I had that problem prior to the Lyme diagnosis and it was misdiagnosed as herpes. In fact, they were aphthous ulcers. A different doctor suggested vitamin e salve and that helped some. Further research on my part led me to conclude it was a vitamin b deficiency. I was already taking b12 but started taking b complex, orally. When this did not help my doctor and I decided I would try vitamin b complex IM. That did the trick as well as taking care of chronic insomnia.
So, I say vitamin b deficiency. Posted below are symptoms I gleaned from a variety of sources. I showed this to my doctor and the correlation with numerous problems I was having was startling.
DavidCFS/B Complex Deficiency Symptoms?
MedLine Only
Symptom Experimental Anecdotal
1. Fatigue (moderate) B1 B1, 12
a. Just can't do as much in last couple of years
b. Frequently think to myself ``I'm so tired''
2. Joint pain B5
a. Especially hands, variable
b. Toes
c. Elbows
3. Tingling, aching hands B1, 6, 12 B5
4. Concentration, coordination, cognition B1,
a. Difficult to stay task-focused
b. Forgetting names of things/people
c. Missing shifts of gears (better since B-Complex)
d. Word substitution (money/mother)
5. Pain in arms and legs B1
6. Dry eyes B2, 3 B12
a. 6-9 months have been using drops X 1-2 per night
b. 6-9 months gritty sensation
7. Sore lymph nodes in neck (years) B3, 6
8. Recurrent sore throat (years) B1, 2, 3, 6
9. Interrupted Sleep (6-12 months) B1
a. Frequently wake up at 1:00
b. Again at 3:00-4:00
c. Often can't get back to sleep and arise at4:00
10. Aphthous ulcers (less frequent since B12) B2, 3, 6 B 1, 2, 6, 12
11. Angular stomatitis (less frequent/severe since B12) B2, 6
12. Scalp lesions, not acthinic keratoses (Seborrhitic?) B6
13. Breathlessness B1, B5, 6
14. Itching scrotum (poor response to Mentax) B2
Applicable Risk Factors for Deficiency
1. Thyroid illness B1, 2, 3, 6, 12
2. Intestinal problems B1, 2, 3, 6
3. Stress B1, 2, 3,6
4. Continuing infection B2, 3, 12
5. Mouth or throat sores B3
6. Stomach disease B12
7. Long-term illness B1, 2, 6
Changes noted since starting use of B-Complex Injection 5/6/02
Entry for 5/9/2002
1. Slept through the night on 5/6 for the first time in about a year. On 5/7 & 8 was awakened by Boris (the dog) but was able to go right back to sleep.
2. Spasm in right foot alleviated substantially on 5/7
3. Experienced a sense of ``lifting'' and relaxation of chest
4. Soreness on edges of tongue (months) resolved
5. Scrotal itching substantially alleviated