I am on Doxy, and have researched it a lot.
I have never heard anyone go that high a dosage, but maybe others have.

Not sure if you have done Minocycline, but some say it has better tissue penatration and stronger then Doxy, so maybe this is better for you, the mino and therefore you would not have to go so high dose with the Doxy.

I can see how your Dr would be uncomfortable with this dosage, I have heard it is not the best drug to be on long term, not sure if you are on it long term.
I read on here some have stayed on it long term though, say about one year.
I was told that Doxy and mino can sometimes cause a permanent purple skin discolouration taken long term. I heard this from one of my Dr's. I looked this up on the net and did find that some sites said this can happen.

I have been on it for about 5 months, the Doxy, and am on 300mgs a day, any higher and would be dead after a couple of weeks, too much herxing. I have had lyme about 16 years or so, so I have to go slow with the antibiotics most times.

It will be interesting to see if others have heard this dosage you are doing. I read Dr B's guidlines and he uses the high dose as 600 mgs.

I know most Docs don't do this, and I really do not understand why not.

There's a fine line between efficacy and toxicity, and I realize we walk that line.. but doses that are extremely high will leave collateral damage in the body...(ask your liver/kidney and biliary system - which has to metabolize those drugs).

My doc is adamant about doing monthly blood tests, to make sure that no damage is being done to liver/kidneys/biliary.

I have seen one article from a LLMD that says that doxy, at doses of 300-700mg do cross the blood-brain barrier, I'd like to find others that talk about doses that high.

I think I may metabolize the doxy faster than most and maybe that's why it's taking so much to make the difference in my symptoms. We're being careful. I bought a really 'cool' hat today, since I work outside about 1/2 of the time and I use
spf 45 sunblock on any exposed skin.

Thanks for any other info. on published protocols or any info. on docs that have gone this high!

Coyote, please edit your original post to 6-8 lines of text only. For us late stage lymies, we need to break things up a lot so we can comprehend. Thanks for helping us all out.

I herxed like mad for a while and then nothing...

I always got the feeling the doxy couldn't reach my brain..

Is it suppose to cross the bbb? I donno...

I have been told that Doxy is hard on the body, the liver and kidneys, so this high dosage may not be a good idea.

I would def make sure you know what you are doing... because if you damage your organs early, HOW will you do the long term antibiotics, which in your case may be 6 months to one year only?

Ask your MD to call Dr B perhaps and see what he says. There may be a good reason why he does not go or say higher then 800mgs.

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Originally posted by Coyotecrazy:

My doc is adamant about doing monthly blood tests, to make sure that no damage is being done to liver/kidneys/biliary.

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