robi
Frequent Contributor (1K+ posts)
Member # 5547
posted
What do ya'll know about amylose and leptin.
My amylose is high (10 points over the high end of normal) and I am gianing weight. Dr. S. in Maryland talks about a no amylose diet.
Any info of this appreciated. I know thee is a book but wanting info on experiences before investing in the book.
Thanks, robi
-------------------- Now, since I put reality on the back burner, my days are jam-packed and fun-filled. ..........lily tomlin as 'trudy' Posts: 2503 | From here | Registered: Apr 2004
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robi
Frequent Contributor (1K+ posts)
Member # 5547
posted
Up to see if anyone knows
-------------------- Now, since I put reality on the back burner, my days are jam-packed and fun-filled. ..........lily tomlin as 'trudy' Posts: 2503 | From here | Registered: Apr 2004
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riversinger
Frequent Contributor (1K+ posts)
Member # 4851
posted
Robi, I started a low carb diet long before I knew about the no amylose diet. I lost 40 pounds over two years on low carb, which is essentially no amylose, but even more restricted,
When I finally had my Leptin tested, it was pretty low, at 11, but Dr. S told me it could go even lower. So far I haven't been able to get it down, but we think I am still having some toxin exposure.
A no amylose diet means no sugar, no fruit juice, but you can eat fruit, except bananas, no underground vegetables except onions and garlic, and no grains.
So it has fewer restrictions, as you can eat some carbs. I don't know how it would work, for sure, as I find some of the other carbs are hard on my blood sugar, so I still don't eat them much.
posted
The chiro I work for, Dr. P, is big on the leptin-insulin issue. Just as insulin receptors on the cells burn out, causing your insulin to eventually go up, leptin receptors on the hypothalamus burn out and eventually your leptin is found to be high.
Since sugar and fat can both be burned for energy, Dr. P is big on converting people to 'fat-burners,' as there is a very limited intracellular capacity for glucose storage, which causes sugar cravings when sugar-burning people get hungry. If they don't eat carbs, then their body breaks down protein (muscle!) into sugar (which is why bodybuilders often get up in the middle of the night to take sugar).
If you switch from a high-sugar to a high-fat diet you can train your body to burn fat. Thus, when you get hungry (which happens less, because fat is more satiating), you eat fat, and if you don't, your body breaks down fat, as opposed to muscle.
So not only does your insulin get normalized, but your leptin and weight does as well - provided you don't eat sugars, grains, or excess protein (which can convert to sugar). Carbs should come from non-starchy veggies (all above-ground) and fats should be healthy saturated and unsaturated from grass-fed meat, wild fish, coconut oil, nuts, etc.
The Rosedale Diet does a good job of exploring the leptin issue. I recommend it.
The conclusion: eat sugar to get fat, eat fat to get thin.
Posts: 45 | From Pittsburgh, PA | Registered: Nov 2005
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riversinger
Frequent Contributor (1K+ posts)
Member # 4851
posted
Big B,
I've found what you say to be true. I do best with a good dose of fat in my diet, including good quality saturated fats. Otehrwise I am hungry all the time. And the more fat I eat, the more weight I lose.
Yes, I suppose there is a limit, but fat fills you up, so I don't seem to have hit the limit so far. Maybe if I was worried about losing really fast, it would be a problem, but I have been happy with a nice, steady loss. Eating fat lets me feel full, but lose at the same time.
Obesity and Leptin (8/11/1999) The first report of a defective leptin gene in humans came from a team at Cambridge University last year.The hormone leptin can influence how much we feel like eating. A defective leptin gene will influence our eating patterns.
Leptin, the protein of the OB gene, is thought to influence weight regulation by acting in the central nervous system to decrease food intake. 5-HT dose-dependently increases leptin levels in mice.
Our results suggest that the patients with manic episodes and those with bipolar I disorder in full remission seem to be associated with
decreased serum cholesterol and leptin levels.
(Copyright � 2003 S. Karger AG, Basel)
Within the liver, leptin treatment reduced the activity of 3-hydroxy-3-methylglutaryl-CoA reductase, but it did not change activities of cholesterol 7 -hydroxylase or acyl-CoA:cholesterol acyltransferase. These data suggest that leptin regulates biliary lipid metabolism to promote efficient elimination of excess cholesterol stored in adipose tissue.
In other words, leptin...a hormone...reduces the activity of HMG CoA reductase. Mg and Benicar work by INactivating the enzyme HMG CoA reductase...they put the brakes on the cholesterol pathway...which IS the pathway that Bb takes.
Leptin, a recently discovered protein hormone produced by fat cells, decreases food intake and increases energy metabolism. In normal younger adults, an increase in body fat triggers an increase in leptin levels, and vice versa. In contrast, abnormally elevated leptin levels are strongly correlated with decreased body fat, and leptin deficiency in children has been reported to result in massive obesity. In elderly women, leptin levels decline with the decline in body fat that occurs after age 70.
In elderly men, however, leptin levels increase despite the decline in body fat. This increase is related to the decline in testosterone levels that occurs with age.
The importance of leptin in decreasing food intake with age is unknown. Postmenopausal women with high leptin levels tend to eat somewhat less than those with low leptin levels.
High blood insulin also leads to lower HDL (the good cholesterol). It does this by increasing the removal of a part of the HDL molecule to VLDL (bad cholesterol) and the higher the triglycerides (TG) the more this happens.
High insulin also plays an important role in stimulating the liver to make more cholesterol. Lepin is one of the "king pin" organizers of getting messages from your fat stores to your brain...to tell it how much energy is available and what should be done with it.
Leptin plays a HUGE role in the development or not of heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and in aging.
High, poorly controlled leptin levels are very pro-inflammatory and plays a key role in other pro-inflammatory biochemicals manufacture - which leads to inflammatory disease such as heart disease, arthritis and diabetes.
You know...leptin is so much more important to your heart health than cholesterol..yet very few practitioners know anything about it. In fact what they have found is that most overweight/obese people actually have HIGH circulating leptin. Which means that the overweight are not low in the hormone..but like Type 2 diabetics, their bodies' cells are insensitive to their leptin, causing more and more to be secreted..which of course worsens the problem, because, as mentioned before, more leptin means it takes more and more food before your brain says you have had enough and more sugar cravings and more storage of fat, not buring of fat.
The BIG deal here is that only fat cells makes leptin...so your body makes more fat cells to make more leptin and the vicious cycle is set up!!
Negative feedback from cholesterol. Insulin favors synthesis. Glucagon blocks synthesis. Specific drugs can block HMG CoA reductase, inhibiting cholesterol synthesis.
Choline is one of the B-complex vitamins and is a component of lecithin. Though choline can be manufactured internally from amino acids methionine and serine, it has recently been designated an essential nutrient.
It is necessary for the production of acetylcholine, an important neurotransmitter. Low levels of this neurotransmitter are associated with the memory loss of Alzheimer's disease and Huntington's disease. It is also essential for the metabolism of fats and the removal of fat from the liver.
In humans, choline deficiency can lead to liver impairment. Being an essential vitamin means that it is required by the body but not made in adequate amounts--so we need to get it in our diet.
Choline also aids hormone production and minimized excess fat in the liver as it aids fat and cholesterol metabolism. Without choline, brain function and memory are impaired.
It is also needed for the proper transmission of nerve impulses from the brain through the central nervous system as well as for gallbladder regulation and liver function. Choline is also instrumental in lecithin formation.
Lecithin is a naturally occurring substance found in every living cell of the body, especially the brain and the liver. It is a natural source of choline in the form of phosphatidylcholine.
It has numerous functions within the body, acting as a powerful fat emulsifier that protects the entire body from excess accumulation of fats.
Choline is involved in production of acetylcholine. Acetylcholine must be present in the body for proper function of the nervous system, including mood, behavior, orientation, personality traits, judgment; it is also involved in the removal of fats from the liver.
The benefits of choline are almost too many to list, but include:
� Protects against damage to cells by oxidation. � Protects against cardiovascular disease. � Protects against memory loss. � Prevents some diseases of the nervous system, such as Alzheimer's disease. � Treats Alzheimer's disease. � Treats liver damage caused by alcoholism. � Lowers cholesterol level in human serum.
Believe it or not...restore the balance to heal.
Acetylcholine's molecular formula is:
C7H16NO2
See H16?
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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robi
Frequent Contributor (1K+ posts)
Member # 5547
posted
Thanks to all of ya'll.......
Well, I guess its time to come clean. I eat really healthy and really clean ............ organic and low carb. In 1998 I was 283 lbs. By 2000 I was 150 lbs. Got healthy through low carb and exercise (a lot ... six days a week at the gym).
It was while I was running a Thanksgiving Day Race in 2003 that I got the tick bite that landed me here.
So I was obese, got healthy cause I wanted to and then got hit with this....oy vey!!
OK, back to the point ........... so I do low carb. The "real" Low carb..... meat, veggies, healthy fats. I don't do the net grams carb "lie". I don't think that works. I stay away from processed foods of all types. I guess I am already on a low amylose diet.
So why is my Leptin high? Last year it was 17 this past week I tested at 36.
At one point I decided to go gluten-free. In my mind that meant I could eat things like gluten-free rice bread and gluten free pasta and other carb foods that were gluten-free.
I guess this is where I messed up. I wanted to eat those foods and was able to rationalize that they were healthy because they were gluten-free.
Bottom line is they are FULL of carbs. So I guess thats why my leptin, blood sugar and weight are out of contol.
Back to the standard low carb for me ( actually I started a few days ago beacause of the # I saw on the scale..... 169 .......... don't tell anyone though.
All the replies really helped me out. thanks much.....
where would we all be with out each other?, robi
-------------------- Now, since I put reality on the back burner, my days are jam-packed and fun-filled. ..........lily tomlin as 'trudy' Posts: 2503 | From here | Registered: Apr 2004
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riversinger
Frequent Contributor (1K+ posts)
Member # 4851
posted
Robi, if your leptin is that high while eating low carb, you may have leptin resistence, which is what Dr. S sees when there are neurotoxins.
The toxins are implicated in fat metabolism, and stimulate leptin production, but the leptin doesn't end up working the way it should. One of the things that doesn't happen is that it doesn't stimulate melanocyte stimulating hormone, or MSH. Low MSH will promote more leptin production.
It also will produce pain, sleep problems, gut issues, immune problems, and a whole slew of other issues. You may want to look further into whether you have one of the neurotoxin susceptible gene types.
Actos is used to lower the leptin, and the CSM is used to keep the neurotoxins low. Just something for you to consider. Let us know how it works out for you.
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