RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe.
S R Holbrook, J L Sussman, R W Warrant, G M Church, and S H Kim
This article has been cited by other articles in PMC.
Abstract
X-ray crystallagraphic studies studies indicate that there are at least four site-specifically bound hydrated Mg2+ ions, [Mg(H2O)n]2+, in yeast tRNAPhe. The size and the octahedral coordination geometry, rather than the charge, of [Mg(H2O)N]2+ appear to be the primary reasons for the specificity of magnesium ions in site-binding and in the stabilization of the tertiary structure of tRNA.
Bb FOLLOWS THE CHOLESTEROL PATHWAY
Gram-positive cocci, and the spirochete Borrelia burgdorferi employ exclusively the mevalonate pathway (Rohmer 1999; Kim et al. 2000; Wilding et al. 2000a, b).
***statin drugs as well as magnesium inactivate the enzyme 5-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase).*** http://www.lef.org/whatshot/2004_11.htm
MAGNESIUM PUTS THE BRAKES ON THE GLYCOLYSIS (SUGAR) PATHWAY
AND...Mg regulates PFK...which puts the brakes on glycolysis...using sugar, not oxygen to make ATP (energy)...this is bad...we don't make nearly enough ATP via the sugar route.
"We hypothesize that extracellular Mg2+ regulates PFK and glycolysis in these neoplastic cells not by entering the cytosol but by a specific interaction with the plasma membrane."
PMID: 1832860
[This message has been edited by Marnie (edited 04 July 2005).]
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Marnie
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To the top because someone asked about taking Mg while fighting yeast.
This is important...very.
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robi
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Can you tanslate? SO is Mg good for fighting yeast?
(Statin drugs/Mg totally shut off the production of cholesterol in the liver)
Bb uses the nutrients WE need to make cholesterol.
It looks like melatonin can be fatal to Bb (Please note...supps. not avail. in Japan...they feel it can be extremely dangerous!)...melatonin info. from my Western Fence Lizard post.
I am taking an educated guess here...another "defensive move" our body takes is to produce a lot of serotonin -> melatonin (to try to knock off Bb). Hence, the fatigue.
Although not making enough ATP (bursts of energy in every cell) is also a huge contributing factor to fatigue.
When we use sugar to make ATP instead of oxygen, we make a LOT (!) less ATP. This isn't healthy...at all.
Bb has control of the sugar route...it keeps it coming...the brakes are off.
This leads to many other problems as well.
In my second post above..just re-read the sentences I "shouted"...words all capitalized.
Mg is good for fighting Bb...THEN yeast won't "need" to be in great numbers...to lower cholesterol.
Look at the Romanian abstract...page one of my Updated Nutshell post. It appears Mg levels take about a 33% drop early on. YIKES!
[This message has been edited by Marnie (edited 05 July 2005).]
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Yeast can be good, as it lowers cholestrol by binding with magnesium, and Bb loves cholestrol. That also means a diet with as little cholestrol as possible will help. Right?
Magnesium is good, because it does something to the cholestrol pathway but also to the sugar pathway, and Bb loves both.
That would mean a strict yeast diet isn't very good for you? I mean, I've tried it and I think you get a lot of cholestrol from it with all the eggs and stuff. So a moderate diet would be better, not too much sugar but also watch the cholestrol? Not kill the yeast entirely but keep it under control?
That makes me wonder about this sugar pathway - does it matter at all what kind of sugar you eat? Like would natural sugars from fruit be better? Or is it just about blood sugar levels?
Further you think that we feel tired, because our bodies produce more serotonin which makes you feel sleepy. Our bodies do this because serotonin turns into melatonin which kills Bb. Did I understand that correctly? Would this mean taking certain types of sleeping pills will help defeat Lyme? Maybe light-therapy? Also interesting to know what serotonin does to your mood. I think it's involved in depression and mood disorders, I'll go look through my neuropsychology books. I wonder if any research has been done on serotonin levels in lymies?
Posts: 185 | From the Netherlands | Registered: Mar 2005
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Marnie
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You are catching on...I'd love to see melatonin levels in early lyme patients and acetlycholine.
pH levels are critical. Got to keep the body slightly alkaline.
pH stands for potential of hydrogen.
How much hydrogen is "available".
To make hydrogen...acids (neg, charge)...lots..react with a little mineral OR glycogen (pos. charge) -> hydrogen.
We are making it every split second constantly. It is critical to being healthy.
Toxins are acidic...the body is way too acidic and guess what makes this situation WORSE...
See my reply about lyme rage...
[This message has been edited by Marnie (edited 05 July 2005).]
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just wanted to add one piece of info which may be relevant. Magnesium is a necessary cofactor for the glycolytic pathway, so it's needed for the body, yeasts, etc. to break down sugars. Since its a cofactor i don't think it's accurate to say it directly inhibits glycolysis unless maybe it does so at very high concentrations or something?
Posts: 122 | From San Diego, CA, California, United States | Registered: Mar 2005
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So, does anyone here use melatonin to help with their sleep problems............and did you notice any herx?
Teddi
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mlkeen
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Yes, I take 1/2 mg melatonin per the llmd for sleeping. It helped some. Didn't notice a herx, but I rarely do.
Last week someone mentioned taking mg and zinc at bedtime, so I moved the abx earlier and take 400 mg malic acid and 12 mg zinc picolinate at bedtime with the melatonin. I sleep like a rock for 5-6 hours, use the bathroom and sleep another hour or two. This is great! It has only been a week so too soon to tell long term if this is the answer for me. I'm enjoying the sleep while I have it.
Marnie
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posted
***"We hypothesize that extracellular Mg2+ regulates PFK and glycolysis
in these neoplastic cells not by entering the cytosol but by a specific interaction with the plasma membrane."
PMID: 1832860
(www.pubmed.com)
Melatonin is what helps us to FALL asleep. This is non REM (rapid eye movement) sleep. It has 4 stages. Then REM sleep cycles. This is when "healing" takes place...when proteins are made. Many lyme patients don't get good REM sleep...acetylcholine issues. This is one of Bb favorite things...Acetyl CoA.
[This message has been edited by Marnie (edited 07 July 2005).]
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So..... let's get some clear answers here. Should LD patients take more Mg and also add in an unspecified amount of Melatonin to their regimen?? I already do take some Mg, but probably need more. No Melatonin but I will try just about anything.
Posts: 183 | From Craley, PA | Registered: Jul 2004
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Sue vG
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I've been finding lately, even when taking magnesium malate before bed, that I wake up almost hourly. Apnea is part of it and my DH is going to start letting me use his CPAP, but man, this is killing me lately.
Marnie, you say we're having acetylcholine problems that interfere with REM sleep - you seem to be saying we need MORE of it?
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