posted
MGUS: (monoclonol gammopathy of undetermined significance) is something I've had since '99 after I was diagnosed with osteoporosis. It's a precursor to myeloma.
Now with Lyme, there was a change in the new test I just had (freelite) which takes the place of the 24-hr urine test (different than a 24-hr test for Lyme), and the freelite is much more sensitive and can spot free kappa/lambda light chains.
KLC was increased a little, however, ratio was fine, but, still....
Anyone have it? I'm curious if anyone else has seen a correlation in MGUS/myeloma or any other cancer.
I do wonder if some Lyme causes cancer cells to proliferate which a person may already have or if it initiates cancer cells in the first place.
Any information appreciated.
lifeline
Posts: 983 | From FL | Registered: Dec 2002
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posted
Hi lifeline....I have MGUS as well. It was diagnosed in 2005. I, too, have wondered if there is any correlation between MGUS and Lyme.
I have had Lyme for 28 years but was just recently diagnosed and undergoing treatment.
I wonder how many others may have MGUS and not be aware of it.
Donna
Posts: 13 | From SW Florida | Registered: Jun 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Brainstorming and hopefully give you more clues to help you to figure out what is going on:
I very quickly went to the first website that google brought up to describe MGUS and saw the words,
"multiple myeloma". I stopped reading.
I have a neighbor whose mom had this (she passed) and whose brother is now suffering. This is cancer of the bone marrow.
This looks to be triggered by the Th2 immune system pathway...and has been hinted at being viral triggered - EBV (mono) initially. There apparently is a genetic (recessive) tendency which can emerge.
This has to do with the Beta cells that originate in the bone marrow. Our white blood cells originate in either the thymus (T- cells) OR the bone marrow (B -cells).
It is STRONGLY linked to celiac disease as well... a gluten intolerance...and that is on the rise in the U.S. (bigtime). It OFTEN goes undetected.
Easy to check (but not fun)...go on a gluten free diet for a month and see if the symptoms start to go away. You have to be really good about it. No cheating. Digestive problems (diarrhea), tired, anemia are main symptoms.
More sophisticated testing can be done...not esp. fun.
The good news is...if it is celiac, this can be STOPPED before it goes into multiple myeloma, by simply following a restrictive diet.
I repeat...you can STOP this from going into cancer!!!
They are working right now on duplicating the 2 enzymes so those who suffer from this will be able to eat a normal diet once again...hopefully soon.
The cancer connections...well, Bb follows the glycolysis and cholesterol pathways as do breast and prostate cancer.
PFK...the rate limiting enzyme for glycolysis drops during "oxidative stress" and anemia happens. Melatonin goes in to "save" the RBCs, but copper is needed to release the iron stores. Oxidative stress, too many damaging free radicals, is very destructive to all the cells of our body. I would suspect that immature cells would be quite vulnerable.
While Bb looks to be upregulating the Th1 pathway (cells that originate in the thymus, not bone marrow), this may impact the efficiency of the Th2 pathway which usually handles several viruses, so they rear their ugly heads. (Chicken pox as a kid, shingles as an adult - reactivated virus, different presentation).
One pathway downregulates the other. They both never work "simultaneously". The body has to decide what is the biggest immediate threat and responds accordingly.
I hope you will consider giving the gluten free diet a try and see if this helps.
I think it is a strong possibility...you may have developed a gluten intolerance because for whatever reason, you are no longer making 1 or 2 of the specific enzymes needed to breakdown gluten.
Certainly developing a lactose intolerance is common today especially as we age.
Enzymes can be easily destroyed...too easily.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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david1097
Frequent Contributor (1K+ posts)
Member # 3662
posted
Have you been tested for bartonella? There as a number of reports of bartonelliosis having caused MGUS. Japaneese reports) The MGUS went away after LONG treatment for bart. I suppose that other infectious agents could cause the same thing too.
In a small population, MGUS does progress to mulitple myeloma. People with persistently increasing levels are sometimes monitored periodically via marrow biopsy.
Bascially you are at risk but the risk is low.
Posts: 1184 | From north america | Registered: Feb 2003
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There is also an herb called Graviola from Raintree that is suppose to be great at getting rid of cancer, or preventing it. Doesn't cost much either. Of course you probably already know that Artemisinin is an effective cancer fighter.
-------------------- You're only a failure when you stop trying. Posts: 945 | From U.S | Registered: Oct 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
In lyme, too much TNF alpha and IL 1 (Beta) are produced.
The beta cells (from bone marrow) control metalloproteinases...which is why this is up.
Too much of these is not good.
*The IgM antibodies from the beta cells production is dependent on the level of OTHER cytokines.*
Patients with celiac disease have immunoglobulin (Ig) M antibodies and IgA antigliadin antibody in gut secretions; this pattern of intestinal immunity may be a marker of latent celiac disease.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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