BartonellaCat-Scratch Disease
Cat-scratch disease is an infection at the site of a cat scratch caused by the bacterium Bartonella henselae.
After a person is scratched by a cat infected with Bartonella henselae, the bacteria tend to infect the walls of the blood vessels. The cat usually shows no signs of illness.
Symptoms
Within 3 to 10 days of getting a minor scratch, the person usually develops a red, crusted blister up to 21/2 inches in diameter. Rarely, a blister containing pus (pustule) appears.
Lymph nodes in the area swell, become firm, and are tender when touched. Later, they fill with pus and may drain through the skin. The person may feel ill, have a lack of appetite, and have a fever or headache. About 10 percent of the infected people have other symptoms, such as eye problems, which cause visual changes, or brain swelling, which causes a headache or stupor.
In almost all infected people, the skin clears up and the swelling in the lymph nodes disappears within 2 to 5 months. Recovery is complete. A severe form of cat-scratch disease can occur in people with AIDS.
Diagnosis and Treatment
The diagnosis of cat-scratch disease seems likely if a person has swollen lymph nodes for more than 3 weeks after being scratched by a cat. In uncertain cases, a blood sample may be tested for antibodies to Bartonella henselae.
Treatment consists of applying heat and taking pain relievers. A fluid-filled lymph node that is painful can usually be drained with a needle to alleviate the pain. Antibiotics may be given to help eradicate the bacteria, especially in people with AIDS.
http://www.merck.com/pubs/mmanual_home/sec17/177.htm
Lupin Ap4A hydrolase has particularly high sequence identity with the Ap4A hydrolase encoded by ialA, one of two genes associated with the ability of Bartonella bacilliformis to invade and survive as a parasite of human erythrocytes [4].
Lupin Ap4A hydrolase is also a magnesium-dependent enzyme.
http://www.biochemj.org/bj/357/0399/bj3570399.htm