LymeNet Flash: P450 Drug interactions with Lexapro/SSRI's

LymeNet on Facebook

LymeNet on Twitter

Follow @LymeDiseaseNet

The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive

The Lyme Disease Network is a non-profit organization funded by individual donations.

»	LymeNet Flash » Questions and Discussion » Medical Questions » P450 Drug interactions with Lexapro/SSRI's

UBBFriend: Email this page to someone!

Author

Topic: P450 Drug interactions with Lexapro/SSRI's

auntybiotic1499
LymeNet Contributor
Member # 2998

posted

GIGI or anyone with pharmacy knowledge,

Can anyone tell me from looking at the Drug interaction chatrs of the P450 Cytochrome system.....what can be taken with Lexapro that will NOT raise the levels of the lexapro.

I need meds that do not go thru the CyP2c19
or the 3A4 or the Cy6 pathways of the liver.

I need to know a safe over the counter pain med, tylenol?? I know Motrin and Asprin are NO NO's!

How about a anti anxiety, I know Xaxax is a NO No!

How about a sleeping aid, I know that Melotonin is a NO NO with the SSRI as well as MIlk Thistle is a definate NO No with all SSRI's.

If anyone understands the charts can you please e-mail me and I can take your recommendations to her doctor to verify.
Drug interactions are difficult to understand with the inhibitors as well as the inducers.If you go on Prozactruth.com and press drug interactions you will find links to three excellent P450 charts.

Thanks,
aunty

Posts: 677 | From USA | Registered: Aug 2002 | IP: Logged |

bpeck
Frequent Contributor (1K+ posts)
Member # 3235

posted

If you have the specific P450 pathway you
know the drug uses, then you need to research the drug you want to combine with it.. and the inter-actions can be any one of 3 - or ** all ** three ( the interations are: Inhibitor, inducer or substrate).

You can search using those key words with pharmakinetics or (if it's a drug as oppossed to a supplement) you can contact the drug company.

Flockhart has the best P450 chart I know of, and it's updated regularily.

Barb

Posts: 1882 | From VT | Registered: Oct 2002 | IP: Logged |

auntybiotic1499
LymeNet Contributor
Member # 2998

posted

B Peck,

Can you explain the differences between the subrate, inhibitor and inducer. That is what I am having trouble grasping. If Lexapro is a inducer of the C6 pathway and Xanax is also using that pathway what happens? Are levels of Lexapro raise or levels of xanax raised. No place explained this process.
aunty

Posts: 677 | From USA | Registered: Aug 2002 | IP: Logged |

TheCrimeOfLyme
Frequent Contributor (1K+ posts)
Member # 4019

posted

All you need to do is check the drug interactions, and it will show where the P450 , if so, is being inhibited by a macrolide, etc.

Biaxin and Zoloft? Serotonin syndrome
Biaxin and most anything that uses the P450 ? Serotonin syndrome. End result? Can be death.

MOST ANBIOTICS AND ANTIDEPRESSANTS ARE NOT TO BE TAKEN TOGETHER.

Im done preaching that though. Ive been for a year, and not a soul has listened./

Posts: 3169 | From Greensburg, Pennsylvania | Registered: Jun 2003 | IP: Logged |

Kira
LymeNet Contributor
Member # 2676

posted

Hi there,

Can you share what test you did, or how you came to learn that these particular liver enzyme pathways or problematic as far you being able to metabolize certain meds...

I highly suspect this in myself because I always get toxic when given certain meds...but docs never seem to believe me... Sure would help if I had "proof" so I could avoid having to prove to them the hard way that I can not take certain meds!!

Kira

Posts: 802 | From Chicago suburbs, Illinois | Registered: Jun 2002 | IP: Logged |

Recipegirl05
LymeNet Contributor
Member # 6729

posted

Hi Auntybiotic1499,

Here's the link to the Flockhart Chart. Thanks to bpeck. Yes, it's awesome.

http://medicine.iupui.edu/flockhart/table.htm

Kira----

Also, if you go to www.drugdigest.org
you can click on drug interactions just like COL said.

Then you place the 2 drugs in the box & press enter.

You'll get a good explanation of why the interaction happens.

Hope that helps.

Take Care,
Jan

Posts: 222 | From Texas | Registered: Jan 2005 | IP: Logged |

Printer-friendly view of this topic

The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA
http://www.lymenet.org/