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» LymeNet Flash » Questions and Discussion » Medical Questions » Sons WB IGM results higher after abx

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Author Topic: Sons WB IGM results higher after abx
briteeyes30
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My son was tested first when he had the EM rash and lyme meningitis. His results were positive through quest for 5 bands IGG and 2 bands IGM.

When I found Dr J austin had already been on his iv meds for 3 weeks and 1 week left to go. Dr J extended his meds for 2 months more due to still showing symptoms. They took blood and sent it off to Igx and quest.

The results from this one were IGG 5 bands and IGM 6 bands. Why would the IGM go from 2 bands to 6 bands?

The following week after dr J visit is when austin started to herx due to all these symptoms popping out during the 4/5 week of abx and they also switched his abx from rocephin to claforan.

Anyone help me understand plz


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lou
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Well, Dr. J could give you a better explanation than any of us, but I wonder if it is because his immune system is now producing antibodies more efficiently. Some people who are completely seronegative become positive after treatment because of this.
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Lyddie
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This happened to me.

Sometimes, the meds stir the bugs up from their hiding places, and more antibodies are produced. This would seem to be more likely with a longstanding infection, in which the bacteria had already sequestered in tissues.

Immune system issues might also affect antibody production, as Lou said, and maybe abx restore some immune function-?

Dr. J could definitely explain. But just so you know, this is not at all uncommon.


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