Did your dr use Igenex Labs?? If not, you're very likely to come up negative. Other labs do not test for all the bands. Igenex labs specializes in Lyme testing.Going to a dr who doesn't specialize in Lyme gets you nowhere......testing thru a lab that doesn't specialize in Lyme gets you nowhere.
REASONS WHY A SERONEGATIVE TEST RESULT MIGHT OCCUR
1. Recent infection before immune response
2. Antibodies are in immune complexes
3. Spirochete encapsulated by host tissue (i.e. lymphocytic cell walls)
4. Spirochetes are deep in host tissue
5. Only blebs in body fluid; no whole organisms needed for PCR
6. No spirochetes in body fluid on day of test
7. Genetic heterogeneity (300 strains in U.S.)
8. Antigenic variability
9. Surface antigens change with temperature
10.Utilization of host protease instead of microbial protease
11.Spirochete in dormancy phase
12.Recent antibiotic treatment
13.Recent anti-inflammatory treatment
14.Concomitant infection with babesia may cause immunosuppression
15.Other causes of immunosuppression
16.Lab with poor technical capability for Lyme disease
17.Lab tests not standardized for late stage disease
18.Lab tests labeled "for investigational use only"
19.CDC criteria is epidemiological, not a diagnostic criteria
FDA bulletin on testing: http://www.fda.gov/medbull/summer99/Lyme.html
For what it's worth......I also was sero-negative....even thru Igenex. I believe it is because I had been given steroids [alot] a few yrs before my testing...also I've had Lyme for over 46 yrs....I think that affected my test results.
My first WB was neg......then I took abx for several wks, then off for 2 wks and took it again........More bands showed up and I was one band away from CDC positive.
I had bands which were specific to Lyme, so what else could it be???????
Be sure to read this carefully. You'll see what I'm talking about.
Western Blot explanation: http://flash.lymenet.org/ubb/Forum1/HTML/022767.html
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Do not take anything I say as medical advice. I am not a doctor, but I DID stay at a Holiday Inn Express!
oops!
Lymetutu