One test will show low estrogen, then the next will show high. My family history shows typically early menopause. One sis at age 35, one at age 40. I was 45 before I had problems, but Lyme seemed to be the precipitating event.

I stopped getting my period at the age of 26 when I first got sick.. BUT it did return as soon as I started abx.

My hormones are all over the place though.

One of the things that I wonder if it was Lyme long before my last tick bite when I got Lymed for sure was that for years I had an unknown reason for what would happen right before onset of my menses. I did have a tick bite on the head in WIsconsin when I was a kid and but I had normal menses until I was 19 and developed suspected lupus (they kept testing but I never got ANA just all symptoms which went away with penicillin for pnemonia!) So after my "lupus" my period began to go away. 48 hours before onset I owuld run a sudden high fever until I passed out which was the weird thing which baffled docs. Then my period actually consisted of about a teaspoon of blood over 3 days and they told me they thought I was going through early menopause!!! They actually told me they believed I was infertile and when I wanted to get pregnant they were going to "jumpstart" my ovaries" with a bunch of fertility drugs when I got pregnant (was trying!) right away. No doc could figure it out, but years later when I got Lymed for sure, I began to have monster PMS rages exactly 48 hours pre-period almost down to the minute.
I had MONSTER PMS. Never had it before my bulls-eye my whole life, then TA DA!!!!!!!
Tried calcium, etc, no good. After mucho Lyme treatment and when on Mepron, I had major clotting (sorry folks- told oyu graphic) where just tons of blood clots would hit at one day and everyday- tons of blood. After years of abx, I began ot have normal periods again. Now they are normal, at least before I got pregnant again and had the baby. But I expect them to be normal again because they were before I got pregnant. ANywayz, pretty confusing reading over this-

timeline-
tick bite head wisconsin as kid
period normal
suspected lupus age 19
period began to be weird
go away
weird fever pre-menses
hardly any blood
got pregnant & baby anyway
got Lymed & Ehr & Babs
got major PMS first time in life
at same time fever used to hit
48 hours pre-menses
then got treated
period returned to normal
for first time since age 19!!!
oh- and PMS gone*)!*)!*)!

But my period didn't get normal until my treatment for Babesiosis- Mepron- and at first on it it got really weird with the sudden blood thing-

I had a rough and early menopause and for 7 years I thought my problems were hormone related and am became an expert on hormones and HRT. Yes, I use bio-identical HRT and probably will for a long time to come.

Connie-you said your estrogen is all over the place. Of course. It is different at different times of the day and at different times of the month. You would have to check it at the same time of day and at the same point in your cycle and even then there will be some variation.

IMO, and also in the doc's opinion, that's lots of variation considering the last 2 samples were drawn at the exact same calendar day of the month.

The doc told, me to experiment with the estrogen cream, take it more depending on how I feel that day. So maybe 1/4 a cc one day, and a whole the next. I have bout gotten to the point where I can tell where my hormones are that day.

And the more ill I happen to be at any given time from illness flareup, herx, etc, the lower my hormones will run. Which further complicates how I feel.