Lymecycline belongs to a group of antibiotics called tetracyclines. It is an antibiotic which has the ability to inhibit the growth of a wide variety of bacteria. It interferes with the production of proteins that the bacteria need to multiply and divide. This inhibits the ability of the bacteria to grow (bacteriostatic) and therefore stops the spread of the infection.
What is it used for?
* Acne vulgaris
* Chronic bronchitis
* Dental infections
* Disease caused by infection with Leptospira bacteria (Weil's Disease/leptospirosis)
* Infection caused by Brucella bacteria (brucellosis)
* Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites
* Infections of the sex organs and organs associated with urination (genito-urinary infections)
* Lyme disease
Use with caution in
* Kidney disease
* Liver disease
Not to be used in
* Children under 12 years of age
* Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
* Severe kidney disease
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
* This medicine should not be used in pregnancy. Seek medical advice from your doctor.
* Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers. Discuss this with your doctor.
Label warnings
* Do not take iron preparations or indigestion remedies at the same time of day as this medication.
* Take at regular intervals. Complete the prescribed course unless otherwise directed.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
* Headache
* Rash
* Diarrhoea
* Visual disturbances
* Inflammation of the pancreas (pancreatitis)
* Inflammation of the large intestine (colitis)
* Damage to the liver
* Nausea and vomiting
* Abnormal reaction of the skin to light, usually a rash (photosensitivity)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
The absorption of lymecycline into the body is reduced by: Quinapril (ACE inhibitor) Antacids Kaolin Calcium salts and dairy products Iron Tripotassium dicitrato-bismuthate and sucralfate (ulcer-healing drugs) Zinc salts Magnesium salts
Lymecycline also reduces the absorption of iron and zinc salts.
Lymecycline may reduce the effectiveness of the combined oral contraceptive pill.
Lymecycline may increase the blood thinning effects of anticoagulants scuh as warfarin.
If lymecycline is taken with acitretin, isotretinoin or tretinoin there may be an increased risk of developing raised pressure within the skull (benign intracranial hypertension).
Tetracyclines should be avoided in patients on diuretics as it can cause a rise in blood urea nitrogen levels.
Tetracyclines may decrease the effectiveness of penicillins.
Other medicines containing the same active ingredients
Lymecycline
________________________________________________
Anyone have experience, knowledge or info on this drug?
Posts: 33 | From Oregon | Registered: Sep 2005
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> Eur J Dermatol. 2003 Mar-Apr;13(2):130-5. > > Lymecycline in the treatment of acne: an efficacious, safe and > cost-effective alternative to minocycline. > > Bossuyt L, Bosschaert J, Richert B, Cromphaut P, Mitchell T, Al > Abadie M, Henry I, Bewley A, Poyner T, Mann N, Czernielewski J. > > Leon Spiliarstraat 18A, 8400 Oostende, Belgium. > > A comparison of efficacy, safety and cost-effectiveness of > lymecycline and minocycline in the treatment of acne vulgaris has been > addressed. This was a multicenter, randomized, investigator-masked, > parallel group trial involving patients with moderate to moderately > severe acne vulgaris, receiving either lymecycline or minocycline for 12 > weeks. Efficacy and safety evaluation was performed at baseline and at > weeks 4, 8, and 12 and completed by a pharmacoeconomic analysis > including week 12 data. One hundred and thirty-six patients were > enrolled. At week 12, the mean percent reductions in inflammatory count > were 63 % and 65 %, and for total lesions counts 58 % and 56 % for > lymecycline and for minocycline respectively. Median percent reduction > in non-inflammatory count were 54 % and 47 % for lymecycline and for > minocycline respectively. Eighty-seven per cent of all patients > tolerated the treatments well. Treatment with lymecycline was found to > be 4 times more cost-effective than with minocycline. Results showed > that lymecycline has a comparable efficacy and safety profile to > minocycline while being 4 times more cost-effective. > > Publication Types: > > * Clinical Trial > * Multicenter Study > * Randomized Controlled Trial > > PMID: 12695127 [PubMed - indexed for MEDLINE] > > -------------------------------------- > > http://www.medsafe.govt.nz/profs/Datasheet/t/Tetralysalcap.htm > > *Actions* > > Tetralysal (lymecycline) is a tetracycline chemically bonded to the > amino acid L-lysine. It has been estimated that 408 mg of lymecycline, > equivalent to 300 mg tetracycline base, is equivalent in its action to > 500 mg tetracycline hydrochloride. Lymecycline is approximately 5000 > times more soluble than tetracycline base and unlike tetracycline > hydrochloride it is soluble at all physiological pH values ( a 5% > aqueous solution does not precipitate in the presence of serum). > > *Pharmacokinetics* > > The Tetralysal (lymecycline) molecule is distinguished by a > monoamino-mono-carboxylic acid substituent at C-2 which provides it with > important characteristics bearing on clinical effect. > Tetralysal(lymecycline) is unique amongst tetracyclines in that it is > absorbed by the "active transport" process. Carrier enzymes within the > intestinal wall interact with the drug molecules and draw them into the > membrane. Passing from one enzyme molecule to the next, the Tetralysal > (lymecycline) molecule is carried through the lipid barrier to be > liberated on the other side of the membrane. This method of absorption > is fast and efficient. It is the method by which carbohydrates are absorbed. > > Tetralysal (lymecycline) is stable at all body pH values (from pH 2 to > pH 7.5), high serum tissue and urine levels.
Posts: 33 | From Oregon | Registered: Sep 2005
| IP: Logged |
treepatrol
Honored Contributor (10K+ posts)
Member # 4117
[0051] Tetracycline, as well as the 5-OH (oxytetracycline) and 7-Cl (chlorotetracycline) derivatives exist in nature and are well known antibiotics. Other tetracyclines include, for example, apicycline, chelocardin, clomocycline, demeclocycline, doxycycline, etamocycline, guamecycline, lymecycline, meglucyccline, mepycyhcline, minocycline, methacycline, penimepicycline, piacycline, rolitetracycline, and sancycline.
Pharmacokinetics of lymecycline and doxycycline in serum and suction blister fluid.
Schreiner A, Digranes A.
In an open, random, cross-over trial, 8 young healthy volunteers were given standard doses of lymecycline and doxycycline for 2 days to achieve steady state. The pharmacokinetics of each tetracycline in serum and dermal, suction blister fluid were determined after oral doses of 300 mg lymecycline or 100 mg doxycycline on the 3rd day. Serum concentrations were higher for lymecycline than for doxycycline, the difference being statistically significant from 3 to 9 h after dosing. Also blister concentrations were higher for lymecycline than for doxycycline, though the difference was not statistically significant. The serum half-life for lymecycline was close to 10 h, for doxycycline 12 h. According to our results, both lymecycline and doxycycline should be regarded as 'intermediate-acting' tetracyclines, and each should consequently be dosed twice daily.
Main Use Active Ingredient Manufacturer Bacterial infections Lymecycline. Galderma
How does it work?
Lymecycline belongs to a group of antibiotics called tetracyclines. It is an antibiotic which has the ability to inhibit the growth of a wide variety of bacteria. It interferes with the production of proteins that the bacteria need to multiply and divide. This inhibits the ability of the bacteria to grow (bacteriostatic) and therefore stops the spread of the infection.
What is it used for?
Acne vulgaris
Chronic bronchitis
Dental infections
Disease caused by infection with Leptospira bacteria (Weil's Disease/leptospirosis)
Infection caused by Brucella bacteria (brucellosis)
Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites
Infections of the sex organs and organs associated with urination (genito-urinary infections)
Lyme disease
Use with caution in
Kidney disease
Liver disease
Not to be used in
Children under 12 years of age
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Severe kidney disease
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used in pregnancy. Seek medical advice from your doctor.
Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers. Discuss this with your doctor.
Label warnings
Do not take iron preparations or indigestion remedies at the same time of day as this medication.
Take at regular intervals. Complete the prescribed course unless otherwise directed.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Headache
Rash
Diarrhoea
Visual disturbances
Inflammation of the pancreas (pancreatitis)
Inflammation of the large intestine (colitis)
Damage to the liver
Nausea and vomiting
Abnormal reaction of the skin to light, usually a rash (photosensitivity)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
The absorption of lymecycline into the body is reduced by: Quinapril (ACE inhibitor) Antacids Kaolin Calcium salts and dairy products Iron Tripotassium dicitrato-bismuthate and sucralfate (ulcer-healing drugs) Zinc salts Magnesium salts
Lymecycline also reduces the absorption of iron and zinc salts.
Lymecycline may reduce the effectiveness of the combined oral contraceptive pill.
Lymecycline may increase the blood thinning effects of anticoagulants scuh as warfarin.
If lymecycline is taken with acitretin, isotretinoin or tretinoin there may be an increased risk of developing raised pressure within the skull (benign intracranial hypertension).
Tetracyclines should be avoided in patients on diuretics as it can cause a rise in blood urea nitrogen levels.
Tetracyclines may decrease the effectiveness of penicillins.
Other medicines containing the same active ingredients
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
When I saw this info elsewhere, it was not clear whether it would work on gram negative bacteria. Evidently it does, if lyme is listed.
I know it wasn't named for lyme, but this is too funny. The magic bullet for lyme disease = lymecycline!!! Ha, ha.
(Not looking for magic bullets anymore, but it does give us something else to add to the arsenal, if available in U.S.)
Posts: 8430 | From Not available | Registered: Oct 2000
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