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» LymeNet Flash » Questions and Discussion » Medical Questions » Fluconazole-resistant Candida ; CINNAMON

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Author Topic: Fluconazole-resistant Candida ; CINNAMON
caat
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Below is just one study I'm finding on cinnimon (Cinnamomum spp) as an antifungal. I found other studies that are very interesting and will post them when I feel better. better yet search pubmed for yourself with "Cinnamomum antifungal".

This is probably the sloppiest abstract, but half of it is in vivo. Cinnimon is useful against many other fungi as well- aspergillis (sp?) etc. and is being tested as an antifungal in the nursery (plant) feild. Tested out as most effective along with clove on many fungi, compared to other common essentials.


Cinnamomum cassia should be very nearly as effective as the species they use here in vitro. It is common cinnimon as sold in the US. Might as well say AS EFFECTIVE... Forget the future "spin" and save money... Bulk is about $12 a lb or less for fresh ground stuff at an herb store that carries bulk. C. zeylanicum is probley much more expensive especially if it becomes marketed with a spin. Both have the active chemicals. Doctors in the US before antibiotics used C. cassia. Bulk herbs are generally much fresher than in jars or capsuls.

traditional western herbal use is one small teaspoon 3x a day or so. But- that's old school and doesn't address fungal infections. Was used for uterine hemerages at a slightly larger dose. Haven't found anything on optimal dose for bad systemic yeast.

CAUTION; in larger doses excites then depresses the nervous system- can be fatal in large dose. Has bad side effects at half the fatal dose. Looks like a nuerotoxin. ALSO it has an effect on the circulatory system- stops uterine hemerages. Might be a bad idea while on IV... ALSO cinnimon in medicinal doses is an irritant- can inflame GI system. Heart ?? it is a stimulant... haven't found any effects on the heart yet but am very suspicious.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8874667&query_hl=10&itool=pubmed_docsum

Am J Chin Med. 1996;24(2):103-9. Related Articles, Links


In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis.

Quale JM, Landman D, Zaman MM, Burney S, Sathe SS.

Department of Medicine, Department of Veterans Affairs Medical Center at Brooklyn, New York USA.

Fluconazole-resistant Candida species are an emerging problem. In this report, the in vitro activity of C. zeylanicum against fluconazole-resistant and-susceptible Candida isolates is described. The MICs of the bark of C. zeylanicum ranged from < 0.05-30 mg/ml, and were slightly better than commercially available cinnamon powder. Trans-cinnamaldehyde and O-methoxycinnamaldehyde had MICs of 0.03-0.5 mg/ml. The MICs of selected cinnamon candies and gums generally ranged from 25-100 mg/ml. Five patients with HIV infection and oral candidiasis received a commercially available cinnamon preparation for one week. There of the five patients had improvement of their oral candidiasis. Clinical trials will be necessary to determine the usefulness of cinnamon for the treatment of mucosal candidiasis.

Publication Types:
Clinical Trial

PMID: 8874667 [PubMed - indexed for MEDLINE]

[ 26. February 2006, 03:23 AM: Message edited by: caat ]

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pq
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since this helps/stops uterine hemorrhages, i wonder if this would promote, or worsen the kind of coagulation due to infection, and/or other kinds of coagulation; or help promote clotting associated with injuries, but not promote coagulation due to infection.

some meds. limit blood loss by causing the arteries to contract, but without inducing blood clotting.

sorry for my question not being well-formulated, as i'm not versed the various kinds of mechanisms assoc. with different kinds of coagulation issues/causes, as many members here are.


jelly belly? marnie? anyone ? where art thee? [Big Grin]

thanx

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bettyg
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quote:
Originally posted by caat:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&
list_uids=8874667&query_hl=10&itool=
pubmed_docsum

Hi pq,
Could you edit/pencil icon your post on the LONG web site making it 4 lines vs. 3?

It caused your post to go super wide and we neuro lymies can't toggle back & forth per line & comprehend what sentence is saying....thanks a million pq. Please double check it afterwards making sure it's back to normal width.

I'm on this med & would appreciate reading your post about it. Have a WARM weekend pq. It was -15 actual temp plus windchill below this am in Iowa...burr!

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5dana8
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Hi Caat
Thanks for posting this article on cinnamon! [Smile]
It's good to know the toxic levels.

I have been putting a tsp of cinnamon in my oatmeal for breakfast and so far hasn't upset my sensitive stomach.

But I don't think I will try cinnamon at all without a meal

From the maker's diet there is a large section on cinnammon:

"It also says it "contains benzldehyde,an antitumor agent"... and "kills many bacteria-causing tooth decay and disease-causing fungi & viruses." ...

And " may prevent UTI"s" Although a powerful gernmicide...

The warnings are: DONOT ingest cinnamom oil. It may cause vomiting or kidney damage."

I am going to get some cinnamon oil and try it on the bottoms of my feet. I have heard this is also a good way of absorbing oil based herbs.

Take care

--------------------
5dana8

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caat
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one of those studies found that the MIC's (effective doses for killing organisms) was lower for various fungi than for bacteria. Not surprized- it's been used as an antifungal by orchid growers for quite a while. So... seems it's more effective on yeast and molds than on bacteria. The old doctor's pharmacopias suggested to use other things for intestinal upsets (bacterial?) as cinnamon was too much of an irritant at effective doses for intestinal upsets. This was before antibiotics- when doctors used herbs and minerals. Of course- some intestinal upsets involve raw sore intestines too- so, FWIW...

PQ- I don't know. I did read the entries in several herbal compodiums and it was theorized that it stopped uterine hemhorages (d*mb, I can't spell!) because of inducing spasms. BUT... It could do both I suppose. Don't know.


5dana8,

Yes, don't ingest cinnamon oil unless under the direction of an herbalist! It's very concentrated and will kill you in the wrong dose. The fatal dose for a medium sized dog in the 1800's was 5 draughts of oil. At 2.5 draughts another dog sustained obvious damage. I have no idea what a draught is. An herbalist suggested the oil to me but warned I should be very careful & do the research.

I don't think a tsp of cinnamon powder is a big deal though. LOL, if it was there would be a lot of dead people from it... I had 3 tsp in scrambled eggs just now, I don't think it will be a problem.

If anyone else has the energy to research doses of powder or oil etc, by all means!! I'm too tired to be persistant right now. My liver is recovering from bart tx.

BTW, the stuff repels spiders too. I put about 8 ounces each in the storage compartments under my bed and couch last year to repel mold and have had NO spiders crawling up from underneath to bite me for the entire year [Smile] Someone should throw a tick in a jar of it and see if it dies... die tick die!

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5dana8
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Thanks caat for the added information on cinnomin. [Smile]

I don't think I could stomach cinnomin on eggs! LOL. But hats off to you.

I wonder if it is like the use of garlic - inthat you have to space ot 1-2 tsp thre out the day?

Someone needs to do more research on this. I think cinnomin has promise but not sure anyone has come up the trials at the proper dosage and
timing. [Smile]

Take care
p.s.: When I eat cinnomin I feel warmer for a short period of time. I wonder why?

--------------------
5dana8

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Porsche
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It also helps with diabetes!

"Just half a teaspoon of cinnamon a day significantly reduces blood sugar levels in diabetics, a new study has found.

The effect, which can be produced even by soaking a cinnamon stick your tea, could also benefit millions of non-diabetics who have blood sugar problem but are unaware of it.

The discovery was initially made by accident, by Richard Anderson at the US Department of Agriculture's Human Nutrition Research Center in Beltsville, Maryland.

"We were looking at the effects of common foods on blood sugar," he told New Scientist. One was the American favourite, apple pie, which is usually spiced with cinnamon. "We expected it to be bad. But it helped," he says.

Sugars and starches in food are broken down into glucose, which then circulates in the blood. The hormone insulin makes cells take in the glucose, to be used for energy or made into fat.

But people with Type 1 diabetes do not produce enough insulin. Those with Type 2 diabetes produce it, but have lost sensitivity to it.

Even apparently healthy people, especially if they are overweight, sedentary or over 25, lose sensitivity to insulin. Having too much glucose in the blood can cause serious long-term damage to eyes, kidneys, nerves and other organs.

Molecular mimic
The active ingredient in cinnamon turned out to be a water-soluble polyphenol compound called MHCP. In test tube experiments, MHCP mimics insulin, activates its receptor, and works synergistically with insulin in cells.

To see if it would work in people, Alam Khan, who was a postdoctoral fellow in Anderson's lab, organised a study in Pakistan. Volunteers with Type 2 diabetes were given one, three or six grams of cinnamon powder a day, in capsules after meals.

All responded within weeks, with blood sugar levels that were on average 20 per cent lower than a control group. Some even achieved normal blood sugar levels. Tellingly, blood sugar started creeping up again after the diabetics stopped taking cinnamon.

The cinnamon has additional benefits. In the volunteers, it lowered blood levels of fats and "bad" cholesterol, which are also partly controlled by insulin. And in test tube experiments it neutralised free radicals, damaging chemicals which are elevated in diabetics

http://www.newscientist.com/article.ns?id=dn4413

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5dana8
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Hi porsche
[Smile]
Thanks for the link. very interesting,.
I wonder is your blood sugar is too low if this may not be the thing to take?
So many questions...
sorry

--------------------
5dana8

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Linda LD
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Interesting.

One time my youngest was around two and ate apple sauce with cinnamon. It was all he had and he broke out in a HORRIBLE rash. Duck told me to never give him cinnimon again. I went to day care a few years later--she had forgotten and was bragging about how much cinnimon on French toast my little one had eaten.

Now I wonder if the rash was the cinnimon killing yeast or bacteria or something--maybe it was a herx???

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pq
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Betty,

i'm not sure i understand what you mean. what long post? my post on this thread, or another post?

thanks

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caat
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well... 3 teaspoons 2ce yesterday didn't do anything- my underarms still smell like yeast today.

I had an 1/8th cup in hot cocoa- 2ce tonight. Tummy feels warm but it's a pleasant warm. We'll see.

Not good to mix with liquid before hand. It turns into a mucous-y consistancy after a while. But, hey, maybe that's better for your stomack... Still tastes good.

5dana8, The old compodiums recommend 3 or 4 times a day- not every hour or two. That part would still hold I'd think.

& it's pretty good in scrambled eggs [Smile]

>>I wonder is your blood sugar is too low if this may not be the thing to take?

I'm not porsch, but the answer would be yes according to the report posted. Just a little bit should do it according to that.

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caat
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Old western medicine.

NOTE- please DO NOT take ANY maximum doseages of anything from any of these old medicaL manuals... and don't take any strong herbs or strong herbal doses unless you know what you are doing and are clear about what you are doing.

IMPORTANT; "Specific Medicine Cinnamomum" is NOT pure cinnamon oil. Do not use this dosage for cinnamon oil !!

The old materia medicas are the stuff hardly anyone practices anymore. Some things in the old Materia Medicas (herbal doctors' manuals or compodiums) are deadly. They commonly used things like belladona, ergot and arsenic. Cinnamomum is a safer herb, but not all herbs are safe.

from Micheal Moore's site (the herbalist not the film director);
http://www.swsbm.com/homepage/

Lots of other materia medicas on that web site.

Felter’s Materia Medica 1922 http://www.swsbm.com/FelterMM/Felters-C.pdf


CINNAMOMUM.
I. Cinnamomum Saigonicum. Dried bark of an undetermined species of Cinnamomum.
Chiefly from China.

II. Cinnamomum Zeylanicum. Dried bark of cultivated Cinnamomum zeylanicum,
Breyne. (Nat. Ord. Lauraceae.) Ceylon.
Common Names: Cinnamon; (1) Saigon Cinnamon; (2) Ceylon Cinnamon.

Principal Constituents.—A volatile oil (Oleum Cinnamomi), tannin, and sugars.
(Oil of Cinnamon of medicine is Cassia Oil (Oleum Cassiae) derived from
Cinnamomum Cassia (Nees), Blume.)

Preparations;

1. Specific Medicine Cinnamomum. Dose, 5 to 60 drops. [!! THIS IS NOT CINNAMON OIL !!]

2. Oleum Cassiae, Oil of Cinnamon (Cassia Oil), a yellowish or brownish
fluid becoming darker and denser by age and exposure, and having the odor and
taste of cinnamon. Dose, 1 to 5 drops.

Specific Indications.-Passive hemorrhages.
Action and Therapy.—Cinnamon is an aromatic stimulant,
carminative and astringent. Besides it possesses marked internal
hemostatic power. That this is not wholly due to the tannin contained
in the bark is shown by the prompt action of the tincture of the oil. Oil
of Cinnamon has properties which make it nearly specific for certain
conditions.

While no tests have been made that convinces one of its
power over germ-life, there seems to be no question that some such
germicidal action is exerted by it in acute infections, as “common
colds,” and as la grippe or epidemic influenza. Aromatic bodies, like
cinnamon and camphor, have been overlooked in recent years, though
the use of the latter has been revived as an antiseptic stimulant in
pneumonia.

That they possess antibacterial virtues we believe will be
found true should investigations be made of them in that line.


[...]

Cinnamon has been proved in Eclectic practice to be a very important
remedy in hemorrhages. It acts best in the passive forms.

The type of
hemorrhage most benefited is the post-partum variety, though here it
has its limitations. If the uterus is empty and the hemorrhage is due to
flaccidity of that organ due to lack of contraction, then it becomes an
important agent. Then it strongly aids the action of ergot and should be
alternated with it.

[...]

Cinnamon should be frequently given,
preferably a tincture of the oil, though an infusion might be useful, but
it cannot be prepared quickly enough or be made of the desired
strength.

[...]

Other hemorrhages of a passive type are benefited by cinnamon.

[...]

Hemorrhages from the stomach, bowels, and renal organs
are often promptly checked by the timely administration of cinnamon.

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caat
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5 days later. It's working... wow. yep, it's working. Yeast is going down.

I'm taking 1/8th cup or so 2ce a night. Probley too much.

Now for the *real* test- I'm going to eat some sugar- Polynesian pineapple chicken, either tonight ot tomorrow night depending if I feel like cooking it later tonight...

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Porsche
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Caat,

So what happened with the Polynesian pineapple chicken? Did you survive, and how about an update on the cinnamon therapy? Do you know if it interferes with any abx?

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blackbirdsings
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This is really interesting. I think my acupunture person said something about cinnamon having a warming effect.

I LOVE the stuff and always have. Since I have gotten sicker, I use more cinnamon. I carry at least one bottle around with me. I put it on cappacianos in copius amounts.

Also, good on toast, apple sauce, yogurt, ice cream, many desserts, and it actually goes well with some meats, rice, soup, etc.

I know it's a bit odd to carry your own cinnamon bottle around and keep one in the car, but it really must do something considering how much I use and crave it.

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5dana8
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Hey blackbirdsings

Re: your current problems with nausea.

Please be careful with the cinnamon
I recently had to stop because it was contributing to my nausea.
[puke]
Take care

--------------------
5dana8

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