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» LymeNet Flash » Questions and Discussion » Medical Questions » Need Bicillin LA? Near Mexico?

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Author Topic: Need Bicillin LA? Near Mexico?
David95928
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Folks, it seems like there is a supply crisis, just as so many have found something that works. Probably this is artifically created by Wyeth as part of a nefarious plan to increase prices above their already criminal levels.
There is an alternative. The Mexican version is called Benzetacil 1.2 IU. It costs about $2.50 per dose. This is not a high-tech drug, as it dates back to the early 1950's, and it's manufactured in virtually every country except Canada. It's world market price is 2-4 dollars per dose, Switzerland to Zaire. Many online pharmacies also carry it. Brand names seem to be based on the local language.
Spanish = Benzetacil
French = Extencilline
Turkish= Penadur
Hindi= Penidure.
Consistently, except for Australia and possibly South Africa, the doseagge runs in .6 IU. increments. Thus it is .6 IU, 1.2, IU, and 2.4 IU.
David

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dontlikeliver
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Just FYI, I was advised by Swiss pharmacist that Extencillin is not long acting.

DLL


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David95928
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DLL,
If the Extencilline was 1.2 or 1.4 IU, that information was incorrect.
Pharmacists in this country have told Lymenet members that Bicillin LA and Bicillin CR are the same thing. Wrong, as long as it's Penicillin G Benzathine and not mixed with another penicillin such as procaine penicillin, it's long-acting.
David

[This message has been edited by David95928 (edited 14 May 2005).]


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Ticktoxic
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Has anyone gone into Mexico to buy meds? Are there any problems with bringing them back accross the border?
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LabRat
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Don't know if this will help but if you can make two trips to Mexico, the first is mostly a scouting trip to find the best price. There can be as much as $1.50 difference per box of Tinidazol on the same street 1/2 block away. Buy what they have in stock which may not be much (they didn't know you were coming) and then order in the amount that you will pick up next time by arrangement. Customs is pretty lenient on the amount you bring back. I ask if there was a maximum amount we could bring back and they said yes, "too much", I ask, how much is too much and he smiled and said ``too much'' is too much. So I guess that if you're a cute girl you can pull a little red wagon, an old hairy-legged boy better be on crutches!

Now, first trip into Mexico, Charlie and his playmate showed me the ropes and I had good results with the Tinidazol I bought across from Brownsville. A year or so later I started buying it across from Eagle Pass and my condition began to deteriorate. You know joints and muscle pain, I put it down to a never ending herx. Looking back with hindsight, I may have gotten counterfeit Tinidazol. I was to the point I said, ``I've got to do something else!'' I started taking 100mg per day of doxy and after a couple of weeks of not getting any worst I started getting better. A side benefit was I could have a margarita everyday, don't know which caused the improvement and afraid now to stop either one but don't tell Mo!

Tinidazol can now be bought here in the states, someone on here mentioned that and I checked with my friends at the drug store and they confirmed it,

The Bicillin LA, comes in a little break open bottle that you add sterile water to and mix prior to injection. I purchased four bottles and broke three getting them home. Them my most powerful wouldn't let me try it. Now I could be wrong but I believe it was labeled Bicillin LA. You sure want to know the names of the stuff your going to use. Talking to the druggist over there is akin to talking with a pusher over here. ''Is this good stuff''? Yeah man, it's good **** I mean stuff!

I guess if you start taking a drug and you improve, it's a good drug, if you don't then it's a whole nother ball game. I'm just saying be careful and pay attention to what your body tells you, (as best you can)!

------------------


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Ticktoxic
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I have used the tinidazole that is sold in the USA now as tindamax, and I don't think that it is as good as the compounded tinidazole that I was using. I have also used some of the Fasigyn from mexico, which is tinidazole also, and I think that it was better than the tindamax.

Tindamaz is expenssive here, like zithro, and it is the same stuff that they sell in Mexico dirt cheap. Drugs are such a ripoff here! A lot of the drugs sold here are made in Mexico anyways, they just put a different label on them.

[This message has been edited by Ticktoxic (edited 14 May 2005).]


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groovy2
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Hi all
When buying meds in mexico you must
be careful. There is a lot of- Fake-
meds floating around there.
As you are walking down the street
look at all the other Fake stuff
in the shops in Mexico.
If you can - take a good package and
one of the meds with you to pharmacy
in mexico. Compare the meds- packaging-
do they look the same -color-size
texture -shine- Break it open-
dose it look the same inside-
taste it -dose it taste the same.
If anything dose not look right
it may not be right-- Be careful-
-The label may be in spanish-
--maybe not-
-- Dont look like a tourest.--
If you can take some one who speaks
spanish well with you. Let them do
the talking-in spanish.
--The pharmacy people
will speak english for sure.
I have bought lots of nystatin pills
that were good. I also bought
some Fake Lamisile- $280 gone.--
I have never used a credit card
to pay --but if possiable might
be a good idea-- or maybe not.
Also it can be better to go deeper
in to mexico--Past the tourest area
- If you have time- money and
are healthly enough- take a little
trip to the interior to buy meds.
Mexico is a nice country and is
not expensive. The people are
very nice and lots of cool things
but you have to be careful. Dont take
anything you cant afford to loose
with you. Dont flash money.
If you are carring lots of cash.
Split up your money and carry in
seperate places on your person-
The cops are usually very crooked.
Dont get into trouble.
You can not win.
Eat hot cooked food only. Drink
soda from bottle --No ice--No water--
Dont eat salid ect.
Mexico is a
very poor country--the people you
see begging Really Need the money
so be as generous as you can.
It will make a big diffrence
in there lives.
As far as bring meds back--
I have never had any problem
-at all- The border guards see
people like you-all day-every day.
So dont freek out-- There is a kind
of gray area in the law-- It is
kind of illegal and kind of not.
Every few years a new law will
be passed and will only be
enforced for for a short while.
The border guards are people too
and know how important the
meds are to you--They have family
or friends who buy meds in Mexico.
They have better things to do
than hassel you.
The guard may ask you what you
brought back with you--tell them
medicine-Keep meds in bag from
pharmacy with any papers.

You Must have your drivers licence.
Have a good trip and have a few Tacos
and a coke for me---Jay---



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Porsche
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Hey all, I just bought some bicillan in mexico, but you have to mix the powder and sterile water together. Does anyone have experience doing this?

There is a 3 ml plastic container of water, but I don't know if it all has to be used? I thought that the 1.2 mu was only 2 cc total, not 3. Help please


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David95928
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More later as I ahve a meeeting. I have used it and used all of the water. If they hurt too much you can substitute 1% lidocaine. Abstract on that to follow.
David

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Christine202
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I spoke with King pharmacueticals a few weeks ago... MyLLMD gave me their contact number.

King originally produced Bicillan LA with another manufacturer that they had a contract with.

This year their contract ran out and the other manufaturer has stopped making it. They are in the process of reinstating the contract and it should be very soon.

King says that they are holding there Bicillan supplies for those with Lyme and Syphillus.


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James H
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The powdered version is mixed with more water than the premixed Bicillin LA in the tubex. This is so it is thin enough that you can mix it properly. So... you end up with 4 cc instead of 2cc in a 1.2m dose. It is not really a problem as the extra volume is just water and absorbs very quickly.

Mexico... There has been a bit of a drug war going on in some areas lately, particularly Nuevo Laredo on the Texas border. Not long ago there was actually bazooka fire exchanged on a downtown street. Quite a few US citizens gave gone 'missing' as well. If you venture into that area be a little extra careful.

For perspective I think as much danger probably exists in places like Dallas, Houston, or Los Angeles. Just use good judgement.

As far as the meds, If you buy from one of the major pharmacy chains like Benavides, you should have no problem with fake meds. Penicillin isn't the type of drug commonly faked anyway. It too inexpensive to be very tempting. On the other hand there have been alot of fake drug scandals right here in the US lately.

I would avoid getting any kind of narcotic, sedative, or antidepressant type drug there, even if you have a prescription.

Odd as it may seem, they have extremely tough laws on those. They can throw you in prison for years for being in possession of them and not having a prescription from a Mexican Dr. on your person at the time. A Mexican prison is not a place you want to be.

Antibiotics and that sort of thing are on the other hand OTC, so you can buy all you want. Supposedly you can bring back a 90 day supply for your personal use. The Customs guys can be crabby sometimes, though. Being polite and respectful helps avoid problems. Don't hide things, that WILL get you in trouble.

Also be aware of the firearms laws. Most of us probably do not carry firearms, but even a single .22 shell in your glove box or pocket (leftover fron a hunting trip perhaps) can land one in prison for years in Mexico. Guilty until proven innocent is the rule.

Otherwise, enjoy your trip to Mexico. It is about the only place you can get your Bicillin anymore it seems.

[This message has been edited by James H (edited 24 August 2005).]


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David95928
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James H addressed the issues better than I could have. Here's an abstract about using Lidocaine.
David

******************************************

Pediatr Infect Dis J. 1998 Oct;17(10):890-3. Related Articles, Links


Lidocaine as a diluent for administration of benzathine penicillin G.

Amir J, Ginat S, Cohen YH, Marcus TE, Keller N, Varsano I.

Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva. [email protected]

OBJECTIVE: Benzathine penicillin G is recommended for secondary prophylaxis of rheumatic fever. Its main disadvantage is local pain and discomfort associated with the injection. Lidocaine as a diluent may reduce this discomfort. We compared the administration of benzathine penicillin G with two diluents; sterile water and lidocaine hydrochloride 1% for penicillin concentrations and pain of injection. DESIGN: In a randomized double blind, crossover trial, 18 children ages 11 to 19 years who required prophylactic treatment for rheumatic fever were randomly divided into two groups. One received an injection of benzathine penicillin G diluted with 3.2 ml of sterile water, followed 1 month later by an injection of benzathine penicillin G diluted in lidocaine hydrochloride 1%; the second group received the same regimen in the reverse order. Serum penicillin concentrations and subjective pain sensation were determined after each injection. RESULTS: Peak serum penicillin concentrations at 24 h after injection were similar for both preparations (0.100 microg/ml for water, 0.102 microg/ml for lidocaine), as were the other serum values measured throughout the month. After 28 days detectable concentrations (> or =0.020 microg/ml) were found in 44 and 291% of the subjects, respectively (P = 0.4). Urine penicillin concentrations on Day 28 were 1.81 +/- 0.25 and 2.31 +/- 0.25 microg/ml, respectively. The pain score immediately after the injection was significantly lower with the lidocaine than with the sterile water dilution. CONCLUSION: Use of lidocaine hydrochloride as a diluent for benzathine penicillin G does not change the penicillin concentration in body fluids and significantly reduces the pain of injection. We suggest the use of lidocaine hydrochloride 1% as a diluent for benzathine penicillin G.

Publication Types:
* Clinical Trial
* Randomized Controlled Trial

PMID: 9802630 [PubMed - indexed for MEDLINE]


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Porsche
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Thanks guys. I was also looking for some mixing instructions, as I can't read the directions on the box. Do you shake it up, or is shaking bad? Now where can I get lidocaine without an Rx? Is it available in Mexico also?
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Stella
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You have been given so pretty accurate information about buying drugs in the border towns of Mexico. There ARE reliable pharmacies - send me an e-mail and I'll research and will give you the names of some of these places. And the exact same companies that produce drugs for the first world countries make them for developing countries. The quality is the same if you buy from these companies!


Buying drugs from a pharmacy in one of the bigger cities is much easier (for example: Mexico City, Monterrey or Guadalajara). So if you know anyone who is traveling to one of the non border towns in Mexico ask them to buy some medication for you.


And don't be afraid of ending up in a Mexican prison! Crossing the border back to the US ALL the officers you will bump into are American officers. There's no need for you to have any contact with Mexican police.


Best of luck,
Stella


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David95928
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Porsche,
Yes, shake it thoroughly. It won't actually dissolve much in water. If you shake it and let it sit for a day in your refrigerator you will find a vial of clear or nearly clear water and a sediment on the bottom. So, it has to be held in suspension.
Other instructions, it's to be injected into the glute, only. Use a one and half inch needle,if you are lean, longer(if you can find it) if you are not. I have had no luck getting it to go through needles thinner than 20 gauge and even then they sometimes clog. When that hapens, it can sometimes be unclogged by aspiration but not always. If that happens, it has to be withdrawn, cleared by aspiration and then pressing a little bit through the needle, then re-injected. On bad days I've had this happen like three consecutive times. All of that can cause excessive scarring so, lately, I've gone back to an 18 gauge needle. They almost never clog. They look pretty scarey, like a nail, but I can't actually feel any difference. They are hard to get but a pharmacy near a hospital can probably do it. There is a web site called androusa.com that sells this kind of stuff.
About Lidocaine without a prescription, I have no idea. It's inexpensive here if you can get a physician to prescribe it. It's my recollection that it can interact withthe heart, so going through channels might be wise. Also, you may not need it. I don't use it because the discomfort doesn't seem excessive to me and I prefer not to add one more thing I could react to. It might be possible to react to the lidocaine, assume it's a penicillin allergy and a bandon something that might really help you. My non-medical suggestion is that you start out without it and see how it goes bofore complicating things further
Other questions, just ask.
David

[This message has been edited by David95928 (edited 25 August 2005).]

[This message has been edited by David95928 (edited 25 August 2005).]


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Porsche
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Thanks David.

I think that I will try it without lidocaine. No sense in complicating it. Now the needle size is a different story. I was hoping that the solution would be thin enough this way to use a 25G x 1" needle. I'm really skinny so there isn't any fat to go through. I thought that only the premixed bicillan was thick, and so needed a thicker needle? I remember reading a couple of posts from people who said that they were using a 25G needle.

The other question I have is about aspirating to check for blood before injecting. Is this really necessary? I will be doing them on myself, and it is hard to do this when doing them in the butt. It also seems to me that this procedure is likely to result in nicking a small blood vessel because of the unavoidable movement of the needle. So what do you think?


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David95928
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Hey Porsche,
If you can get to go through a 25 gauge needle, that will be great. I can't get it to go through a 21, reliably. Premixed Bicillin is availble with 1.25 and 1" needles, so obviusly some people get it through the shorter needle.
Aspirating is critical as getting it into the artery that runs through the glute could be catastrophic, like needing a graft to the artery! I think I got it into a small blood vessel once because I had an immediate reaction of vertigo and sweating. It was scarey but subsided pretty quickly.
Is there any chance that you can get someone else to stick you because reaching, especially to my non-dominat side is kind of awkward?
I highly recommend you get your doctor's nurse to give you the first several and teach you how to do it.
David

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James H
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Actually, there is very little difference in what you feel from being stuck with a 25g needle versus even an 18g if it is inserted quickly AND the needle has not been dulled somehow.

If you are usig a dry penicillin, put on a new needle after drawing it into the syringe and you will find the whole process more comfortable. The rubber stopper dulls the needle.

I would not recommend a 25g with a penicillin because you want to immediately know if you are in a blood vessel. It is too easy for a little of the penicillin to get into the bore of a small needle and mix with the blood, clogging it so you do not see the blood when you pull back.

You DO NOT want to inject this into a vein, so be absolutely paranoid about doing so.


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Porsche
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It's not a problem for me to do the shots on both sides by myself. I have been doing B 12 shots for a year with no problem. I was just thinking that there might be less of a chance of nicking a small bl vessel if I didn't try to aspirate. The movement of the needle can do unneccessary damage.

I have noticed that even with the thin soution of B 12 that there is always a little tissue that gets stuck in the end of the needle. It does take a little bit of extra pressure to get the solution moving. I think that this is going to happen no matter what size needle is used. Tissue is soft, and there really isn't much diameter difference between 18 and 25g. The smaller needle does do less damage though. Something to consider when having to do so many shots for a long period of time. If the solution will go through a 25g needle easily outside the body, then it would go through inside the muscle also. I'll have to give it a try and see.

James, you said that with a smaller needle that penicillan might get stuck in the needle and keep the blood from drawing back. I would think that that same problem could happen with tissue clogging up the end of the needle as it is inserted. Am I wrong?

David, As far as getting it in an artery: I thought that that couldn't happen as long as the shots were done in the specified areas? Doesn't this keep the needle away from the sciatic nerve and artery?


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David95928
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Porsche,
If you stay well up in the upper outer quadrant you should miss the artery. Part of what I've experienced is that I start running out of space and push the boundary a bit, although usually with more benign stuff like B12. I don't mean to be real alarming, you just must aspirate. There are only a hndful of cases of accidental injection into the gluteal artery in the literature despite the fact that the military uses TONS of the stuff as pnemonia prophylaxis during basic.
David

[This message has been edited by David95928 (edited 26 August 2005).]


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Recipegirl05
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Hi David,

Thanks so much for posting this information about Bicillin. It's a great help. I'm printing this thread out, too.

Still on Diflucan due to a longstanding black fungal ear infection. Will probably start Bicillin at Sept. visit??

Hey James - home you & your family are doing well.

Take Care,
Jan


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Panchito
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I happened to be in Mexico in february this year, not for buying meds, but just on holiday. Since I was there I thought let's check prices and stock up on cheap meds. I checked for fluconazole, the branded / onnovator product Diflucan, and the price was much higher than in the UK. so I forgot about it... It was in playa del carmen though so very touritic and probably not the best place to get cheap meds...

Adios

Ronald


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