LymeNet Flash: Abstract implies Doxy over Penicilin

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Abstract implies Doxy over Penicilin

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Topic: Abstract implies Doxy over Penicilin

blueskyfaith
Member
Member # 8723

posted

Infect Immun. 2006 Apr;74(4):2468-72.

Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin.

Montgomery RR, Schreck K, Wang X, Malawista SE.

Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street/TAC S413, New Haven, CT 06520-8031. [email protected].

Borrelia burgdorferi, the spirochetal agent of Lyme disease, is susceptible to killing by a variety of polymorphonuclear leukocyte (PMN) components.

Some are most effective against metabolically active B. burgdorferi. The abundant PMN cytoplasmic protein calprotectin, elevated 10- to 100-fold in inflammation, inhibits the growth of spirochetes through chelation of the essential cation, Zn.

Since the action of some therapeutic antibiotics depends on bacterial division, we investigated the antibiotic sensitivities of spirochetes in calprotectin.

In physiologic calprotectin, B. burgdorferi is not eliminated by therapeutic doses of penicillin G; in contrast, doxycycline is effective.

Calprotectin may modify the clearance of spirochetes at sites of inflammation.

Posts: 77 | From USA | Registered: Feb 2006 | IP: Logged |

pq
Frequent Contributor (1K+ posts)
Member # 6886

posted

yesterday i was just reading about calprotectin, zinc, and borrelia on medline, with the search expression, 'transition elements + borrelia'. there was one old article on zinc and calprotectin, and the article in the above post.

given yale's sordid past,current stance on several aspects of borreliosis, i'm viewing the apparent surety of this conclusion about the penicillin with a jaundiced eye, until trustworthy replication of the study is done.

For yale's role in borreliosis, see
http://www.actionlyme.org

[ 30. March 2006, 05:34 PM: Message edited by: pq ]

Posts: 2708 | Registered: Feb 2005 | IP: Logged |

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