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» LymeNet Flash » Questions and Discussion » Medical Questions » has anybody heard or tried sustained-release doxycycline

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Author Topic: has anybody heard or tried sustained-release doxycycline
blueskyfaith
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Member # 8723

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a subcutaneous injection of sustained-release doxycycline (Atridox; Atrix Laboratories, Fort Collins, Colo.) described in the paper:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15215128&query_hl=8&itool=pubmed_docsum

Plasma doxycycline levels in mice over a 21-day period after a single oral dose of doxycycline hyclate or a single subcutaneous administration of sustained-release doxycycline hyclate (Atridox)
Posts: 77 | From USA | Registered: Feb 2006  |  IP: Logged | Report this post to a Moderator
welcome
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Never heard of it till this. Seems likea good thing for people going into wild/semi-wild areas for short excursions ie, hunters/researchers/loggers etc..

As a side note here's an intersting clip from the abstract:
"Interestingly, concentrations of doxycycline in plasma after the administration of sustained-release doxycycline hyclate (0.1 to 0.5 μg/ml) were lower than those reported as the MIC in vitro for B. burgdorferi (1.6 μg/ml) (5). Whether this reflects a lack of correlation between in vitro and in vivo effects of doxycycline, the length of exposure to the drug, or the strain of B. burgdorferi used (B31 versus 297) remains to be tested."

Hmmm.
Posts: 294 | From nevada | Registered: Sep 2005  |  IP: Logged | Report this post to a Moderator
   

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