posted
Hi Everyone. I went to my LLMD appt this morning and he agreed that we should treat this as if it is lyme until we get a positive test back.
He took me off of the Doxy (2.5 months at 400mg/day) and replaced it with 1000mg Ammoxicillian 4 times a day.
I am new to Lyme treatment and am wondering what the average doseage of Ammox is? Going from 400mg of Doxy to 4000mg of Ammox sounds extreme. Is it?
Can someone tell me what doseage is "normal" with ammoxicillian?? Thanks. Michelle
Posts: 64 | From Pittsburgh | Registered: Sep 2005
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
Review the Dr. B protocols. They are on the front page of my site (link below).
*Amoxicillin- Adults: 1g q8h plus probenecid 500mg q8h; doses up to 6 grams daily are often needed Pregnancy: 1g q6h and adjust. Children: 50 mg/kg/day divided into q8h doses.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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Areneli
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Member # 6740
posted
Amoxy is non-toxic and if you can tolerate it well go to higher doses such as at least 8 g per day or more. Many people went up to 12, 18 or 27 g per day. I have been on 12 g per day or more for more than 6 months total and it doesn't bother me at all.
I have found other ABX such as tetra or metronidazol to be more problematic in low doses.
Posts: 1538 | From Planet Earth | Registered: Jan 2005
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posted
I'm officially confused now. I thought that 4000mg/day was actually the highest one should take. Obviously that is not the case.
Since I have primarily neuro symptoms should I be asking the Dr. why I am on a low dose of Ammox? I was on 400mg day of Doxy for 2.5 months and my LLMD decided to change me to Ammox today.
What are some thoughts out there. Anything will be helpful. Just want to be sure I am my own advocate here.
oxygenbabe
Frequent Contributor (1K+ posts)
Member # 5831
posted
I asked a question about amoxy so maybe if you use that search term you'll find my thread. Many answered helpfully and they took 4.5-6 grams daily usually, sometimes more. Some felt it was a lifesaver.
Remember, penicillins like amoxy are bactericidal, they will lyse and kill spirochetes. Doxcycyline will not. It inhibits it but what is the point of that in a slow growing infection--it means 2 weeks won't by any means ge it all. I can't figure out why they give it at all, therefore...okay, it gets erlichia too, but do they really care so much about coinfections? If they did wouldn't they regularly test for bartonella and babesia too? No, its just medical idiocy as usual. Posts: 2276 | From united states | Registered: Jun 2004
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posted
For what it is worth - My LLMD just came back from the big conference in PA on lyme - I also gave him one of the posts here on how a number of people did well on amox - He also heard some of the same at the conference - I have just started with 3000mg a day right now. I was geood to here on this post that Amox is non-toxic- Some of the other ABX like mino, ceftin, I also did not do well on - too toxic for me. I am waiting to see how my monthly cycle responds to the amox - I am due in about two weeks for the standard die off cycle to occure for me. Then I might also question the 3000mg that I am on. This is a long road your on. I think there is plenty of time tosee how you respond. Just my thoughts.
Posts: 582 | From milwaukee wi | Registered: May 2005
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You have mentioned those unusually high oral amoxycillin doses a number of times. Have you found any information the actual serum levels of the med that can be achieved orally? I know for most oral meds the serum level does not increase linear to the amount ingested after a certain point.
In other words the serum level after taking 1 gram might be aproximately double of what you would get from taking 1/2 a gram, but taking 20 grams does not mean you necessarily get 20 times the serum level that 1 gram would give. Only so much can absorb.
This sort of thing would be true for alot of orally administered drugs, and the actual numbers would be all over the map, depending on which drug was involved.
My question: Have you seen any data on the serum levels of amoxycillin that can be achieved with very high oral doses? It would be good to know what the practical limits of oral dosing are. You would think there would at least be some animal studies somewhere as long as this drug has been around, but I have never seen anything that addressed really high oral doses of amoxycillin.
Anyone?
Posts: 714 | From San Antonio TX | Registered: Oct 2004
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Areneli
Frequent Contributor (1K+ posts)
Member # 6740
posted
I have seen a study showing that 6 g of Amoxy is inefective. My herxes after Amoxy were dose dependent: the more Amoxy, the stronger are herxes ; there was a difference between 18 and 24 g per day and difference between 24 and 27 g per day. In my opinion there is a point of going higher but if you hesitate, don't do it.
PS
I don't measure blood level of Amoxy - here in Canada they cannot do it.
Posts: 1538 | From Planet Earth | Registered: Jan 2005
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Michelle M
Frequent Contributor (1K+ posts)
Member # 7200
posted
My second month of treatment for neuroborreliosis was 3000 mg of Amoxy a day plus 1500 mg of Probenecid.
My LLMD says if infection is present, it will cross the blood-brain barrier.
I musta, because for about 17 days straight my head shrieked worse than at any time in my six months of treatment.
The Probenecid is known to keep the levels of Amoxy higher in your system.
It's good stuff. And unlike some other meds, it doesn't make you sick (at least for me) and is well tolerated in other respects.
Once my "brain herxes" settled down a bit, it got much better. I am still on it now, only we've added in Flagyl... (And that's another whole story...
Best of luck to you!
The "Other Michelle"!
Posts: 3193 | From Northern California | Registered: Apr 2005
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