LymeNet Flash: Lyme bypasses need for Iron Reminder.

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Lyme bypasses need for Iron Reminder.

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Topic: Lyme bypasses need for Iron Reminder.

treepatrol
Honored Contributor (10K+ posts)
Member # 4117

posted

Lack of a role for iron in the Lyme disease pathogen.

Posey JE, Gherardini FC.

Department of Microbiology, University of Georgia, Athens, GA 30602, USA.

A fundamental tenet of microbial pathogenesis is that bacterial pathogens must overcome host iron limitation to establish a successful infection. Surprisingly, the Lyme disease pathogen Borrelia burgdorferi has bypassed this host defense by Lyme disease pathogen Borrelia burgdorferi has bypassed this host defense by eliminating the need for iron.. B. burgdorferi grew normally and did not alter gene expression in the presence of iron chelators. Furthermore, typical bacterial iron-containing proteins were not detected in cell lysates, nor were the genes encoding such proteins identified in the genome sequence. The intracellular concentration of iron in B. burgdorferi was estimated to be less than 10 atoms per cell, well below a physiologically relevant concentration.

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003 | IP: Logged |

no2lyme
LymeNet Contributor
Member # 6978

posted

Hi TreePatrol -

Having significant iron anemia and was intrigued by your post. However, my brain is very slow today and I am not sure I get it fully. Do you have a translation for what that means?

Thanks!

Posts: 152 | From On Horseback | Registered: Mar 2005 | IP: Logged |

Cher44
Member
Member # 7243

posted

So.....what effects does taking iron cause?
Before I was diagnosed my doc was trying everything to figure out what was wrong with me...B12 shots, then iron supplements.
I seemed to feel worse when taking the iron?
Cher

Posts: 46 | From Maine | Registered: May 2005 | IP: Logged |

treepatrol
Honored Contributor (10K+ posts)
Member # 4117

posted

Its basicaly saying all germs or most need iron Lyme dose not need it at all or very little.

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003 | IP: Logged |

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