Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions.
Pound MW, May DB.
Department of Pharmacy Practice, Campbell University School of Pharmacy, Buies Creek, NC 27506, USA. [email protected]
OBJECTIVE: To review the aetiologies and preventative methods associated with Jarisch-Herxheimer reactions (JHR).
DATA SOURCES: Ovid Medline (1966-June Week 1 2004) was utilized to assess biomedical literature; a review of the bibliographies of articles was also performed.
DATA SYNTHESIS: JHR often occurs with the treatment of spirochete infections.
However, the mechanism by which the reaction takes place is not clearly defined.
CONCLUSION: Studies suggest with conflicting evidence that the JHR is caused by release of endotoxin-like material from the spirochete as well as cytokine elevation in the body.
It appears the type of drug and the rate of spirochete clearance from the body have little effect on the incidence of the reaction.
Many pretreatment options have been explored with limited efficacy with the exception of anti-tumour necrosis factor antibodies.
Publication Types:
* Review
[ 19. March 2006, 02:27 PM: Message edited by: blueskyfaith ]
Posts: 77 | From USA | Registered: Feb 2006
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posted
Please see this article for detail. Anti-tumor necrosis factor antibodies have been extensively studied on arthritis and clinical drugs may have become available by some big pharmaceutical companies or in clinical trials.
Basically it's anti-inflammation. Somebody (GiGi?) menthioned here using anti-inflammation herb got good results.
Suggesting that lyme pains may partially be from inflammation.
posted
Pol Merkuriusz Lek. 1998 Mar;4(21):126-9. Related Articles, Links
[Concentrations of tumor necrosis factor alpha and interleukin-1 beta in cerebrospinal fluid in the course of tick-borne encephalitis]
[Article in Polish]
Kondrusik M, Hermanowska-Szpakowicz T, Jaroszewicz E.
Kliniki Chorob Pasozytniczych i Neuroinfekcji Akademii Medycznej w Bialymstoku.
CSF concentrations of TNF-alpha and Il-1 beta were detected in patients with TBE.
The cytokines were detected by immunometric assay by MEDGENIX kit.
CSF Concentrations of TNF-alpha and IL-1 beta in patients with TBE were significantly higher than in control group before as well as after treatment and normalization of CSF parameters.
These concentrations were lower comparing to one obtained in group of bacterial meningitis. There was no correlation between concentration of cytokines and other CSF parameters (cytosis, protein, glucose concentration).
Concentrations of analysed cytokines did not change significantly before and after treatment.
Detection of CSF concentrations of TNF-alpha and Il-1 beta in patients with tick-borne encephalitis can be used to evaluate efficacy of treatment and retreat of infection
Posts: 77 | From USA | Registered: Feb 2006
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posted
Interesting that someone in the U.S. is actually doing research on JH reaction. More, we want more!
The second article, by Polish authors, suggests spinal taps are good for monitoring cytokines. Hmmmm....can't they find a less invasive way to monitor?
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JimBoB
Unregistered
posted
Interesting thread to say the least. However, it appears they have NOT done any of this testing with herbs.
WITH the herbs, on a good protocol, such as I am on, there are VERY FEW, if ANY herxes. Keeping the blood cleansed with Sarsaparilla and other excellent herbs to work on the lymph system such as Red Root, make a HUGE difference, in how many and how strong the herxes are.
This is in the real world. I am not into the "medical" terms, and don't need to be, to get the job done. Just take what is already proven to do what it is supposed to do, without all the side effects.
[Effect of antibiotic therapy on levels of proinflammatory cytokines: interleukin IL-1, IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme borreliosis]
[Article in Polish]
Kondrusik M, Swierzbinska R, Zajkowska JM, Pancewicz SA, Grygorczuk S, Hermanowska-Szpakowicz T.
Kliniki Chorob Zakaznych i Neuroinfekcji Akademii Medycznej w Bialymstoku.
We estimated serum concentrations of cytokines: IL-1, IL-6, TNF-alpha in patients with diagnosed Lyme disease treated for 14 days with antibiotics. The detection of proinflammatory cytokines was performed by ELISA tests.
The examination was carried out before and after the treatment. The comparison with control group stated statistically significant higher concentration of IL-1, IL-6 and TNF-alpha before and after the treatment.
Comparing the concentrations of cytokines after treatment with control group showed normalization only in a few cases.
In the majority of cases serum cytokines concentrations remained significantly higher.
That is why we conclude that 14-day-therapy with antibiotic in patients with Lyme disease may not be sufficient.
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1: Neurol Neurochir Pol. 2004 Jul-Aug;38(4):265-70. Related Articles, Links Click here to read [Evaluation of proinflammatory cytokine (TNF-alpha, IL-1beta, IL-6, IFN-gamma) concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis]
[Article in Polish]
Kondrusik M, Swierzbinska R, Pancewicz S, Zajkowska J, Grygorczuk S, Hermanowska-Szpakowicz T.
Klinika Chorob Zakaznych i Neuroinfekcji, Akademia Medyczna w Bialymstoku. [email protected]
BACKGROUND AND PURPOSE: Neuroborreliosis is a tick transmitted disease which becomes an increasingly frequent diagnostic and therapeutic problem in physician practice.
The purpose of this work was to evaluate the concentration of proinflammatory cytokines: IL-1beta, IL-6, TNF-alpha, IFN-gamma in serum and cerebrospinal fluid of patients with neuroborreliosis.
MATERIAL AND METHODS: 20 persons with diagnosed neuroborreliosis and 10 persons as a control group were examined in this study.
The examination of serum and cerebrospinal fluid was performed twice, before and after 4-week therapy with antibiotics.
The concentration of cytokines was measured by the ELISA method using kits of Bender Medical System and Quantikine RD Systems.
RESULTS: The concentration of measured cytokines IL-1beta, IL-6, TNF-alpha and IFN-gamma in serum and cerebrospinal fluid was significantly higher before therapy.
After 4-week therapy with antibiotics the concentration of cytokines in cerebrospinal fluid decreased but was still higher than in the control group except for IL-1beta.
CONCLUSIONS: The detection of proinflammatory cytokine concentration in serum and cerebrospinal fluid might be helpful as another parameter monitoring the inflammation course and therapy efficacy.
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posted
Good grief, the things you tell us, Shelley. I never heard of a lyme doc doing a cytokine assay. Or if I heard it, it didn't register.
After years of reading about lyme stuff, I thought maybe there wasn't a whole lot more to learn. Ha.
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