Carbohydrate-based Drug Discovery Volume 1 Chi-huey Wong rpi.edu
Select the first one (of 2) and chose the HTML version.
Go to page 10 and read very carefully. Then research heparin and make the liver link.
Next..."PFK dependent" = phosphofructokinase. Fructose. Sooooo how would Mr. Burgdorferi like Zylitol? Would he change "clothes"? (mutate) Would we need to keep changing his diet? Xylitol does NOT cause an insulin spike. Research this NATURAL sugar too!
P.S. Down below, Welcome put the direct link to the paper. Don't try to read the whole thing...it is REALLY way up there (over most heads), but DO read page 10 and pay attention to malaria and borrelia burgdorferi...where they are mentioned. See what they link onto.
[ 25. October 2005, 03:01 PM: Message edited by: Marnie ]
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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I managed to get to the "Papers" page but can't seem to find the particular paper you might be referring to. What was the title?
Posts: 294 | From nevada | Registered: Sep 2005
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Marnie
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Link fixed...heparin info. REALLY important!
Sorry...computer probs. Hubby added protection and I couldn't post...had to call the geeks.
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Marnie
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Thanks, Welcome! I couldn't get it to work..even cutting and pasting... ???
Computers!!! I know...GIGO...
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SForsgren
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Any thoughts on Nattokinase vs. Heparin? I know some doctors are using it, but others have had mixed results. Heparin is potentially problematic, causes bruising, etc. and the doctors I have talked with about it seem to shy away from its use, even LLMDs.
How many people here have done the hypercoagulation test from Hemex?
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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Carol in PA
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On page 10
Malaria parasite circumsporozoites infect human liver by binding to the highly sulfated human liver HS PG. Liver HSPG also appears to act as the receptor for the apolipoprotein E (apoE).
The bacterial protein BGP from Borrelia burgdorferi, which causes Lyme disease, is a heparin-binding protein, suggesting that infection takes place through bacterial interaction with a HS acceptor.
=========== Marnie, you instructed, "Read page 10 and pay attention to malaria and borrelia burgdorferi...where they are mentioned. See what they link onto." "Then research heparin and make the liver link."
My once agile brain is unable to "research heparin and make the liver link."
This is frustrating for me, it's like a maze where the prize is always just out of reach. I know it's around the corner somewhere, if only I could concentrate. But I can never get to it.
=========== Scott, I agree with your idea of trying Nattokinase instead of Heparin. I read several articles about systemic enzyme therapy, and there are some astounding ideas there, things that could help Lyme patients.
I've been using Wobenzyme for four or five months now, and have dramatically decreased headache pain. Headaches are one of the symptoms of hypercoagulation. I have not been tested, but decided to try systemic enzymes, since I seemed to have the symptoms.
Systemic enzymes strip the fibrin from the bacteria, revealing them to the immune system. Apparently, this is what heparin does also.
Why aren't the LLMD's giving systemic enzymes along with the antibiotics? It would increase the efficiency of the antibiotics.
Surely I'm not the only one who's noticed this. Carol
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SForsgren
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I am going to push my LLMD to run the Hemex test next month and see what happens. Then will consider Nattokinase or even better possibly VitalzymSEB from www.worldnutrition.info. I do take Wobenzym as well and agree that there may be some benefit here to helping with antibiotic tissue absorption.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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posted
Some LLMD's think Lumbrokinase is much more effective than Nattokinase. Can't remember the exact numbers, but I think I have seen recommendations to take 20 Nattokinase daily or 5 Lumbrokinase -- something like that.
Of interest is the fact that the Chinese developed one or maybe both of these enzymes from earthworms which have the ability to regenerate themselves. I think in earthworms the original enzymes worked as coagulants (stopping bleeding) instead of anticoagulants (thinning blood).
WV Hillbilly
Posts: 48 | From Five Mile Creek, WV,USA | Registered: Aug 2005
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I know there is a pubmed article on heparin and babesia. Some LLMD's do still use heparin. Hubby did shots for a while and then sublingual lozenges (very expensive) and now I just use 5000 units of heparin by IV 1 or 2 times daily when he has a really bad headache or eye pain -- sometimes it helps and other times can't tell any difference. Per LLMD IV heparin only stays active 1/2 hour and shots stay active for 4 - 6 hours I think.
Scott,
Dr C in Missouri says that a high percentage of Lyme patients have a genetic clotting defect -- hubby has not had that part of the Hemex test done -- I think it costs $400 or maybe it is $200?
He has had the regular Hemex test done I think it is 3 times -- no real improvement even with heparin shots or sublingual -- probably was not at a high enough dose. Tried nattokinase for a while and Lumbrokinase also -- did not retest while on either of these supplements.
In past when Hemex tests were abnormal (not real bad though) hubby did not have the severe headaches he is having for last 3 - 4 months since stopping all these supplements. Has continued taking gingko and COQ10 and vitamin E so it is possible the heparin or the nattokinase or lumbrokinase were actually helping more than we realized.
As for the enzymes, some people take Wobenzyme or quercetin or bromelain or other proteolytic enzymes. Hubby has tried almost all of them -- couldn't say if any helped as his stomach is so sensitive he could never stay on any of them for any length of time.
You are taking these between meals I assume -- he does take regular digestive enzymes which do help with G.I. function. Proteolytic (protein digesting) enzymes are contraindicated with gastritis.
Marnie,
Just read page 10 only -- If the article is saying that borrelia is hiding inside the blood that is my understanding of the HEMEX test -- the ISAC (Immune System Activation of Clotting) is the standard test panel which shows hypercoagulation and is why heparin is prescribed -- to break down the fibrin clot (thus uncovering the bacteria or virus so the immune system can get at it) and not to thin the blood per se.
Or is the article saying that borrelia bacteria bind to HS (heparin sulfate) making the heparin unavailable to thin the blood as it would normally do ???
Bea Seibert
[ 26. October 2005, 01:37 AM: Message edited by: seibertneurolyme ]
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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Was researching EDTA again and found this -- PMID 11113124 -- See Discussion section of free journal article regarding heparin -- a little over my head but I think this confirms the source you are linking to in this thread.
Bea Seibert
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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I am completely over my head in this type of research. I am certainly missing even the basics.... What is the conclusion?
Marnie, I also noticed previous failry complex and medicallly "intense" theories you are proposing. If you don't mind me asking, what is your background in this, and, as a suggestion for many of us lymies who don't have a lot of science classes in our background, do you mind giving the punch line away in lay terms as well?
treepatrol
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Also used buy Herpes virus
Heparan sulfate = (HS)
Infections caused by herpes simplex virus type 1 (HSV-1) are highly prevalent in human and result in localized mucocutaneous lesions and, in rare cases, encephalitis (5). HS plays critical roles in assisting HSV-1 infections in both viral attachment and entry steps (6). In the attachment step, HSV-1 binds to the cells through the interactions of envelope glycoproteins gC or/and gB with cell surface HS (7). Viral entry requires the interaction of a third viral glycoprotein, gD, with a specific cell surface entry receptor to induce fusion of the viral envelope with the cell membrane (in the presence of gB, gH, and gL) to establish an infection (8). The 3-O-sulfated HS, representing the culmination of a series of specific sulfated saccharide sequences, binds to gD and serves as an entry receptor of HSV-1 (9, 10). The 3-O-sulfated HS is synthesized by heparan sulfate 3-O-sulfotransferase isoform 3 (3-OST-3) and by 3-OST-5 (9, 10). A gD-binding HS octasaccharide was isolated and characterized, confirming that HSV-1 utilizes a unique HS sequence for its entry (11). Understanding the biosynthesis of 3-O-sulfated HS could potentially lead to a new strategy for developing therapeutic agents against HSV infection. From here
Whoa!!!!!!!!!!
Heparan may cause spreading of disease also. Cause cancer too metastasis.
Heparin and cancer Heparin affects the progression of cancer in many ways. Because of its anticoagulant function,heparin can inhibit thrombin and fibrin formation induced by cancer cells . Heparins may therefore potentially inhibit intravascular arrest of cancer cells and thus promote metastasis. Bad bad badbad thing!!!!! From here in PDF Scroll down to 414 I 15 just above details on lyme and Alzheimers section.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
SForsgren
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Thanks Bea. This is one of the best and most important threads I have seen in awhile. I am looking forward to talking more with my LLMD about this next week and getting the Hemex testing done. Best
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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Marnie
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Not too long ago...researchers felt that we should BLOCK the blood vessels that are delivering nutrients to cancer cells.
But other researchers feel...what IF blood vessels are delivering the nutrients to knock off/control the cancerous cells?
Cancer cells most DEFINITELY follow a glycolysis (they uses sugar for energy) pathway! This has been known for YEARS.
(Look VERY closely at H16...there IS a link somewhere! Hydrogen is THE KEY "antioxidant". The chemical formula of things that contain H16 are quite amazing.)
From a PRACTICAL standpoint...I would consider Warfarin (H16 is in the chem. formula.). From a nutritional standpoint..Mg with B vits.
Okay...disbelievers: ;-)
Heparin, and particularly low molecular weight heparin, is widely used for the treatment of patients with deep vein thrombosis (DVT) and the prevention of DVT that commonly accompanies malignancy. PMID: 12172439
Article date: 2003/07/10 A new study suggests low-molecular weight heparin may be more effective at treating blood clots in cancer patients than the commonly used anti-clotting drug warfarin (Coumadin). Researchers from Canada and several other countries found the heparin further reduced the chance of a new blood clot forming and didn't lead to any more bleeding.One expert suggests low-molecular weight heparin should therefore become standard treatment for blood clots in cancer patients.
Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling. Since pancreatic cancers over-express a number of heparin-binding growth factors and their receptors, the expression and function of this enzyme in pancreatic cancer was analyzed. tp://www.molecular-cancer.com/content/4/1/14
Can Heparin Fight Cancer? Recent research results have backed up the theory that the body's coagulation mechanism may play a part in the development of some cancers, as well as offering some explanation of why heparin might interfere with cancer.1,2,3,4,5,6 Heparin has been shown to fight the growth of tumors in animals in various ways.7,8,9,10,11 Some of these studies have also shed light on why heparin, and not warfarin, might have this effect.12 There is also preliminary evidence that LMWH treatment prolongs survival in patients with both DVT and cancer.13
The possible reasons for this are not completely understood. To put them as simply as possible, cancerous tumors are usually surrounded by a substance called fibrin. Fibrin promotes the growth of the tumor and the growth of new blood vessels that supply the tumor with necessary nutrients. Heparin interferes with fibrin formation and perhaps directly inhibits the formation of new blood vessels. Both heparin and LMWH may also inhibit tumor growth in other ways.14,15,16 http://www.thedoctorwillseeyounow.com/articles/cancer/hep_4/
CONCLUSIONS: IL-10, IL-6, and P-selectin levels predicted a poor outcome in patients with advanced stage malignancy. The prolongation in ***survival*** observed with LMWH in patients with cancer apparently cannot be explained by a LMWH effect on these circulating markers. Cancer 2005. (c) 2005 American Cancer Society.
In cancer patients, cerebrovascular accidents (CVA) are the most common complication occurring in the central nervous system after metastasis. ...The results of the analyses of most patients reveal chronic disseminated intravascular coagulation. The most valuable diagnostic tests are the transesophageal echocardiogram and magnetic resonance imaging of the brain with diffusion sequences. Preferred treatment is with heparin.
PMID: 16193446
These results may help to explain the well-known ability of heparin to
inhibit the growth of primary and metastatic tumors.
PMID: 16176582
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For Professionals: Highlights of Orthomolecular Health Conference on the Heart and Lyme Disease, Feb 14-17, '05
Dr David Berg from HEMEX Laboratories spoke on ISAC, Immune System Activation of Coagulation, a condition in which coagulation cascades are activated leading to decreased blood flow. This is seen in a number of chronic illnesses, including Lyme disease and can correlate with increased pathogen load. Considering that a capillary is 8-10 um in diameter and a red blood cell (RBC) is 7 um, any blockage could retard blood flow. When the blood flows smoothly oxygen diffusion time is 2 seconds. When the capillary is clogged with fibrin the oxygen diffusion time is 5. 3 minutes. With Lyme patients, 89% of them had positive ISAC panels, meaning their blood flow was not normal. Heparin restores blood flow and may be effective with psychotic individuals when their psychosis is due to reduced blood flow. One physician had seen dramatic response in a psychotic patient using Heparin alone. HEMEX solves "blood curdling mysteries."
Bea Seibert
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Marnie
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Besides interfering with coagulation (fibrin), I wonder IF giving heparin works the same way as this did:
Blood Pressure Enzyme May Help Battle SARS By RANDOLPH E. SCHMID, Associated Press Writer Mon Jul 11, 7:11 AMUPDATED 21 HOURS 15 MINUTES AGO
WASHINGTON - An enzyme that regulates blood pressure also is involved in infection by the SARS virus, a discovery that may lead to new ways of treating diseases that cause lung failure.
Learning how SARS (severe acute respiratory syndrome) became a deadly threat "possibly teaches us a lesson on how to actively fight so diverse and dreadful diseases as SARS, avian flu or the effects of such biotech weapons as anthrax," said Dr. Josef Penninger of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences.
The research may have wider implications for a type of lung failure known as acute respiratory distress syndrome, Penninger reported in a communication to the journal Nature.
It can occur in cases such as sepsis, aspiration of gastric contents, pneumonia and both avian and human influenza.
What those diseases have in common is a type of lung failure.
Penninger and colleagues report in Monday's issue of Nature Medicine that, working in mice, they ***found that angiotensin-converting enzyme 2 (ACE2) is a crucial receptor for the SARS virus.
The result is disruption of the body's protective renin-angiotensin system, leading to respiratory distress syndrome as fluids seep into the air sacks. The renin-angiotensin system uses enzymes to regulate sodium balance, fluid volume and blood pressure.
SARS was first identified in 2003, originating in China and spreading rapidly to Asia, Canada and elsewhere. It killed nearly 800 people and disrupted travel, economics and even some scientific meetings.
***The researchers found that the SARS virus binds to the ACE2, Penninger said in a telephone interview.
If disabling ACE2 allowed lung damage to occur, ***the researchers wondered whether providing more of the enzyme would help.***
They created more ACE2 and infused it into the mice. The result was to protect mice from the lung failure effects of SARS.
It was effective in two ways, Penninger said. First, ACE2 combined with the virus and prevented it from binding to normal cells. Also, the enzyme protected the mice from acute lung failure.
"We of course need to extend these findings in mice now to humans," Penninger said. "Yet in essence, SARS pointed us to a protein that may help millions of people affected with a previously untreatable disease."
A commentary by John Nicholls and Malik Peiris of the University of Hong Kong said the findings indicate that the potential therapeutic value of ACE2 and angiotensin 2 receptor inhibitors for acute lung injury will be a productive field for investigation.
But Peiris and Nicholls, who were not part of Penninger's team, said there are differences in the way SARS binds with human ACE2 and ACE2 in mice.
The research was funded by the Austrian Academy of Sciences, Austrian National Bank, Marie Curie Fellowship of the European Union, Beijing Committee of Science and Technology, National Natural Science Foundation of China, Joincare Corporation, Canadian Institutes of Health Research, Canada Foundation for Innovation and the German Research Council.
IF giving "extra" heparin, does the pathogen or it's "babies" lock onto the excess and then does not cause the damage and is able to be eliminated easier by our own system - antibodies - or by antibiotics?
Food for thought.
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heiwalove
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marnie,
while i very much appreciate all the time and effort you put into researching lyme, when you yourself are not even a lyme patient (you obviously have a generous heart), i am disturbed by your lack of response to repeated requests for laymens' translations.
this info cannot help us if we can't grasp it; and most chronic lyme patients, as you know, struggle with brain fog. simple tasks are often difficult; this sort of language might as well be chinese. (even for me, and i hardly suffer from brain fog at all anymore. i simply have a history/writing&english background, and not a science or math background. and honestly, i don't have the time or the energy to sit around and try to understand all the crazy complexity myself.)
if you don't have the time/energy to translate, that's understandable.. maybe enlist the help of someone else who comprehends all your research?
GiGi
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You may want to consider Rechtsregulat, which is now available at Biopure (last I heard which was before I went to Europe over a month ago). The following is from Dr.K's comments re fibrin. You can find the whole article on his website www.neuraltherapy.com/articles/Lyme Disease: A look Beyond Antibiotics.
We used during our cure and still use Rechtsregulat on a regula/not daily basis.
Why do we lack enzymes? Early harvesting, long storage and processing, heating, sterilizing. All these processes destroy enzymes that are necessary for life.
From the article:
"1: Anergy - the absence of reaction due to the successful evasion of the host-defenses . One of the more known mechanisms the microbes use to create anergy is hypercoagulation. The microbes tend to live in the endothelium, where the food is most abundant. They trigger the host's coagulation mechanism to lay down a layer of fibrin on top of them to evade recognition by the immune system. etc. For this aspect we use 3 techniques: a) the KMT-microcurrent technology and homeopathics to wake up and entrain the immune system
b) Rechtsregulat (``right rotatory fluid'') which is an enzyme rich extract of fermented fruits and vegetables (14). It has outperformed the s.c. injection of heparin in our own trials. Lumbrokinase is far more effective then Nattokinase. Both appear weak when compared to Rechtsregulat. We also client's system (geopathic stress, EM stress, food allergies, emotional factors, interference fields such as scars and disturbed ganglia and we substitute vitamins and minerals based on ART testing)."
Take care.
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IF giving "extra" heparin, does the pathogen or it's "babies" lock onto the excess and then does not cause the damage and is able to be eliminated easier by our own system - antibodies - or by antibiotics?
Food for thought.
On the other hand, providing an abundance of what it is looking for may promote its replication, ie, more "food", more babies. The trick would then be to help the immune system at the same time with targeted (Lyme specific) supplements?
Posts: 294 | From nevada | Registered: Sep 2005
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"Mycoplasma responds well to enzymes, when it is treated in sequence with the other microbes as outlined here. The most effective strategy is the German product Rechtsregulat (14). This simple drink has been extremely effective in eradicating mycoplasma and other cell wall deficient microbes. It also has a heparin like anti-fibrin effect that surpasses injected heparin by far. It has just like heparin, a strong biological effect against Babesia as well. Dosage: 1 tbs/2 times per day."
What percentage of LD patients have elevated Blood Glucose levels, or problems maintaining Blood Glucose levels in normal range? Am curious about something here.
What, if any, effect or interaction does insulin have on/with HS? And, considering your liver link here, should GH and IGF-1 be looked at here?
Awww....maybe I'm just Posts: 67 | From Kansas City, MO | Registered: Sep 2004
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