necessary for the metabolism of protein, carbohydrate, and fat. It is essential for growth, normal appetite, digestion, and healthy nerves. Vitamin B1 may prevent, correct or help aging and memory loss.

Magnesium is necessary for the conversion of thiamine to its biologically active form, thiamine pyrophosphate.

Some cell types have H+ pumps which are driven by pyrophosphate.

Magnesium ions are required for pyrophosphate release. In fact, none of the partial reactions specified in Fig. 1 can be observed in the absence of magnesium ions.

Thiamin Pyrophosphate, it is crucial in several metabolic functions including the removal of Carbon Dioxide, and the Decarboxylation of Alpha-Keto Acids.

Thiamin works synergistically with other members of the B Complex particularly Riboflavin (Vitamin B-2) and Niacin.

As part of an enzyme, thiamin pyrophosphate, is essential for energy production, carbohydrate metabolism and nerve cell function.

Marnie,
Thanks I was also considering allithiamine, a fat-sol. form of B1. Checking into this, just out of curiosity.

Will check the pmid